Product Name: Zolpidem L-( )-hemitartrate
Chemical Family: Imidazopyridine derivative
Molecular Formula: C19H21N3O + 0.5C4H6O6
Synonyms: Zolpidem Tartrate, Ambien (pharmaceutical product name)
Manufacturer: Pharmaceutical laboratories or contract manufacturers responsible for synthesis
CAS Number: 99294-93-6
Recommended Use: Intended for research, pharmaceutical preparation, or sleep disorder medications
Contact Information: Provided on the packaging; poison control centers and medical emergency numbers accessible
Emergency Telephone Number: Found on MSDS provided with shipment or package insert
Hazard Classification: Acute toxicity (oral), Eye irritation, Acute inhalation toxicity
Pictogram: Exclamation mark
Signal word: Warning
Hazard Statements: Harmful if swallowed, May cause drowsiness or dizziness, Causes serious eye irritation
Precautionary Statements: Avoid breathing dust, Do not eat, drink, or smoke during use, Wash hands thoroughly after handling, Use in well-ventilated area
Routes of Exposure: Inhalation, ingestion, skin, eyes
Potential Health Effects: Sedation, headache, dizziness, nausea, CNS depression, respiratory difficulties in cases of overdose
Environmental Hazards: Toxic to aquatic life with long lasting effects
Component: Zolpidem L-( )-hemitartrate
CAS Number: 99294-93-6
Concentration: 97 - 100% (Active pharmaceutical ingredient)
Impurities: Trace levels, typically outlined by batch analysis
Other Ingredients: None for pure API; pharmaceutical products may include excipients
Inhalation: Move victim to fresh air, provide oxygen if classed as severe, seek immediate medical attention
Ingestion: Do not induce vomiting unless directed by medical personnel, rinse mouth, monitor for CNS effects, call poison center immediately
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical advice if irritation persists
Eye Contact: Rinse with plenty of water for at least 15 minutes, remove contact lenses if present, seek medical advice
Acute Symptoms: Drowsiness, loss of coordination, respiratory depression
Indication of Immediate Medical Attention: Overdose suspected, difficulty breathing, persistent unconsciousness
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Strong jets of water, which may spread burning powder
Specific Hazards Arising from Chemical: Emits toxic fumes under fire conditions, including carbon monoxide, nitrogen oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Special Procedures: Evacuate area, use water spray to cool containers, avoid inhalation of combustion byproducts
Thermal Decomposition Products: Oxides of carbon, oxides of nitrogen, tartrates
Personal Precautions: Wear gloves, lab coat, safety goggles, mask suitable for fine organic dust
Environmental Precautions: Prevent entry into watercourses, drains, or soil
Methods for Clean-up: Sweep up without generating dust, place in appropriate sealed container for disposal, ventilate area
Decontamination: Wash affected surface with soap and water after removal
Reporting: Large spills or releases should be reported in accordance with local regulations for pharmaceutical compounds
Handling: Wear appropriate PPE, avoid dust generation, use fume hood or appropriate containment, avoid contact with skin and eyes
Measures to Avoid: Eating, drinking, or smoking in handling area, inhaling powder
Storage Conditions: Keep in tightly sealed container, store in cool, dry, well-ventilated place
Storage Temperature: Store below 25°C unless otherwise specified
Incompatibilities: Strong oxidizing agents, acids, alkalis
Specific End Uses: Research, formulation, or as prescribed for medical use
Engineering Controls: Laboratory fume hood, ventilated enclosure, local exhaust ventilation
Control Parameters: No occupational exposure limit established, follow standard precautionary practices
Respiratory Protection: NIOSH-approved dust mask when handling bulk powder
Hand Protection: Chemical-resistant gloves (nitrile preferred)
Eye Protection: Safety goggles or face shield
Skin Protection: Laboratory coat, closed-toe shoes
Hygiene Measures: Wash hands after handling, avoid contact with face
Appearance: White or almost white crystalline powder
Odor: Odorless
pH (1% solution): Data not available; typically neutral
Melting Point: 167–173°C
Solubility: Freely soluble in water, sparingly soluble in ethanol
Boiling Point: Decomposes before boiling
Vapor Pressure: Not applicable
Relative Density: Data not available
Partition Coefficient (log Pow): 2.6 (Zolpidem base)
Other Data: Stable under normal conditions, not volatile
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: None under normal processing
Conditions to Avoid: Excessive heat, exposure to light, moisture
Incompatible Materials: Strong oxidizers, acids, alkalis
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, tartrates
Acute Toxicity: LD50 (oral, rat): ~500 mg/kg (as zolpidem base)
Routes of Exposure: Oral, inhalation, skin, eye
Effects of Short-term Exposure: Drowsiness, CNS depression, dizziness, headache, vertigo
Effects of Long-term Exposure: Potential for tolerance, dependence, impaired coordination
Symptoms of Overexposure: Confusion, respiratory depression, reduced consciousness
Carcinogenicity: Not classified as carcinogenic by OSHA, NTP, IARC
Reproductive/Developmental Toxicity: Possible risk in pregnancy, not for use in lactation
Sensitization: Not reported as a sensitizer
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Limited biodegradability in soil and water
Bioaccumulative Potential: Low, not expected to bioaccumulate significantly
Mobility in Soil: Moderately mobile in soil; potential for groundwater contamination is low
Other Adverse Effects: Avoid release to the environment, pharmaceuticals present risk to aquatic organisms even at low concentrations
Waste Treatment Methods: Incineration or landfill in accordance with local, regional, national, and international regulations
Product Disposal: Avoid discharge to drains or environment, unused substance should be handled as hazardous waste
Packaging Disposal: Rinse containers, dispose through licensed hazardous waste contractor
Precautions: Handle in compliance with environmental protection standards, ensure destruction eliminates pharmacological activity
UN Number: Not regulated as a dangerous good for transport by ground, air, or sea
Proper Shipping Name: Pharmaceutical product, non-hazardous for transport
Transport Hazards Class: Not assigned
Packing Group: Not assigned
Special Precautions: Avoid moisture, temperature extremes throughout shipping process
Environmental Hazards: Not expected during transport, but avoid accidental release
OSHA Status: Not classified under US workplace safety regulations
TSCA Status: Not listed for routine chemical substances
SARA Title III: Not subject to reporting
EU Regulation (EC) 1907/2006 REACH: Exempt as medicinal product, not subject to registration
WHMIS (Canada): Not controlled
Other National Regulations: Usually controlled substance (Schedule IV US, prescription required)
Labeling Requirements: Handle according to Good Laboratory Practice, pharmaceutical waste disposal regulations
Restriction on Use: Supplied for research, compounding, or prescribed medical use only
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