Zolpidem L-( )-hemitartrate sits on the list of important pharmaceutical materials for modern medicine. With its roots in the class of imidazopyridines, this compound serves in treatments needing controlled sedation and sleep modulation. Pharmacies and labs count on this material for the reliable quality it brings to finished drug forms, especially in regulated environments where medication quality and stability are closely watched. Knowing the full profile of this chemical—including its structural qualities, material properties, and handling considerations—brings clarity to its role in both drug development and daily clinical use.
At a fundamental level, Zolpidem L-( )-hemitartrate carries the same aromatic imidazopyridine core as its parent, Zolpidem, but it adopts a salt form through hemihydrate tartrate linkage. This molecular adjustment comes out in the chemical formula, which combines C19H21N3O and tartaric acid moieties. The molecular formula looks like C19H21N3O•C4H6O6•1/2H2O, showing both the active pharmaceutical ingredient and the stabilizing influence of the hemihydrate tartrate. A standard molecular weight for this compound falls above 440 g/mol, reflecting the added mass of the tartrate and water content. This complex brings a little more process stability than the base Zolpidem, balancing solubility and bioavailability in finished products. The tartrate salt's inclusion stands out for improving shelf-life and providing easier measurement during production.
Looking at it, Zolpidem L-( )-hemitartrate often appears as a white or near-white crystalline solid. Some samples can show up as fine powders or soft flakes, depending on processing. The density of this material runs in the range of 1.2 to 1.3 g/cm³, making it manageable for most pharmaceutical filling and blending processes—never too heavy for mixing, nor so light that it scatters or dusts easily. It gets packed in moisture-resistant containers since atmospheric humidity can shift its hydration state, impacting both bulk density and handling. This solid never forms clumped pearls, oily liquids, or amorphous masses; it holds a clean, defined crystal structure right from synthesis to final retail packaging.
Zolpidem L-( )-hemitartrate’s solid crystalline structure helps with physical stability, making the product easier to weigh, mix, and process under standard good manufacturing practice (GMP) guidelines. It dissolves in water more easily than base Zolpidem, thanks to the tartrate group’s ionic nature. Pharmaceutical scientists appreciate this property for making content uniformity and dosing more predictable. Chemical stability stands strong under normal indoor storage because the solid resists rapid degradation. Despite this, the compound still wants protection from direct sunlight, strong oxidizers, and acids, which could break down key molecular bonds. The material is neither overly volatile nor explosive, keeping risks of inhalation or sudden reaction low during handling, blending, or packaging. Whether working with raw materials or finished product, using tightly sealed jars and gloves adds an extra layer of reliability to both safety and shelf-life.
Buyers and quality controllers point to key markers when verifying a lot of Zolpidem L-( )-hemitartrate. Specification sheets list the HS Code at 2933399090, categorizing it clearly under heterocyclic compounds with nitrogen. Lab testing checks for a purity of at least 98.5%, with reference samples stored in certified temperature-monitored environments. The test for solubility, appearance, and melting point (expected in the 180–190°C range) all help spot counterfeits or off-spec materials. Powder X-ray diffraction or IR spectroscopy further confirm crystal form and prevent the risk of substitutions and fakes. The best suppliers stick to these documentation and verification routines every shipment, removing uncertainty for every downstream handler and user.
Zolpidem L-( )-hemitartrate sits in the same risk category as most controlled raw materials, and carries enough chemical activity to demand careful, respectful handling. Despite its ease of use in manufacturing, it can irritate eyes, skin, and especially airways if inhaled as dust. Workers need gloves, eye protection, and working fume hoods, not because the compound is particularly aggressive, but since routine care prevents both exposure and environmental release. Spill cleanup focuses on careful vacuuming—not sweeping—to prevent spreading powder into the air or onto surfaces. Prolonged direct contact or ingestion can bring health risks ranging from mild nausea to more serious neurologic side effects. Safe storage sticks to cool, dry spaces, with bulk jars sealed and out of reach from unauthorized staff. Emergency protocols and staff training remain key: quick, informed responses to incidents matter for all chemicals in this class. Disposal of waste or expired lots routes through certified hazardous materials processing, making sure residues do not leach into water or landfill. Regulatory reporting for any losses or spills maintains full compliance and accountability, and also protects workers.
Drug makers value Zolpidem L-( )-hemitartrate for its performance, but environmental and workplace safety stays in the conversation for any raw material with psychoactive potential. Regular audits, improved ventilation in handling areas, and updated PPE (personal protective equipment) policies answer concerns about accident risks and inadvertent exposure. Automation steps in for large-scale blending and packing to push people away from direct contact when scaling up operations. Smart labeling with traceable barcodes locks down control over every bottle and shipment, preventing diversion or confusion with similar-looking raw materials. On the production line, closed systems for measuring, transferring, and blending Zolpidem L-( )-hemitartrate keep dust levels low, making facilities safer and cleaner.
Zolpidem L-( )-hemitartrate takes up an essential space in the toolkit of pharmaceutical raw materials, balancing chemical stability, workable density, and strong performance for formulated sleep aids. Even with generations of safe use, every level of the supply chain—chemists, handlers, transporters—carry the duty to know its risks and best handling steps. High standards, thorough paperwork, and regular workplace training hold together the safety net around this important, sometimes sensitive, material. By keeping conversations about chemical properties, material safeguards, and safe disposal front and center, the whole field can keep offering the benefits of advanced drugs while locking down both personal and environmental safety.
Providing high-quality chemical products and logistics solutions for global trade partners.
