S-(-)-Tert-butylamino-1,2-propanediol stands as a resolved chiral compound, recognized for its place in the world of raw materials, specifically in both fine chemicals and pharmaceutical research. With a molecular formula of C7H17NO2, you’ll find this compound often uses a tert-butyl group and amino functional group to deliver the properties synthetic chemists look for in beta-blocker intermediates and chiral building blocks. Its structure brings together a tert-butylamino attached to a 1,2-propanediol backbone, setting the scene for reliable stereochemistry and chiral integrity.
Real-world encounters with S-(-)-Tert-butylamino-1,2-propanediol reveal a compound that comes as a solid, usually offering itself up as white to off-white flakes, powder, or crystalline mass. The density sits around 1.03 g/cm³, a value that calls for careful handling in both dry and solution forms—be it for scaling up in drums or prepping precise lab-scale work in milligram vials. The melting point typically lands in the 46-49°C range, helping define the right temperature for storage and application. Some vendors provide it in solution by the liter. In solution, it dissolves smoothly in water due to the presence of hydroxyl groups, qualifying as a polar molecule, yet it doesn’t stray far from a solid feel until it hits direct heat.
Look at the skeletal formula, and you’ll spot a three-carbon chain with a hydroxyl group at each end and a tert-butylamino group set on the center carbon. The IUPAC name, (2S)-2-(tert-butylamino)-1,2-propanediol, signals both configuration and substituents. With a molecular mass around 147.22 g/mol, you’re handling a substance whose chirality forms the basis for many asymmetric syntheses. Its S-(-) configuration ensures the stereochemistry matches what’s needed for targeted pharmaceutical activity, especially relevant in industries working under regulatory scrutiny.
Specifications for S-(-)-Tert-butylamino-1,2-propanediol often detail a purity above 98%, with loss on drying and residue on ignition reported for industrial customers and academic users alike. The substance qualifies for import and export under the Harmonized System Code (HS Code) 2922199090, which covers other acyclic amines and their derivatives. It is tracked under not only chemical inventory lists but also transport documentation. Appearance ranges from fine powder suitable for reaction setups to dense crystals measured for structural analysis. Its consistency supports reliable analytical and production chemistries, particularly in regulated supply chains.
I’ve worked in labs where chiral selectors or intermediates shape up entire research projects. S-(-)-Tert-butylamino-1,2-propanediol fits into this landscape as a core scale-up substance for chiral pharmaceuticals—like beta-blockers, or as starting material when constructing more complex amino alcohols. Its flexibility shows in the way it combines with other raw materials to yield new stereocenters, both in batch and continuous setups, and its solid form means minimal dust if weighed carefully. Selling by the kilogram or in small vials lets suppliers and end-users alike dictate their scale, always making note of density, batch consistency, and lot integrity.
Safety takes priority. S-(-)-Tert-butylamino-1,2-propanediol must be labeled as hazardous, supported by GHS precautionary statements on every package moving through the warehouse or being poured into a flask. The presence of amino groups and secondary alcohols means that skin contact and inhalation should be avoided. Gloves, goggles, and well-ventilated workspace aren’t optional. Material Safety Data Sheets document both acute hazards and any chronic health impact—always referenced in my workplace as part of standard protocols. Safe storage calls for sealed, moisture-proof containers, kept in a cool, dry location, away from strong oxidizers or acids. Spills cleaned with absorbent materials and proper waste labeling keep the workspace compliant and prevent harmful exposure.
Leaning on years of lab experience, one lesson always stands out: waste streams from amino alcohols demand special treatment. S-(-)-Tert-butylamino-1,2-propanediol shouldn’t hit regular drains. Facilities should use dedicated hazardous waste containers, marked for amine-containing materials. Local and federal regulations often highlight the need to avoid accidental release, both from a safety and environmental point of view. Employees get routine training on emergency procedures because inhalation and accidental ingestion can cause irritation or more severe symptoms. Lab managers stress leak-proof packaging and up-to-date documentation for every bottle on the shelf or shipment on the road.
Factories and research teams can strengthen safety outcomes by investing in automated dispensing solutions and leakproof package formats, especially for kilo-scale distribution. Inventory tracking with barcoded chemical management systems helps cut losses and trace exposure. In highly regulated industries like pharmaceuticals, every lot passes through identity and purity testing, which roots out substandard batches before they ever get into larger production workflows. Investment in training and PPE always pays off, as even the best raw material creates risk if handled carelessly. Supply chain partners who focus on clear batch labeling, current HS documentation, and full transparency remove confusion and make global distribution safer for people and the environment.
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