Every so often, a structure comes along in the chemical world that gets attention for more than just its name. [(S)-(E)]-2-[3-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]-Phenyl]-2-Propanol falls into this category not for branding, not for market push, but for the type of work it quietly does in the background of chemical research and pharmaceutical development. This compound pulls together several unique chemical groups in one molecule: a quinoline ring, a hydroxypropyl tail, and a phenyl group all stitched together along with a distinct stereochemistry that points to highly specific interactions. Experience in labs shows that once a material mixes aromatic rings and halogens, as with the 7-chloro-2-quinolinyl moiety, solubility and binding characteristics tend to shift in ways that catch both researchers and regulatory review. It is the kind of molecule that carries weight in drug design, where its features let it slip through membranes or nestle into enzyme pockets that simpler substances cannot touch.
Communities in chemistry recognize how a single atom like chlorine can tilt the scales on reactivity and stability, affecting not just the safety data sheets but the way downstream synthesis works. Materials with this structure enter formulations for advanced research and sit on the edge between synthetic challenge and beneficial application. Practical use of it draws on both the aromaticity and the presence of a hydroxyl group for making strong intermolecular connections. The (S)-(E) configuration also pushes this compound into select shelves: only this configuration gets trialed, avoiding the unpredictable effects that a different orientation might bring.
[(S)-(E)]-2-[3-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]-Phenyl]-2-Propanol calls for a close look at every bond. The molecule stretches outward from a core aromatic ring. Attached through a hydroxypropyl linker, another phenyl ring locks in place, then the long arm of a 7-chloro-2-quinolinyl ethenyl moiety completes the architecture. This isn’t a molecule you sketch out in a minute: real-world experience with such compounds demands careful validation, often through crystallography and NMR, making sure each functional group points the right way. Chemists who handle this kind of material know its bulk influences solubility and phase—easy flow powders or crystalline flakes are typical, though purity kicks in when aiming for sharp melting points or high-yield reactions.
Structurally, a quinoline system often boosts electron density in ways that impact both reactivity and how the molecule fits into complex biochemical networks. The chloro substitution changes not just the weight; it tweaks the molecule’s glide through different solvents, impacting whether it’s best delivered as a powder, suspended as a fine crystal, or pushed into a solution for testing. Those working with it know stability improves in certain airtight containers, avoiding water adsorption that could otherwise cause solid clumps or risk change in stereochemistry.
In the market, this compound shows up as a dense solid, its consistency shifting from fine powder to tiny, glassy flakes depending on how it’s processed and who’s synthesizing it. Next to the benchtop scale, folks notice its faint color—off-white to pale yellow, a typical marker for quinoline derivatives with halogen substituents. Bulk handling means measuring density accurately. Finding it resting between crystalline and powdery states, chemists mark density values around 1.25 to 1.30 g/cm³, flowing tighter than simple organic acids, less than heavy salts. That matters for scaling up and storage: powder likes to fly, flakes want to settle. Crystals, especially pure ones, point to solid synthetic execution and higher yields in downstream use. Pearls and liquids stay as rare forms, given the weight and polarity the structure brings. The substance dissolves well in DMSO, DMF, and, to a degree, in alcohols; water only accepts small amounts without heat or stirring.
Material safety and transportation also depend on these specifications. Standard packaging keeps the compound dry, away from direct sunlight, and in a cool, well-ventilated space. It packs down smoothly, doesn’t cake unless mishandled, and resists decomposition under normal laboratory conditions. Working directly with it, gloves and dust protection stand as a bare minimum, since inhalation or skin exposure could introduce risk—the compound features aromatic rings and halogens, factors closely watched in chemical hazard assessments.
Sourcing and compliance make up another story. The compound fits as an organic intermediate in the international tariff code system. HS Code assignment often lands around 2933.39, reserved for other heterocyclic compounds holding nitrogen in the ring structure that aren’t easily described by everyday catalogues. Those moving this substance across borders expect paperwork and regular checks, plus safety data sheet (SDS) backups. Echoes of past customs hiccups have taught most to secure a full set of COAs and batch records whenever shipping.
Preparation of material like this starts with goods found in a solid chemistry storeroom: reagents for quinoline synthesis, halogenating agents to add that all-important chlorine, and standard aromatic aldehydes and alcohols to build up the propyl and phenyl moieties. Those who’ve worked up the chemistry recall how much purity depends on smart planning at each stage—each step holds back unintended isomers or leftover reactants, flaws that show up fast in analytical purity or low bioactivity. Batch-to-batch consistency follows from careful control of starting material and solvents, a lesson that underpins trust in both research and production settings.
The complete molecular formula calls for clarity: C27H24ClNO2. That alone signals a large, highly structured molecule, the kind that pushes against simple purification and storage approaches. The molecular mass, tipping in just above 430 g/mol, tells those working in formulation to expect slower dissolution and extraction when scaling up tests or prepping for clinical trials. The melting point typically ranges from 158°C to 164°C, sometimes with variability depending on residual water or minor solvent traces—common in multi-step synthesis but critical for those managing QA.
Practical chemists take the numbers into every aspect of the process. Specific gravity hovers just above unity, sitting well in standard storage but requiring care around temperature spikes. In solution, its reactivity stays low under ambient handling, though oxidation and hydrolysis under strong basic or acidic conditions draw most of the caution. That’s why all product literature lists complete storage and disposal instructions, underscoring a culture of safe, repeatable handling that prevents exposure both for lab workers and for the environment.
Those of us who spend long hours around chemicals know which ones need extra respect. This compound, for all its valuable potential, checks several boxes that raise eyebrows. The quinoline ring sets off toxicology alarms, with halogens like chlorine bringing both antimicrobial effects and risks of acute irritation or chronic exposure symptoms. Over the years, documentation around quinoline-derived pharmaceuticals reminds us that even small molecule intermediates can create unpredictable biological interactions. Safety sheets warn against inhaling the dust, splashing solutions, or making accidental contact with skin and eyes. Long-term storage requires good labeling and, ideally, keeping amounts on hand as low as practical for the work at hand.
Waste from synthesis should never go down the drain. Containers marked for hazardous waste, handled under local environmental regulations, cut down the risk of water contamination or hazardous vapors. Adequate air handling—good fume hoods and proper PPE—turn what could be a risky experiment into another safe day at the bench. Regular reviews of material safety data keep everyone honest about changing best practices, whether refining synthetic routes, reformulating products, or just updating storage cabinets. Up in regulatory affairs, compliance teams keep an eye out for any new listing of related substances under REACH, TSCA, or CLP. Researchers, production staff, and those writing new monographs all give this compound the level of attention any potentially hazardous chemical calls for, based on both published studies and the sort of practical working knowledge that builds up lab by lab, year by year.
Providing high-quality chemical products and logistics solutions for global trade partners.
