Known in the world of organic chemistry for its elaborate structure and complex synthesis, (S)-(E)-2-[2-[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYLPHENYL]-3-HYDROXYPROPYL]PHENYL]-2-PROPANOL draws attention from pharmaceutical scientists and chemical engineers. Its molecular formula, C28H24ClNO2, and molecular weight, which clocks in around 441.95 g/mol, make it a heavyweight among specialty intermediates. The backbone features a propanol chain, phenyl rings, and a prominent quinolinyl group fitted with a chlorine atom at the 7-position. Chemists gravitate to this molecule because it ticks boxes for structural chirality, electronic properties, and reactivity sites.
You will not find (S)-(E)-2-[2-[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYLPHENYL]-3-HYDROXYPROPYL]PHENYL]-2-PROPANOL sold in large drums or barrels like commodity chemicals. Instead, it appears in small batches, often as a solid powder or crystalline flakes, depending on handling and storage. The flakes range in color from off-white to pale yellow, revealing subtle impurities or minor batch-to-batch variation. Density hovers near 1.30 g/cm³, a consequence of the stacking aromatic rings and chlorine atom, which provide bulk.
Anyone trained in organic chemistry will recognize the compounded complexity brought by the conjugated quinolinyl-ethenyl-phenyl system. The (S)-enantiomer reflects a precise chiral configuration, not just a trivial detail, but a property that commands attention when pharmaceutical activity enters into manufacturing or research. The (E)-geometry at the ethenyl bridge ensures the molecule’s substituents stay across from each other—a geometry that can change biological behavior and reactivity. The presence of a hydroxyl group on the hydroxypropyl side chain injects hydrogen bonding potential, shaping both solubility and reactivity. Solubility in common organic solvents—such as dichloromethane or chloroform—is good. Water solubility is limited, which comes as no surprise if you’ve handled chlorinated aromatic materials in the lab.
Suppliers deliver this material to contract manufacturers chiefly as a reagent for advanced drug synthesis. Specification sheets highlight high purity (over 98%), trace organic solvents below 0.5%, and negligible heavy metal content. Particle size varies from fine powder to larger crystalline pearls, depending on drying conditions and preparative route. Temperature-resistant vessels suit preparation and transport, as the compound’s stability can waver near prolonged exposure to above 120°C. The raw materials list reaches beyond simple benzene derivatives and extends to specialty quinolinyl chlorides, ethenyl coupling agents, and protected aryl alcohols. Each synthetic step demands care with both glassware and controls, since contamination or racemization impacts the product’s value.
A look through NMR spectra shows distinct peaks for aromatic protons and the hydroxy-functionalized positions, giving chemists markers they need to check structure. Mass spectrometry shows a pronounced molecular ion cluster reflecting the chlorine isotope distribution (35Cl and 37Cl). Chromatography details reveal distinct retention, confirming the single, pure enantiomer when proper chiral columns are employed. Researchers lean heavily on IR spectra, using carbonyl and phenyl region peaks, plus O-H stretching as proof of structure during quality checks.
Bench chemists who work with (S)-(E)-2-[2-[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYLPHENYL]-3-HYDROXYPROPYL]PHENYL]-2-PROPANOL appreciate both its promise and its quirks. Storage requires temperature and humidity control. The material doesn’t flow like a free liquid, won’t clump excessively, but tends to require gentle agitation to prevent caking at scale. Glass ampoules or amber bottles keep the compound away from UV light and reactive moisture. This material enters research as a precursor for synthetic drugs, specifically where selectivity at aromatic and hydroxy sites stand critical. Small-scale production focuses on purity and precise chiral excess. At industrial scale, attention swings to yield maximization and solvent recovery. The HS Code most commonly referenced for this sort of fine organic pharmaceutical intermediate is 2933.39, pointing to heterocyclic compounds with nitrogen hetero-atom(s) only.
Caution stands as the rule for use and transport. Personnel handle the compound as a potentially hazardous substance because of the chloroquinolinyl group, which can irritate the respiratory tract and skin. The powder poses inhalation concerns with long exposure. Appropriate PPE—respirator masks, safety goggles, and nitrile gloves—remains the norm. Spill response means wet-wiping rather than sweeping, as dust easily becomes airborne. Material safety data sheets identify the product as harmful in large doses, not acutely toxic but requiring responsible waste management, including collection and incineration consistent with organic halogenated materials. Laboratory waste should never go down drains; collection and professional disposal cut risks. Environmental persistence, mainly from the quinoline ring’s stability, underscores the need for adequate destruction by thermal means above 800°C in industrial facilities.
Reducing hazards starts with cleaner synthesis routes and more robust purification. Researchers track safer alternatives for chlorination steps. Newer catalytic systems, aiming to cut down on waste and hazardous byproducts, gather interest but need scale-up studies. Manufacturers improve worker safety by automating powder transfer, containing storage, and emphasizing local exhaust ventilation. Training programs help staff recognize symptoms of exposure and lead to early intervention.
(S)-(E)-2-[2-[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYLPHENYL]-3-HYDROXYPROPYL]PHENYL]-2-PROPANOL occupies a demanding slot in research and pharmaceutical synthesis. Each feature—from the hydroxypropyl side chain to the quinolinyl ring—brings specific handling challenges and safety needs. Practical experience with this specialty intermediate reveals the importance of robust supply chains for pure raw materials, modern lab safety infrastructure, and progressive environmental policies for waste minimization. At every step, a thorough understanding of its structure, density, physical form, safety risks, and use cases uncovers why it attracts so much technical interest and regulatory care.
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