(S)-Alpha, Alphal-Diphenyl-3-Pyrrolidineacetamide L-Tartaric acid salt combines a chiral amide with the natural L-tartaric acid, often found in synthesis labs working on cutting-edge compounds. In the space of chemical development, this salt shows up for its strong stereochemical purity, making it valuable when high selectivity matters. Chemists rely on molecules like this in asymmetric synthesis, which drives forward small molecule drug discovery and fine-tunes specialty chemical processes. People looking into pharmaceutical intermediates run across such salts because of their impact on reaction outcomes where the right-hand version of a molecule works while the left-hand one does not. Manufacturing needs grow, and so does the reliance on compounds where every atom counts, and small structural differences shift entire outcome possibilities.
Looking at its structure, the molecule features a pyrrolidine ring, two phenyl groups, and an acetamide side chain. Its L-tartaric acid component carries two hydroxyl groups and two carboxylic acid groups arranged specifically in space, conferring distinctive solubility and reactivity properties. This arrangement matters in practice. Synthetic chemists recognize that its particular three-dimensional configuration gives rise to chirality, separating it from many laboratory workhorse reagents. The salt formation improves stability, manages potential volatility, and often enhances safety and storage characteristics compared to the free base or acid forms. While some might overlook the effect of chirality and salt formation on daily operations, those who work hands-on with these materials see direct benefits, from better yields to more predictable purity.
This salt presents itself in solid form, commonly appearing as white or off-white powder, occasionally forming crystalline flakes, and sometimes setting into small pearls depending on drying and recrystallization methods. In laboratory settings, people find the solid state simple to handle, easy to measure, and less prone to accidental inhalation than fine powders, although standard best practices for chemical handling always apply. Density typically falls around 1.3 to 1.4 g/cm³, which lines up with many similar organic salts, making for familiar handling and measurement. The crystalline nature gives it a consistent melting point (usually near 160-170°C), which lab staff use as a quick check for identity and purity.
Handling chemicals like this always brings safety high on the priority list. As with most organic amide and tartaric acid derivatives, this salt does not usually present high acute toxicity under standard laboratory conditions, but ingestion, inhalation, or direct contact is still best avoided. The solid is poorly volatile, reducing inhalation risks, and does not form hazardous fumes under standard room conditions—a relief during busy weighing and transfer sessions. Spillage still calls for prompt clean-up because even relatively safe chemicals pile up risks when proper protocols fall by the wayside. Some may experience mild irritation upon skin contact, so gloves and goggles remain a must. MSDS information for this molecule, sourced from reliable chemical suppliers, usually lists it as an irritant. Accidental release into the environment or water system needs to be minimized, and staff must keep it away from strong oxidizers and acids to avoid unwanted reactions. Safe laboratory practice, solid waste disposal adherence, and good ventilation tie together a safe workflow while handling it.
The salt contains carbon, hydrogen, nitrogen, and oxygen from the diphenyl-pyrrolidineacetamide, along with the same atoms from L-tartaric acid. Combined, the typical molecular formula reads C20H22N2O2·C4H6O6, but batch-specific variants and water content sometimes lead to minor differences, visible in batch-specific certificates of analysis. The molecular weight typically lands between 468 and 502 g/mol, depending on the precise salt stoichiometry and trace water. This level of clarity aids procurement teams and quality control professionals to match their paperwork and analytical certificates, avoiding purchasing mistakes that create project delays. HS Code classification often falls under 2924.29 (organic amides), making customs clearance straightforward for experienced import and export teams.
This compound stands as a backbone for further synthesis in medicinal chemistry and small-scale process manufacturing. Labs often reach for it when aiming to synthesize chiral drugs or specialty materials that demand a specific three-dimensional configuration to function. Biological activity in drug molecules depends heavily on stereochemistry, which means that starting with a chiral salt like this can mark the difference between an effective product and one that fails. Teams working on new drug molecules or crop protection chemicals view this material as a foundation stone, not just an optional extra. Its presence in critical steps shows up in patent disclosures, regulatory filings, and scientific literature, reflecting its value across research and industrial practice.
Production typically involves the careful reaction of (S)-alpha, alphal-diphenyl-3-pyrrolidineacetamide with L-tartaric acid in an appropriate solvent, followed by filtration and carefully controlled drying. Storage in tightly sealed containers, away from humid or strongly heated environments, protects both the salt’s integrity and occupational safety. Degradation can show up as color change, caking, or loss of crystallinity—a signal for the quality control team to reject subpar material. The powder’s flow properties and morphology can affect how easily it transfers into reactors or weighing stations, and people who’ve fought with sticky or hygroscopic batches know the headache of poor material handling. Good packaging, sturdy drums or HDPE bottles, delivered with supporting analytical paperwork, reduce risks from the moment of delivery onward. Shipping compliance for organic chemicals, including proper labeling per GHS and transport regulations, ensures that materials safely reach labs worldwide.
Every chemical brings challenges, and this salt is no different. Supply chain disruptions risk stalling programs that rely on unique building blocks for chiral synthesis. Maintaining high stereochemical purity and batch consistency often tests raw material suppliers, with chromatographic and spectroscopic analyses ensuring the right product lands in the hands of end users. There’s also the matter of cost—sourcing from vendors with a reputation for reliability can push up expense, but those with practical experience know that cheap, off-spec materials only hurt a project. Teams facing quality problems with this raw material have solved them by implementing tighter vendor qualification, incoming analytical verification, and collaboration with suppliers for custom specifications. Waste management remains important; the molecule doesn’t rank among the most hazardous chemicals, but responsible disposal routines protect both staff and environment, cementing trust and compliance in regulated settings. In my own work, tight organization and clearly labeled containers transformed our lab’s workflow, reducing mix-ups, speeding up synthesis, and improving output quality. Anyone in the business of chemical or drug development learns quickly that success depends on both the right substances and the systems supporting their use.
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