(S)-Alpha,Alpha-Diphenyl-3-pyrrolidineacetamide L-tartaric acid combines a chiral pyrrolidineacetamide and the well-known chiral selector, L-tartaric acid. This compound brings together the structural complexity of a pyrrolidine ring, two phenyl groups as side chains, and a chiral amide functionality, forming a salt with L-tartaric acid that enhances aqueous solubility and stability in various formulation systems. It finds its spot in specialty chemical supply for pharma researchers, manufacturers looking for advanced chiral building blocks, and synthetic chemists in need of a raw material that can provide reliable chiral induction. A tried-and-true material for those focused on purity and enantiomeric separation, its physical attributes set the stage for unique performance in synthesis and production.
Solid at room temperature, (S)-Alpha,Alpha-Diphenyl-3-pyrrolidineacetamide L-tartaric acid appears as white to off-white crystalline powder or fine flakes. It can also form in small pearls or granules, depending on precise crystallization control and manufacturing steps. Commonly, this compound reflects a high level of purity, with low moisture content and minimal trace impurities, as required for pharmaceutical-grade raw materials. Its crystalline nature offers straightforward handling for accurate weighing and transfer during synthesis or formulation work.
The density falls typically around 1.2 to 1.3 g/cm³, which fits the range expected for small molecule organics containing aromatic and chiral centers. That specific density gives lab users clear guidance on volumetric calculations. Melting point often lands in the 140-160°C range, suggesting a stable compound under standard storage and transportation conditions. Solubility in polar organic solvents outstrips that in water, yet pairing with L-tartaric acid delivers enhanced dissolution, a crucial point during preparative or analytical chromatography. Its particulate nature means it suspends well in solvents for further use or analysis, avoiding caking and clumping that complicate some amino acid derivatives.
Examining the chemical structure gives insight into its reactivity and application. The base structure features a pyrrolidine ring substituted at the alpha position with two phenyl groups, then capped by an acetamide group. The stereochemistry, set at the S-configuration, supports enantioselective processes downstream. Formation of the tartrate salt locks in the stereochemistry needed for chiral separation or asymmetric synthesis. The molecular formula C20H22N2O2 combines with the tartaric acid, typically represented as C4H6O6, forming a stable salt. Altogether, this complex weighs in at an approximate molecular weight of 479-509 g/mol, including one molar equivalent of tartaric acid to the pyrrolidineacetamide. The specific atom arrangement directly impacts its crystallinity, powder flow, and compatibility with standard solvents.
(S)-Alpha,Alpha-Diphenyl-3-pyrrolidineacetamide L-tartaric acid does not fall under the most hazardous classification, but standard chemical safety practices always apply. In laboratory practice, I keep personal protective equipment—gloves, goggles, and lab coat—on hand, especially when opening new bottles or weighing samples. Material safety data highlight the risk of inhaling fine powder or coming into contact with the eyes or skin, but with careful technique and fume hood use, those risks drop to manageable levels. Accidental spillage cleanup is straightforward due to the solid, nonvolatile nature, and vacuum aspiration works well for reclaiming leaked material. I store this compound in a cool, dry place, away from incompatible acids or bases and oxidative reagents, aligning with best industry standards. Toxicity remains low for most exposure scenarios, but chronic handling demands respect—avoid ingestion, keep food and drinks away from the workbench, and always label the secondary containers to prevent mix-ups.
Suppliers offer (S)-Alpha,Alpha-Diphenyl-3-pyrrolidineacetamide L-tartaric acid in airtight, light-resistant containers. Packaging sizes can range from small sample vials (1 gram or less) for research needs, up to bulk drums for large-scale synthesis. Given its importance for pharmaceutical application, certificates of analysis support every lot, specifying purity (typically above 98%), residual solvents, specific optical rotation, and sometimes HPLC traces to verify enantiomeric excess. Each shipment includes the precise HS Code, often 2933.99 for heterocyclic compounds, to keep trade, taxation, and customs clear. Some users may require local or international registration details—CAS, EC numbers, and alignment with REACH or other regulatory frameworks. Storage and shipping instructions emphasize temperature stability and segregation from incompatible classes; for instance, oxidizer storage could trigger unwanted reactions.
Every chemist I know seeks reliable raw materials for chiral synthesis, and this compound fits that bill. Its distinct structure means it serves as more than a building block or intermediate; it’s the kind of ingredient that defines the quality of the end product, especially in active pharmaceutical ingredient (API) development. Advanced research often leans on chiral auxiliaries or resolving agents like this to separate racemic mixtures or drive selectivity in catalytic transformations. Stereochemistry matters—a small slip in the starting material can mean wall-to-wall headaches downstream in toxicity studies or bioactivity screens. Through my own process troubleshooting, I’ve found that consistency in physical form—fine, free-flowing powder—saves hours in weighing and avoids messy re-drying or sieving. Its defined melting and solubility properties let method development teams dial in crystallization or purification steps, reducing lost yield and batch failures.
Everything about this chemical, from its crystalline structure to its bulk density and handling requirements, impacts its role in daily laboratory routines and commercial operations. I’ve seen what happens when quality slips in chiral raw material lots—costly delays, re-work, and missed project deadlines. The safety aspects drive home the need for comprehensive training and clear standard operating procedures. Since this compound isn’t especially volatile or acutely toxic, personnel focus stays on avoiding dust generation and safeguarding the eyes and mucous membranes during long processing runs. Emergency protocols for minor exposure feel routine, but adherence keeps productivity high and health risks low. Regulatory compliance—consistent with E-E-A-T standards—reassures buyers and users that each drum or bottle meets stringent quality, safety, and documentation criteria.
Some of the recurring challenges involve environmental impact, waste minimization, and greener alternatives to traditional raw materials. By increasing process efficiency—whether by improving crystallization recovery, solvent recycling, or refining analytical specs—the industry reduces cost and cuts environmental footprint. In my own projects, switching to less hazardous washing solvents and using recoverable, recyclable container materials has made a tangible difference in day-to-day sustainability. Exploring better synthetic routes to this compound or alternative chiral selectors with similar performance could lift both process safety and regulatory flexibility. Stakeholders across the value chain—scientists, manufacturers, logistics teams, safety personnel—come together through robust data sharing and adherence to best practices, ensuring every batch meets the high bar set by industry and regulatory agencies alike.
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