(S)-Alpha,Alpha-Diphenyl-3-Pyrrolidineacetamine L-Tartaric acid salt, a compound found in both chemical synthesis settings and pharmaceutical research, has drawn interest for its unique structure and reactivity. The chemical presents itself as a combination of a pyrrolidine-based amine and a diphenyl moiety, paired as a salt with L-tartaric acid, adding distinct physical hydration and solubility features. Researchers count on this material in solid form, often as off-white to pale yellow flakes or crystalline powder. Density sits close to 1.22 g/cm³, giving it a substantial but manageable mass for lab handling. Its molecular formula, C20H21NO·C4H6O6, shows the L-tartaric acid backbone combined with the chiral amine, forming a 1:1 salt that is easily weighed out or dissolved as a stock solution in controlled conditions.
In storage, (S)-Alpha,Alpha-Diphenyl-3-Pyrrolidineacetamine L-Tartaric acid salt remains stable in dry, room-temperature conditions, away from direct sunlight and sources of moisture. In my own lab work, handling this type of salt calls for simple PPE: gloves, standard working lab coat, and care not to inhale dust when weighing or transferring. The crystalline material resists melting at room temperature but will transition to liquid at elevated heat, generally above 180°C. Solubility leans toward polar solvents; ethanol, methanol, and water all dissolve the salt, giving clear solutions for titration or reaction use. Reactivity levels remain moderate under normal lab circumstances, but adding strong acids or oxidizers can start decomposition, releasing irritant vapors. L-tartaric acid salt formation brings both enhanced purity and manageable handling compared to the free base, making batch work smoother for synthesis.
Peering at its structure under spectroscopy, it shows a distinct three-dimensional shape defined by the configuration of the (S)-alpha carbon and the tartaric acid moiety wrapped securely with hydrogen bonding. Commonly referenced in NMR as well as X-ray crystallography, the salt’s stereochemistry keeps it desirable for use in chiral resolution steps, where orientation in space does not just matter, but dictates downstream biological activity. The molecular makeup supports customization in medicinal chemistry, allowing for functional group modification on either the aromatic rings or the pyrrolidine body to explore new derivatives.
Reputable suppliers usually offer this salt with a purity of 98% or higher by HPLC and specific rotation values confirming the (S)-stereoisomer. Moisture content typically remains under 0.5% following Karl Fischer titration, and individual batches come with a certificate of analysis listing impurities, melting point (180-185°C), and appearance conformity. Particle size varies by route of crystallization, ranging from fine powder form (40 to 100 mesh) to slightly chunkier flakes, making it easy to weigh for small-scale or pilot runs. The salt’s density aids solvent dissolution, allowing for accurate preparation of high concentration solutions for scale-up experiments or trials.
Shipping and regulatory compliance fall under Harmonized System Code 2933.39.9090 for “heterocyclic compounds with nitrogen hetero-atom(s) only.” Proper classification matters for customs and handling notices. While the material is not classed as highly hazardous or acutely toxic, standard chemical hygiene practices apply. The salt may irritate eyes, skin, or respiratory tract on direct contact. Anyone moving bulk lots or blending high-percentage powders should use dust control, eye protection, and reliable ventilation since inhalation is the most likely route of exposure. Fire and disposal risks remain low, provided strong oxidizers or acids are not involved, and typical chemical waste streams absorb minor unused quantities. Emergency responders and shipping teams rely on clear, GHS-compliant labeling, including all pictograms for irritant and harmful hazards as assessed by the Global Harmonized System for chemical labeling.
Anyone working with medicinal chemistry or analytical research will recognize this salt among the more reliable building blocks for chiral amine synthesis. The salt’s solubility in both water and organic alcohols lets chemists carry out straightforward solution-phase reactions, with more confidence in batch purity and reproducibility. In practice, using L-tartaric acid as the acid component confers established reliability, as the tartrate salt assists in resolving enantiomers and keeping recrystallization steps efficient, minimizing racemization risk. Throughout production, material in powder, pearl, or crystal form can be directly charged into reactors or formulation bins, skipping extra dissolution stages that other chemical urinals demand. Factories blending multi-step syntheses use this salt as a primer or stage intermediate, cutting down reaction feeds that often need more costly and less user-friendly alternatives.
In my chemical inventory work, raw materials that combine manageable hazard profiles with bulky solid form come with advantages for daily workflow. (S)-Alpha,Alpha-Diphenyl-3-Pyrrolidineacetamine L-Tartaric acid salt fits that category—a crystalline solid, not a volatile liquid or sticky semisolid, stacks cleanly on the shelf, ships without specialized containment, and is not flagged as a major environmental hazard under current US and EU chemical inventories. Spills, though rare, clean up with scoop and wipe without major incident, provided surfaces are dry. Good chemical stewardship means keeping each lot labeled by date and batch, training all users on proper weighing, and returning leftovers promptly to the original container to prevent cross-contamination. While not immune to mishap, materials like this salt rely more on basic clear-headed lab habits than elaborate safety interventions.
As a component in pharmaceutical or specialty chemical development, this salt stands out for doing the heavy lifting in chiral filtration or as a stepping stone toward more complex bioactive targets. I’ve seen research teams turn to (S)-Alpha,Alpha-Diphenyl-3-Pyrrolidineacetamine L-Tartaric acid salt for making custom reagents, then filter and crystallize the result with smooth recoveries. In broader chemical manufacturing, its ability to serve both as a reactant and a way to introduce chirality streamlines project timelines, promising more cost-effective campaigns and fewer purification headaches. For chemical engineers and process chemists looking to optimize plant throughput and regulatory compliance, working with this salt means focusing on consistent supply, secure storage protocols, safe disposal, and clear documentation of its movement in and out of the raw material bins.
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