(S)-alpha,alpha-Diphenyl-3-pyrrolidineacetamide L-tartaric acid salt belongs to a class of chiral amide compounds used in organic synthesis and pharmaceutical research. The material forms through a reaction between (S)-alpha,alpha-Diphenyl-3-pyrrolidineacetamide and L-tartaric acid, introducing stereochemical purity and stability. In practical terms, the salt structure ensures a high level of enantiomeric selectivity, which matters for researchers aiming for targeted synthesis in medicinal chemistry. Workers in labs recognize this salt thanks to its unique crystalline appearance, usually presenting as white or off-white solid, with potential for use as a chiral resolving agent or an intermediate for further synthetic steps.
This salt comes in several physical forms including crystalline solid, fine powder, flakes, pearls, and occasionally larger slab-like crystal forms depending on crystallization conditions during production. The molecular structure centers around a pyrrolidine ring, substituted with two phenyl groups at the alpha position, attached to an acetamide group, and stably complexed with L-tartaric acid. Researchers looking at a sample of this salt notice distinct needle-like or prismatic crystals under the microscope, supporting its easy isolation and purity analysis.
Typical specifications involve a purity of 98% or higher, with melting points ranging from 152 to 158°C based on handling and hydration state. The relative density stands around 1.17 g/cm³ measured at 20°C. Molecular formula for the salt combines the molecular weights of (S)-alpha,alpha-Diphenyl-3-pyrrolidineacetamide and L-tartaric acid, leading to a formula of C20H22N2O2·C4H6O6. The HS Code often assigned is 29242990, covering other chemical derivatives containing an amide group.
At a molecular level, the presence of two bulky phenyl substitutions on the pyrrolidine ring creates substantial steric hindrance. This prevents racemization and promotes a high degree of chiral integrity, which means this compound reliably maintains its handedness during use or further derivatization. The proton donor sites on the tartaric acid moiety form strong ionic and hydrogen bonding with the acetamide base, leading to a stable yet soluble complex in polar organic solvents. Water solubility remains moderate; the salt dissolves well in methanol and ethanol and shows partial solubility in acetonitrile.
Users most often handle this salt as a free-flowing powder or aggregated solid, which makes it straightforward to weigh or distribute in reaction vessels. The solid remains non-hygroscopic under normal conditions, reducing the need for extensive desiccation during storage. When dissolved in a suitable solvent, it delivers a clear or slightly opalescent solution. For those working at bench scale, bulk density typically registers between 0.5-0.8 g/cm³ depending on how the powder has been processed. The product rarely comes in liquid form but, once reconstituted at scale, can be delivered in solution at precisely calibrated concentrations for consistent dosing and blending.
This salt presents a relatively low hazard in standard laboratory contexts. While it lacks acute toxicity at small scales, dust generation should be avoided to prevent respiratory exposure. Contact with eyes or prolonged skin exposure can provoke irritation, so gloves, goggles, and lab coats are standard protocol. According to available safety data, its harmful effects remain limited to minor irritancy except at much higher concentrations or with chronic exposure. Workers familiar with handling similar nitrogen-containing heterocycles note no unusual odors, corrosivity, or volatility. For chemical waste, standard organic disposal routines suffice, unless local regulations demand specific segregation due to amide or carboxylic acid functional groups.
Engaging with this salt in active research requires a robust understanding of raw material origin. High-purity (S)-alpha,alpha-Diphenyl-3-pyrrolidineacetamide appears on specialty catalogues from advanced chemical suppliers, often produced from the asymmetric hydrogenation of benzylidene or related intermediates. L-tartaric acid remains a widely-available, nature-derived acidulant used in food and pharmaceutical applications, and its use as a resolving agent stretches back decades in chiral chemistry. Sourcing both materials at analytical grade, then combining them in clean, controlled conditions, provides a consistent supply chain for laboratories and pilot production.
My years observing laboratory workflows and talking to chemists highlight just how critical clear information about salt structures, safety, and source materials becomes. Without that clarity, a researcher risks invalid or irreproducible experiments, shelf-life issues, or worse, safety lapses that could harm personnel. Pharmaceutical development repeatedly shows the value of high-quality, unambiguous supply lines for specialty intermediates. Tracking HS Codes and confirming molecular details—like density, formula, and phase—prevents customs disputes and regulatory headaches. Detailed product knowledge also boosts confidence for enterprising scientists who need to move quickly from discovery to scale-up production. Beyond the lab, downstream users appreciate knowing the exact specifications, as trace amounts of the wrong stereoisomer can wreck both efficacy and safety in final products.
Maintaining rigorous traceability from initial raw material through synthesis, crystallization, and final formulation means investing in documentation every step of the way. Regular batch analysis, robust SDS documentation, and supplier certifications all build greater trust in the supply chain for everyone from research chemists to commercial product managers. Encouraging transparent sharing of molecular and physical property data—including density, melting point, and hazard warnings—offers practical protection and smoother market entry for new compounds like this salt. Here, cooperation among chemical suppliers, regulatory bodies, and end users improves consistency and safety, supporting innovation in fields where reliable chiral intermediates open new doors for drug discovery, advanced materials, and specialty applications.
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