(S)-(-)-3-(tert-Butylamino)-1,2-propanediol carries weight in the world of organic synthesis and pharmaceutical raw materials. Its reputation comes not just from its molecular layout but from a combination of properties making it significant for those working in chemistry, materials science, and medicine. Its IUPAC name tells you about its structure, reflecting a chiral entity with an S-enantiomeric form. The product appears in labs as a crystalline solid or sometimes as a fine powder — this tends to depend on purity and method of crystallization. The presence of both amino and diol groups means it brings a blend of hydrophilicity and moderate basicity to the table, lending itself to a range of potential applications.
The molecular formula stands as C7H17NO2. Looking closer, its structure features a tert-butylamino group at the third position of a 1,2-propanediol backbone. This gives it both a secondary amine and two alcohol groups within a fairly compact molecule, allowing different chemical reactions compared to simpler analogs. The specific spatial arrangement, dictated by the S-configuration, makes it relevant in asymmetric synthesis and situations where handedness in a molecule decides the outcome. Its molar mass measures about 147.22 g/mol, important for precise dosing in any chemical preparation.
Colorless to slight off-white in appearance, this compound takes on various solid forms; flakes, powders, and sometimes small crystalline pearls, each suited for distinct application methods. As a solid, it stays stable under typical storage conditions — dry, cool, and away from direct light. Melting point clocks in near 54°C to 56°C, a clue helping chemists with identification and purity checks. Density hovers around 0.99 g/cm3, making it comparable to water, which simplifies certain lab processes. Solubility in water is notable, and solvents like ethanol or methanol accept it easily. In solution, transparency and stability over reasonable periods help with consistent outcomes in both research and production.
Globally, the handling and shipping of chemicals require precise documentation. (S)-(-)-3-(tert-Butylamino)-1,2-propanediol usually falls under HS Code 2922199090, categorized as a “heterocyclic compound with nitrogen hetero-atom(s) only,” as interpreted in many international chemical inventories. Those working with logistics or exports face strict documentation and must declare quantities, packaging, and chemical hazards closely aligned with this code to prevent regulatory headaches. Country-specific regulations may trigger additional safety sheets or prior-notice obligations for both large and small shipments.
This molecule’s versatility comes from its reactive groups — a secondary amino and two adjacent alcohols. It can serve as an intermediate for active pharmaceutical ingredients, particularly beta-blockers and other cardiovascular drugs, where stereochemistry can dictate therapeutic value. Its alcohols react with acyl groups, while the amino group engages in alkylation or reductive amination. For synthetic chemists, keeping the S-configuration intact during reactions matters more than speeding up yields. The molecular stability in the presence of mild acids and bases supports its role in multi-step synthesis. On the shelf, it resists rapid breakdown, so a properly sealed container helps avoid unnecessary waste or contamination during storage.
(S)-(-)-3-(tert-Butylamino)-1,2-propanediol does not carry dramatic danger symbols, but no one should take chemical exposure lightly. It can act as an irritant — especially if inhaled as powder, swallowed, or brought into direct contact with skin and eyes. Prolonged or repeated exposure may lead to headaches or discomfort; the best strategy in a lab or manufacturing environment remains sensible personal protective equipment: gloves, goggles, and good ventilation. Washing off accidental contact without delay and labeling all containers sensibly closes off paths to accidental misuse. As a raw material, most of its hazards stem from improper containment — moist environments or high heat may cause gradual loss of product quality rather than acute toxic risk, but that does not give license for carelessness in storage or disposal.
In my own experience, materials like this unlock a range of chemical transformations — the presence of both hydrophilic alcohols and a nitrogen atom in its structure brings choices in reactions that simpler molecules just cannot touch. The S-stereochemistry transforms the story from an ordinary reagent into one demanded for making chiral drugs or asymmetric catalysts. Working with this compound, clarity in labeling, and drawing a line between research-scale use and ton-scale purchase requires cooperation between chemists, suppliers, and transporters. Documented attention to density, form (flake, pearl, powder), and solubility sets up both predictable results and safe workflows in both university and industrial settings.
Every substance, even ones that appear harmless at first glance, needs respect from everyone handling it — accidental exposure, poor documentation, and shortcuts in labeling hurt both worker safety and end-product quality. A sensible approach means training every lab member or factory worker on best storage practices, using closed systems for weighing, and maintaining up-to-date safety data sheets. Waste management policies anchored in current national guidelines keep the risk of environmental contamination low, a lesson learned from countless incidents across the chemical industry. Those responsible for moving raw materials across borders find clear benefit in keeping paperwork accurate, containers clearly marked, and storage secured — small investments that save large costs in prevented incidents and regulatory trouble.
(S)-(-)-3-(tert-Butylamino)-1,2-propanediol’s appeal comes from more than just its molecular quirks — it provides consistent results in making active pharmaceutical ingredients and opens doors in asymmetric catalysis and materials research. Ensuring its continued safe use depends on a culture of care: attention to physical form, handling protocol, and regulatory shifts in each sales market. Facts about crystal habit, solution behavior, or hazard specifics are not just details for paperwork; they become essential for building trust with clients and partners worldwide, and in every case where chemistry supports health, technology, or manufacturing progress, understanding the ins and outs of raw materials makes all the difference.
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