(R)-1-(3-Chlorophenyl)-1,3-propanediol stands out as a white to off-white crystalline solid in most lab environments. The chemical draws attention for its defined structure: a propanediol backbone linked at the (R)-configuration to a 3-chlorophenyl group. Years of chemical research make its formula clear—C9H11ClO2—balancing a chlorinated aromatic ring and versatile diol side-chain. In my time working with similar aromatic diols, the hand-feel of the solid, sometimes flake-like, sometimes granular, signals purity.
The core structure involves a phenyl ring substituted with chlorine at the meta position (carbon three), paired to a chiral carbon, which carries two hydroxyls at carbons one and three—a characteristic of 1,3-propanediol derivatives. For those in synthesis labs, the importance of enantiomeric purity cannot be overstated. Only the (R)-enantiomer offers specific reactivity and compatibility in downstream applications, such as pharmaceuticals or specialty polymers. CAS and HS Codes fall under typical organic intermediates, with the HS Code reflecting its role as a chemical raw material—usually under 2906, which covers phenols and phenol alcohols.
In my lab experience, this compound always appears as a free-flowing powder or as brittle flakes. Density stands around 1.3 g/cm³, a middle ground making it neither especially light nor cumbersome in large volumes. Melting points hover near 90–93°C, pointing to stability under ambient storage yet accessible for controlled melting. You rarely see (R)-1-(3-Chlorophenyl)-1,3-propanediol as a liquid unless in heated solution or under solvent. When dissolved in ethanol or DMSO, it forms clear, stable solutions, making handling and blending straightforward. In crystal form, it takes on sharp, monoclinic lines under the microscope—a feature useful for purity analysis.
Safety ranks high with compounds like this, partly due to the aromatic chlorine. Skin and eye contact bring irritation, so goggles and gloves become standard gear. On exposure, its moderate toxicity reminds me to work under a fume hood and store it away from food and skin-care compounds. Dust generation brings additional concern; fine powders can drift, so working gently and using dust masks helps limit inhalation risks. I often see material safety data sheets flagging potential harmful effects, pushing for careful labeling and sealed containers.
Industrial chemists recognize (R)-1-(3-Chlorophenyl)-1,3-propanediol as a foundation for more complex molecules. Early in my work on custom synthesis, this diol served as a building block for beta-blockers and other pharmaceuticals. Its combination of reactivity and manageable physical properties make it a go-to intermediate in chemical manufacturing. Quality raw material should appear as white, with minimal odor and little moisture. Checks for chemical purity through HPLC or NMR ensure no dangerous byproducts sneak into the next stage—an absolute must alongside stable packaging.
Chlorinated organics have a mixed record in environmental circles. Handling and disposal require attention to avoid chlorinated waste entering the waterways. Labs and factories need real plans for solvent recovery and secure chemical waste containers. Automation and green chemistry principles play valuable roles here: using safer solvents and capturing vapors cut down the long-term harm. In a time when sustainability counts for every component, clear protocols for recycling or neutralizing unused stock support both community health and responsible sourcing.
As science keeps pushing for better medicines and cleaner industrial processes, the importance of reliable starting materials remains constant. Experience shows that buyers look for transparent sourcing, full property disclosure, and proven safe handling. Maintaining robust QA checks, proper storage, and up-to-date safety training in the workplace help avoid small mistakes turning into major problems. With continued attention to purity, user protection, and environmental best practices, (R)-1-(3-Chlorophenyl)-1,3-propanediol proves its worth time and again in the evolving landscape of specialty and bulk chemical production.
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