L-(+)-THREO-2-AMINO-1-PHENYL-1,3-PROPANEDIOL stands out as a chiral amino alcohol, playing a role in organic synthesis and fine chemical production. This compound falls into a category of materials that blend an amino group with a hydroxylated carbon backbone, paired with a phenyl ring that brings stability and potential reactivity. Such molecules often show up in the development of pharmaceuticals or as essential intermediates in the creation of complex bioactive agents. The importance of chiral purity here can’t be overstated, especially in fields focusing on enantioselectivity. The L-(+)-threo configuration brings distinct implications for downstream applications, underscoring that structure and stereochemistry matter.
This compound, depending on storage and ambient conditions, takes form as either a white crystalline solid or a fine, free-flowing powder. Sometimes, production methods give rise to material in flake or pearl forms, which dissolve well in common lab solvents such as water, methanol, or ethanol. The density of L-(+)-THREO-2-AMINO-1-PHENYL-1,3-PROPANEDIOL generally remains close to 1.1-1.2 g/cm³. Such physical traits allow for easy weighing and precise dosing in controlled lab work. With a melting point often ranging from 170°C to 174°C, users do not need to worry about ambient-temperature degradation, as long-term storage seldom leads to clumping or liquefaction in dry environments. The crystalline quality supports accurate infrared and NMR analysis for those tasked with checking batch purity. These features establish reliable performance across multiple applications—whether used as a raw material, reagent, or intermediate.
The molecule follows the formula C9H13NO2, built from a three-carbon backbone sporting an amino group on the second carbon, a phenyl ring linked to the first carbon, and a hydroxyl on both the first and third carbons. This creates a structure that resembles amino alcohols seen in chiral pool synthesis. The spacing and arrangement rule out rotational symmetry, locking it into the L-(+)-threo form. Analytical chemists often point to the property of specific rotation, as this compound shows positive optical activity, a marker of its enantiomeric purity and biological significance. Molecular weight sits at 167.21 g/mol, making calculations for reaction stoichiometry straightforward in practical workflows. Each function—amino, hydroxyl, phenyl—gives the substance potential as a building block where both nucleophilicity and secondary structure have value.
L-(+)-THREO-2-AMINO-1-PHENYL-1,3-PROPANEDIOL does not fit most definitions of a volatile or acutely hazardous chemical. Many suppliers assign it a hazard classification based on minor skin or eye irritation risk, so gloves and goggles make sense during weighing and solution preparation, echoed by safety data sheets. Spills usually clean up with water and detergent; there is no evidence of significant combustion risk or reactivity under typical lab conditions. Ventilation, dust minimization, and sealed containers extend shelf life and reduce degradation. This chemical enjoys relative chemical stability, maintaining crystalline or powder form in dry containers at room temperature. If accidental ingestion or inhalation occurs, risk remains low for healthy adults, though it should be kept clear of food contact and labeled as a non-consumable raw material.
Customs and shipping departments routinely identify L-(+)-THREO-2-AMINO-1-PHENYL-1,3-PROPANEDIOL with Harmonized System (HS) Code 2922199090, which covers a range of amino-alcohol-type chemicals not classified as hazardous under most international guidelines. Users pay attention to this code for tariff, import, and customs clearance processes. Shipment of the raw material typically arrives in sealed, labeled packaging—solid, powder, or crystalline—as required by local regulations governing laboratory-grade chemicals. Regulatory bodies consult these codes to monitor import/export balances and ensure only authorized parties handle specialty fine chemicals.
Synthetic chemists favor this amino alcohol in asymmetric transformations, where it can serve as a precursor for active pharmaceutical ingredients, ligands for catalysis, or monomers in specialty material development. The chiral center is a prized property, so users employ the material in ways that guard its configuration. In my own research, finding a reliable source with consistent melting point and optical rotation values made a real difference to downstream steps. You learn quickly that molecular purity saves hours and forestalls failed reactions. For those in quality assurance, reliable density and crystalline form matter—batch consistency keeps project timelines on target and ensures compliance with pharma or fine chemical standards. The fact that the compound dissolves easily in alcohols and water allows cleaner workups, rapid filtration, and prompt transition to further synthetic steps.
Risk management counts. Safety sheets for L-(+)-THREO-2-AMINO-1-PHENYL-1,3-PROPANEDIOL list possible but mild irritation for eyes or open wounds. Realistically, exposure scenarios for lab workers rarely lead to significant harm, because fume hoods and gloves are standard practice. Unused or waste product, disposed of in solid or solution form, should follow local chemical disposal codes. Typical routes involve aqueous waste for dilute solutions, or sealed-sharps collection for crystalline remnants, avoiding exposure to municipal water or soil. These practical habits come not from fear, but from respect for personal safety and communal responsibility. Chemical education and training remove risk from the equation, letting people focus on scientific progress and new product development rather than emergency room visits.
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