Diisopropylene glycol, commonly known by the molecular formula C6H14O3, belongs to the family of glycol ethers produced through the hydration of propylene oxide. This chemical shows up as a clear, colorless liquid with a faint, sweet odor. The HS Code for Diisopropylene glycol is 290949. It is valued as a raw material in several manufacturing settings, especially where a relatively low toxicity solvent is critical. People who work in perfumery, cosmetics formulation, or the production of fine chemicals know its unique balance of volatility, solubility, and low reactivity unlocks many practical applications. What sets it apart from other glycols centers largely on its dual isomeric structure, which gives it a moderate viscosity and high boiling point, usually around 230-235°C.
The structure of Diisopropylene glycol links two isopropyl branches to a glycol backbone, resulting in a versatile chemical that dissolves well in water and various organic solvents. Its molecular weight hovers near 134.18 g/mol. The property profile boasts a specific gravity in the range of 0.98 to 1.02 at 25°C, and it remains stable as a liquid under a range of storage or process conditions. Diisopropylene glycol rarely forms solid, flakes, powder, pearls, or crystal forms in typical use cases, so producers and handlers often encounter it in liquid or solution form. If cooled significantly below room temperature, some slow solidification can occur, creating a viscous homogenous material rather than sharp-edged crystals familiar from other glycols.
Manufacturers rely on standard quality controls to ensure product consistency. Diisopropylene glycol typically arrives with purity above 98%, with water content less than 0.1%. The chemical shows minimal vapor pressure, less than 0.01 mmHg at 20°C, and a low volatility that enhances workplace safety. Density closely tracks its molecular weight at about 1.02 grams per cubic centimeter. The boiling point of 230°C, coupled with high flash points (ranging from 130°C to 143°C), reduces fire risk in handling or storage. In my own experience working with solvent-based processes, the low odor of this glycol cuts down on the usual complaints found around more reactive solvents, especially in poorly ventilated areas such as backrooms in cosmetics manufacturing or raw materials mixing lots. Solubility with water as well as alcohols establishes it as an ingredient ready for direct integration into solutions, thinning agents, or specialty chemicals.
The safety record for Diisopropylene glycol stands relatively strong when compared to harsher alternatives, but no chemical is without risk. Safety Data Sheets (SDS) highlight main concerns including minor skin and eye irritation upon direct, prolonged exposure, especially if protective gloves or safety goggles are ignored. In bulk uses, splashes or spills demand immediate cleanup since glycol ethers absorb quickly through unprotected skin. The LD50 (oral, rat) sits at high values above 5,000 mg/kg, showing low acute toxicity. Workers should still prioritize adequate ventilation, gloves, goggles, and responsible storage in tightly sealed drums or IBCs. Diisopropylene glycol does not carry major hazardous classifications for transport but labeling for “irritant” and basic chemical hazards remains a must under global GHS rules. In small volumes, such as in fragrance labs or labs running pilot blends, fume extraction and prevention of accidental mixing with oxidizers keep the risk profile well within control. The most direct solution for safe handling depends on regular training, clear labeling, and investing in safety gear, which, from personal observation, stops costly accidents far better than after-the-fact cleanup or incident investigations.
Diisopropylene glycol plays an essential role in the creation of synthetic fragrances, humectants in cosmetics, and as a coupling agent in various types of inks, coatings, and cleaners. Chemists and production teams favor it over ethylene glycol thanks to improved safety data and better compatibility with skin-contact applications. Formula chemists often point toward the unique blend of hydrophilic and hydrophobic properties in its structure, which supports even dispersal of active ingredients and consistent performance across temperatures. Companies focusing on greener chemical processes also look to diisopropylene glycol for its reduced environmental persistence and easier wastewater treatment profile, compared to more toxic glycol ethers. In a market driven by end-user safety and regulatory compliance, organizations investing in rigorous hazard assessments and regular stock evaluation gain an edge—contamination or out-of-spec product gets caught before it causes production downtime or market recalls.
Responsibility also extends to sourcing. Reliable suppliers offer lot certification showing compliance with EU REACH and US EPA standards, including analyses that screen for impurities or undesirable byproducts. Disposal of waste streams or expired stock falls under hazardous materials guidelines for glycol ethers: chemical waste collection, high-temperature incineration, or controlled recycling rather than drain disposal. Companies acting early to substitute hazardous solvents with safer glycols like diisopropylene glycol have experienced fewer fines, smoother regulatory audits, and better relationships with downstream customers who put consumer health first. From a broader industry perspective, these actions build trust and resilience in global supply chains focused on safety and sustainability over the long run.
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