(aS,S)-Amino-α-[[1-[[4-(2-pyridinyl)phenyl]methyl]hydrazino]methyl]benzenepropanol trihydrochloride belongs to a category of organic compounds that include both hydrazine and amino alcohol functional groups. Chemists pay close attention to its extended molecular structure, which combines a hydrazino moiety and a pyridinyl-substituted aromatic ring. This particular scaffold allows diverse reactivity and complexation patterns, which speaks to its versatility across chemical synthesis and pharmaceutical research. The molecular formula stands as C21H25N5O·3HCl, illustrating three hydrochloride molecules associated with every base unit. Each of these brings about a shift in solubility and stability, influencing handling and reactivity throughout the research and production pipeline. The compound’s HS Code, aligned with fine chemicals for laboratory or pharmaceutical use, typically falls under 2933.39, which covers heterocyclic compounds with nitrogen hetero-atoms.
This substance reveals itself as a solid under standard storage conditions, frequently found as a fine crystalline powder or as small, white to off-white flakes. Depending on the batch and manufacturer, the crystals may appear as irregular pearls or plates, though powder form remains common for accurate dosing and ease of blending. The material’s bulk density usually hovers around 0.6 to 0.8 grams per cubic centimeter, and the true molecular density falls nearer to 1.2 grams per cubic centimeter. The product lacks a strong odor, which is common for amino alcohols with complex nitrogen functions. The melting point can vary but typically exceeds 220°C, offering thermal stability under typical processing conditions. This trait matters for those in synthesis since a defined melting range points toward a product with fewer residual solvents or byproducts. Aqueous solutions of the trihydrochloride show high solubility, delivering a clear colorless or faintly yellow solution at lab-scale concentrations. For larger applications, the ability to form stable solutions without precipitation marks a practical advantage.
The arrangement of atoms in (aS,S)-amino-α-[[1-[[4-(2-pyridinyl)phenyl]methyl]hydrazino]methyl]benzenepropanol trihydrochloride features alternating aromatic and heterocyclic rings with pendant amino and hydrazino groups. Each reactive center promises pathways for derivatization or conjugation in medicinal chemistry, making it valuable for the synthesis of targeted molecules or biologically active compounds. The presence of multiple hydrochloride salts confers water solubility while keeping the base compound stable against atmospheric moisture and oxidative degradation. Anyone familiar with hydrazino compounds knows their capability for nucleophilic attack, so controlled storage and ventilation stay important. The pyridinyl and phenyl substitutions can steer both electronic and steric properties, lending flexibility in ligand design or catalyst exploration. Because of the compound’s ability to interact with transition metals and biomolecules, it appears as a preferred option for research in organic synthesis, coordination chemistry, and potentially in preclinical pharmaceutical testing.
Reports from laboratory workers and MSDS documentation point out that, while solid and crystalline, the dust produced during handling can cause irritation to mucous membranes and eyes, consistent with standard precautions for nitrogen-rich organic compounds. The trihydrochloride salt reduces volatility, which means it does not fume or spread as easily as some free bases, but rigorous fume extraction during weighing and transfer go a long way to keep exposure negligible. The chemical itself should not be ingested or allowed direct contact with skin, as studies show some potential for toxicity through chronic exposure. Proper nitrile gloves, splash goggles, and dedicated weighing hardware count as basic requirements; workers in scale-up or process development follow standard industry protocols for hazardous organic solids. Signage and secondary containment prove useful where spillage or dispersal may raise concerns, particularly where local waste rules demand neutralization of amino or hydrazino fragments before release.
The manufacture of (aS,S)-amino-α-[[1-[[4-(2-pyridinyl)phenyl]methyl]hydrazino]methyl]benzenepropanol trihydrochloride typically begins with sourcing benzene derivatives, hydrazine hydrate, and substituted pyridine-phenyl intermediates. Each upstream feedstock faces regulatory tracking for hazardous raw materials, as hydrazine both poses a toxic risk and presents a significant environmental challenge. Popular practice calls for off-site synthesis of hydrazine intermediates, with controlled transport to reduce exposure to the workforce and the environment. Chemical engineers look for recycle or recovery loops wherever possible, since excess reagents often carry regulatory limits for disposal or discharge. Pharmachem and academic labs keep vigilant over their chemical inventories, logging every batch for shelf life and proper waste management, keeping in line with best practices under Responsible Care programs and local environmental controls. The disposal of expired compound follows acidic or oxidative breakdown, with neutralization before entry into standard chemical waste streams.
Manufacturing quality and product purity rate high for this compound, especially with applications in research or potential fine pharmaceutical development. Analytical methods such as HPLC, NMR, and IR confirm identity and track batch-to-batch reproducibility. The presence of three hydrochloride ions creates clear reference points for titration methods as part of quality assurance. Typical product shipments include a certificate of analysis, showing assay value, melting point, water content by Karl Fischer, and elemental composition. Regulatory teams pay attention to storage requirements and specifications—dry, dark, sealed containers, room temperature below 30°C, and away from incompatible substances. Any deviation from these standards can yield byproducts or degrade the material, threatening downstream results or user safety. The HS Code facilitates customs clearance and regulatory filings, while every label features chemical hazard pictograms defined by the Globally Harmonized System.
Researchers working in the field of drug discovery welcome molecules like (aS,S)-amino-α-[[1-[[4-(2-pyridinyl)phenyl]methyl]hydrazino]methyl]benzenepropanol trihydrochloride, because it offers a multifunctional scaffold adaptable for linkage, functionalization, or serving as a building block in more advanced molecules. Its solubility and stability extend its reach from pure synthetic chemistry to biochemical assays and analytical method development. The raw material pathway, involving controlled aromatic and heterocyclic assembly, supports efforts toward sustainable practices with closed-loop systems and rigorous waste minimization. Ongoing improvements in synthesis, such as the use of continuous flow reactors or alternative solvents, continue to refine both the economic and environmental footprint for manufacturers and end-users alike. As regulations keep tightening around both raw material handling and end product purity, everyone from procurement officers to lab chemists keeps focus on compliance, stewardship, and transparent documentation throughout the compound’s entire life cycle.
Providing high-quality chemical products and logistics solutions for global trade partners.
