3(S)-(+)-(1-carbamoyl-1,1-Diphenylmethyl) pyrrolidine-L(+)-Tartrate stands out in the world of specialty chemicals. This compound brings together a diphenylmethyl carbamoyl group joined with a chiral pyrrolidine ring, then paired as a salt with L(+)-Tartrate. Such combinations often target pharmaceutical applications, especially in the area of chiral synthesis and intermediate production. In my experience working with raw materials for research and pilot-scale reactions, precise chirality, purity, and physical consistency matter a great deal, because small differences often change the outcome of a drug’s efficacy or safety profile.
The molecular formula for 3(S)-(+)-(1-carbamoyl-1,1-Diphenylmethyl) pyrrolidine-L(+)-Tartrate arrives at C24H26N2O7, demonstrating a mix of aromatic rings, nitrogen, oxygen, and a well-known chiral tartrate counterion. Structurally, you’d recognize the robustness in its aromatic bulk, which stabilizes the molecule and can influence its solubility. The compound typically presents as a solid, most often crystalline. It can range from off-white to pale-yellow flakes or powder. These textures allow for fairly straightforward weighing and transfer operations, whether you’re measuring out solid, crystalline flakes or working from a powder. Densities vary based on the degree of hydration, but expect values in the range between 1.2 and 1.3 grams per cubic centimeter at ambient conditions. Experience tells me that attention to density helps when you are handling bulk material, as consistency matters for scale-up or reaction planning.
The compound falls under hazardous materials for shipping, mainly due to its organic aromatic content, potential skin irritation risks, dust inhalation, and water solubility profiles. It’s not acutely toxic, but safe handling requires gloves, goggles, and dust masks. The material doesn’t emit strong vapors but can cause respiratory discomfort if handled as a loose powder, so fume hoods are essential in lab environments. Most safety data sheets cite the need to avoid direct eye and skin contact, and to keep the material away from oxidizers and strong acids. Disposal must adhere to local hazardous waste guidelines to limit environmental impact. As someone who’s dealt with custom synthesis orders, I stress training anyone working with such compounds on proper PPE use and spill containment protocols. You don’t want a minor lapse becoming a costly emergency, especially when you handle bulk shipments.
For any advanced chemical, purity and traceability drive both research and industrial decisions. Typical purity levels for 3(S)-(+)-(1-carbamoyl-1,1-Diphenylmethyl) pyrrolidine-L(+)-Tartrate reach 98% and above, with trace metal contents tightly controlled. Water or solvent of crystallization, if present, remains within set limits, as even slight excess moisture can change solubility or reactivity. Material specifications often detail melting point (within a 3-4°C range), visual appearance, and specific rotation—since this is a chiral compound, confirming enantiomeric excess sits front and center. The international HS Code for this building block often falls under 293339, which concerns heterocyclic compounds with nitrogen heteroatoms only. Customs-clearance procedures depend on correctly and transparently documenting this code on invoices and shipping papers. In research, sourcing from suppliers who provide validated COAs with batch-level detail helps ensure both compliance and reproducible results.
Material availability covers flakes, fine powder, and pearled crystal, each offering trade-offs in handling. Flakes and pearls reduce dust, making weighing less messy—always a plus behind the bench. Powders excel in dissolution, giving fast and even input to reaction solutions, but create inhalation hazards. Bulk shipments often arrive double-bagged in sealed high-barrier plastics inside cardboard drums, which should be stored between 2–8°C. The solid form resists clumping if kept dry and cool, but crystal bridging can occur on exposure to humid air. If the need arises for dissolved forms, custom solutions in polar solvents are sometimes available, supporting direct use in certain medicinal chemistry or process development workflows. Facilities without advanced containment systems can minimize exposure by requesting compacted or pearled forms.
Real-world applications revolve around its use as a chiral resolving agent, a building block for active pharmaceutical ingredients, and in asymmetric synthesis pathways. Pharmaceutical developers rely on the precise stereochemistry that this tartrate salt delivers, allowing the synthesis of single-enantiomer drugs. In recent years, regulatory agencies emphasize enantiopure compounds—where a mixture would otherwise risk different biological effects from each isomer. In the development stages, reference-grade materials must be available with robust analytical backing. Where I’ve seen this compound used most effectively is in multi-step syntheses where each intermediate requires both high purity and documented provenance to pass clinical or regulatory muster.
Good stewardship means using airtight containers, clear labeling, and routine stock-rotations. Material Safety Data Sheets demand regular review by both new and veteran lab personnel. Beyond basic PPE, it’s smart to keep neutralizing agents nearby and to ensure spill kits always function as intended. Disposal involves licensed chemical waste handlers, with attention to any wash solvents used in cleaning up spills. Facilities should document all entries and removals of the material to trace inventory and reduce losses from mishandling. Gloves, lab coats, and splash goggles stand as everyday gear, and space allocation in flammable or chemical-safe storage lockers beats makeshift shelving every time. It pays to remember: hazardous doesn’t mean dangerous so long as respect and training exist.
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