(2R)-1-Chloro-2-propanol offers a remarkable mix of physical and chemical properties. It falls under chlorinated alcohols, with a molecular formula of C3H7ClO and a molecular weight close to 94.54 g/mol. Its structure contains a chiral center at the second carbon, which leads to the (R) configuration. A chlorine atom bonds to the primary carbon, with a hydroxyl group connected to the second, turning it into a molecule with unique reactivity and applications. The combination of chlorine and alcohol groups gives this material a reactivity spectrum that can surprise even an experienced chemist.
In practical settings, (2R)-1-Chloro-2-propanol is seen as a clear to pale liquid, although it can solidify into a crystalline form in colder temperatures. Its density stands at around 1.17 g/cm³ at 20°C. Being reasonably soluble in water, it mixes well with many organic solvents, making it useful for both aqueous and organic phase reactions. It neither forms flakes, pearls, nor powder under standard conditions, instead staying consistent as a viscous liquid. Some labs may refer to its solidified form as crystalline, though handling always circles back to its liquid state thanks to its melting point, which barely drops below room temperature.
The carbon backbone of (2R)-1-Chloro-2-propanol is simple but powerful. The R-stereoisomer gives it a specific three-dimensional shape, a vital trait for industries where molecular orientation affects synthesis results. The hydroxyl group on the second carbon brings polarity and the ability to participate in hydrogen bonding, while the primary chloride holds promise as a leaving group—a feature exploited in organic synthesis. This combination affords (2R)-1-chloro-2-propanol an important seat in the creation of intermediates for pharmaceuticals, pesticides, and specialty chemicals.
Chemists reach for (2R)-1-Chloro-2-propanol as a starter for asymmetric synthesis and as a building block for more complex molecules. In the lab, it helps bridge transformations between alcohols and halides. Industrial producers may use it in processing medicines or agrochemicals, where the right enantiomer makes or breaks a product’s effectiveness and safety. As a raw material, it plays a part in manufacturing processes where a reactive site at the first carbon changes the course of multi-step syntheses. This isn’t just a bench-top commodity — it finds its way into large-scale production lines, filling drums or liter-sized containers based on demand.
Importers and exporters will know (2R)-1-Chloro-2-propanol by its Harmonized System (HS) Code. Most global customs platforms group it under HS Code 2905.39, which covers other halogenated derivatives of acyclic alcohols. Accurate documentation of this code smooths out shipping, storage, and regulatory compliance, avoiding paperwork headaches that can delay a shipment or hike up costs.
Direct contact with (2R)-1-Chloro-2-propanol brings about a need for personal protective gear. Skin and eye irritation risks cannot be dismissed; ingestion or inhalation demand quick medical attention. Proper ventilation and sealed containers lower exposure risk. The chemical’s moderate volatility delivers noticeable vapors, so gloves, goggles, and good airflow in workspace areas help reduce harm. Ventilated storage rooms with temperature control, away from oxidizing agents and strong bases, prevent hazardous reactions and preserve purity. As a hazardous material, compliance with the Globally Harmonized System (GHS) and local regulations keeps both workers and the environment safe. Spills call for containment and cleanup with absorbent material — never a shortcut with these chemicals.
Concern over toxicological impact is no empty warning. (2R)-1-Chloro-2-propanol is harmful if swallowed, inhaled, or absorbed through the skin, with risks of organ damage after prolonged or repeated exposure. Environmental care during disposal minimizes runoff or air release, by following local hazardous waste protocols. Employers and workers each have a role in adopting proof-tested procedures, from chemical labeling to routine training and incident reporting, maintaining a healthy respect for every bottle brought into the lab or onto the factory floor.
Product stewardship serves as both a requirement and an opportunity. Storing and transporting (2R)-1-Chloro-2-propanol in specialized containers, using spill kits and air monitoring, wraps safety into daily workflow. Companies investing in sustainable chemistry might explore derivative products with reduced hazard or greener alternatives for similar synthetic roles. Research into real-time sensor technology could spot leaks or vapors before risks escalate, while automation applies stricter dosing control in batch reactions. Small choices make big differences; single-use personal protective equipment, reliable ventilation upgrades, and commitment to regulatory compliance cut accidental exposure. Regular audits and safety drills give teams practice before disaster calls. In the broader industry, networking through safety associations and sharing case studies can raise the bar for every facility handling hazardous solvents.
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