2-[(S)-(4-chlorophenyl)(4-piperidinyloxy)methyl]-pyridine L-Tartrate, sometimes categorized under the broader family of pyridine-based compounds, brings a combination of aromatic ring stability and functional group versatility to the table. The compound integrates a chlorinated phenyl group and a heterocyclic piperidine ring tied together by an ether linkage, all anchored to a pyridine core. This core is what often intrigues chemists because of its electron-rich nature and resonance stability. The L-tartrate counterion, coming from tartaric acid, not only increases solubility in polar solvents but can affect crystal growth and the physical manifestation of the compound—whether it’s encountered as crystalline, flake, or powder.
Factories and labs handling this molecule usually source it as a raw material for further synthesis, either to build more complex pharmaceutical intermediates or to investigate its pharmacological profile. The unique combination of the piperidinyloxy and pyridine structure aligns with interests in central nervous system active research, often as a building block for developing potential drug candidates. Its reactivity and binding affinity stem from both its aromatic and basic nitrogen atoms. With tightening raw material specifications in the fine chemical industry, proper knowledge of this compound’s origin, grade, and purity can affect downstream yield and product quality.
At room temperature, 2-[(S)-(4-chlorophenyl)(4-piperidinyloxy)methyl]-pyridine L-tartrate typically appears as a crystalline, off-white solid, although the presence of small amounts of solvent or impurities can cause it to form as fine flakes or even as granular powder. In some manufacturing runs, the crystalline product exhibits a pearl-like sheen, especially after slow solvent evaporation. In contrast, fast precipitation can produce a denser, opaque solid. Its molecular formula is C22H26ClN2O6, and the formula weight hovers around 450 g/mol.
The stereochemistry of the molecule matters: the (S)-configuration at the chiral center ensures consistent biological behavior. The core holds together through a set of pi-pi interactions in the pyridine and phenyl rings, with the ether oxygen providing a little flexibility in the three-dimensional structure. If someone holds a vial or bag of the tartrate, they’ll find a free-flowing material, easier to handle than sticky oil-based intermediates and less prone to absorbing moisture than hygroscopic alkaloid salts. The density sits near 1.3 g/cm3, so a liter container can hold over a kilogram of product, maximizing storage efficiency.
Precise specs can shape how this compound gets deployed in both academic and industrial contexts. Purity typically surpasses 98%, checked by HPLC or NMR verification, with water content below 0.5% to prevent hydrolysis. The compound melts between 110°C and 120°C, and displays limited solubility in non-polar solvents but dissolves well in ethanol, methanol, and water. Its crystalline nature requires storage in airtight containers. In the event of large spills or mishandling, dust generation can occur, which makes personal protective equipment—suitable gloves, particle masks, and protective eyewear—a must.
As a raw material, 2-[(S)-(4-chlorophenyl)(4-piperidinyloxy)methyl]-pyridine L-tartrate rarely arrives in solution to end users; dry, solid forms provide more shelf stability and safer transport. Solubility in mixed solvents like ethanol/water blends supports its use in both preparative and analytical chemistry. Packing usually avoids glass jars for bulk transport to prevent shattering under impact or compression. Most industrial shipments use double-sealed polyethylene or PTFE bottle liners.
International trade classification places this compound under HS Code 293339, which covers heterocyclic compounds with nitrogen hetero-atom(s) only, specifically those with an uncondensed pyridine ring. Customs agencies and importers rely on this number to track and apply tariffs or production controls. Compliance with local chemical safety regulations—like REACH in Europe—guides documentation and safe handling, from SDS preparation through to disposal.
Handling any chlorinated aromatic compound, especially with nitrogen-containing rings, invites respect for chemical safety. Contact with skin or inhalation of fine dust may cause irritation—nothing too out-of-the-ordinary for organic lab work, but still worthy of attention. No acute hazardous decomposition products under standard conditions, but incineration may generate hydrochloric acid fumes and nitrogen oxides. Such emissions mean fume hoods or enclosed transfer hoppers feature in any serious laboratory or production-line setup. If product residue or containers need disposal, professional chemical waste processing stands as the only responsible option: land or water release risks long-term environmental harm, particularly to aquatic organisms.
Over the years, the shift from generic chemical storage to smarter labeling, barcoded tracking, and real-time stock usage alerts has cut the risk of mix-ups and accidental exposures. Chemical producers, seeing increased scrutiny from both regulators and large customers, have expanded online documentation, real-time hazard communication, and quick response to any reported adverse reactions among handlers.
My experience in research chemistry shows firsthand that managing solid organic intermediates means going beyond simple MSDS sheets. Integration of digital storage logs, ongoing update of chemical hazard libraries, and clear, honest communication between chemists, EHS staff, and shipping teams creates accountability. Manufacturers can look toward more sustainable packaging—recyclable liners, right-sized containers—to keep waste and damage down. Building redundancy into procurement and using transparent sourcing keeps projects moving, even during customs or raw material delays. Investing in analytical test kits on-site means labs confirm composition matches specs, sidestepping costly mistakes or contaminated product in pilot-scale trials.
In the end, using substances like 2-[(S)-(4-chlorophenyl)(4-piperidinyloxy)methyl]-pyridine L-tartrate responsibly demands real attention to technical details and practical lab routines. Each step from bulk receipt, in-house weighing or dilution, to end-use or recycling shapes the safe, efficient, and productive path for everyone involved—from the floor chemist up through the regulatory liaison and product manager.
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