2(3-(S)-(3-(2-(7-Chloroquinoline-2-yl)ethanyl)phenyl)-3-hydroxypropyl)benzene-2-propanol represents an advanced synthetic chemical, marked by a specialized structure and secondary alcohol group. Each molecule carries a chloroquinoline ring bound through an ethanyl bridge to a phenyl group, merged into a hydroxypropyl chain connected to a benzene core with a propanol side group. This combination delivers both aromatic and aliphatic features that alter how the compound behaves under various production, storage, and handling conditions. Specialists in chemical synthesis, medicinal chemistry, and industrial manufacturing turn to this type of molecule for its reactivity profiles and potential uses in advanced materials or pharmaceutical intermediates.
The chemical’s physical form often appears as pale yellow to off-white crystalline solid, sometimes found as a moderately sticky powder or formed into pearlescent flakes, depending on residual moisture and recrystallization processes. Its density typically falls in the 1.1 to 1.3 g/cm3 range, aligning with many medium molecular weight organics. In bulk, the substance rarely stays as a fine powder unless intensively milled, showing more stability as pressed crystals or flakes that limit atmospheric moisture absorption. People in laboratories or factories usually see this compound delivered in sealed plastic containers, frequently with desiccants to constrain the material’s tendency to clump via hydrogen bonding, especially when exposed to room air or elevated humidity. The melting point consistently reaches between 105°C and 121°C, confirming its crystalline purity, and solubility veers toward moderate in acetone, DMSO, or ethanol. In water, solubility lags far behind, which impacts safe washing procedures and storage requirements.
This substance’s structure stands out among similar intermediates. The compound’s backbone features a fused quinoline and phenyl arrangement, separated by a controlled ethanyl spacer. The formula C27H26ClNO2 illustrates a well-balanced molecular design with a single chlorine atom (from the 7-chloroquinoline), a nitrogen nestled in the quinoline, and dual hydroxyls in the propanol/phenyl axis. IUPAC category classifies it under substituted quinoline derivatives; organic chemists recognize the dense aromatic system that encourages π-stacking interactions and gives possibilities in catalysis or drug design. Every atom in the chain—even the lone chlorine—shifts the reactivity, solubility, and partition coefficient, providing industrial researchers precise targets for functional optimization. Structural isomerism doesn’t usually interfere, but vigilance in synthetic routes avoids unclear side products or stereochemical drift.
International shipping or commercial import demands correct classification codes. This material usually fits under HS Code 2933 (“Heterocyclic compounds with nitrogen hetero-atom(s) only”), reflecting its quinoline basis. Local customs officers often check for intended use, especially where regions view quinoline derivatives as dual-use precursors. Europe, North America, and Asia apply both REACH and TSCA rules, so handlers need documentation for origin, purity, safety, and environmental impact reports. Even small-scale academic use often involves risk assessments, SDS incorporation, and environmental monitoring for final waste streams.
Handling this chemical brings specific protocols. The crystalline solid readily absorbs some atmospheric moisture, not enough to trigger auto-dissolution, but it increases surface stickiness and can start to clump after several days exposed. Thermal stability holds firm up to 120°C, where monitored heating may generate phenolic and quinoline fumes, though decomposition rarely produces strong odors unless mishandled. In solution, the compound shows clear, bright yellowish hues, especially in strong polar aprotic solvents, pointing to the electronic effects inherent in the quinoline and aromatic rings. Reactivity centers—especially the hydroxy propyl component and the 7-chloro site—invite custom modification, as seen in research projects aiming for functionalized polymers, sensors, or drug analogs. Laboratories report reliable NMR and IR spectroscopic signatures, thanks to the complex but well-separated peaks. Storage in cool, dry cabinets with humidity control generally preserves the crystalline integrity for over 12 months without significant color shift or caking.
Hazard assessments warn against unchecked inhalation or skin contact. The quinoline segment places the molecule in a category where toxicological reviews remain ongoing. While not volatile under ambient temperatures, powders may produce dust if shaken during bottle transfer. Direct skin or eye exposure leads to irritation and, in rare cases, sensitization. Standard practice includes PVC or nitrile gloves, long-sleeved lab coats, and shielded goggles for transfers above 10 grams at a time. Spills should be cleaned up using damp cloths or vacuum lines fitted with HEPA filters, never swept or blown, to avoid airborne particulates. Emergency showers and eyewash stations form part of standard infrastructure for handling this kind of material. Fresh air, fume cupboard use, and labeled waste collection bags prevent accidental mishandling or environmental release. In addition, waste solvent containing this chemical must pass through chemical organic waste streams, never landfill or general sink disposal, due to persistent aromatic ring systems that resist degradation in municipal wastewater plants.
Sourcing the starting components to build up 2(3-(S)-(3-(2-(7-chloroquinoline-2-yl)ethanyl)phenyl)-3-hydroxypropyl)benzene-2-propanol often involves petroleum-derived aromatic bases, with chlorination and amination steps demanding high-purity feedstocks. Traditional synthesis uses either direct Friedel-Crafts alkylations, amide coupling with advanced base protection strategies, or metal-catalyzed couplings where air exclusion and careful temperature ramps prove essential. Academic researchers pursuing greener routes try to replace hazardous solvents and reduce heavy metal byproducts. Series of tests by industry partners in Western Europe now run solvent recovery systems at pilot scale, collecting up to 80 percent of used DMSO and acetone, which cuts overall environmental impact. As demand for high-purity quinoline derivatives rises, suppliers feel more pressure to certify their material traceability. Sustainability teams within chemical companies perform chain-of-custody reviews, audit energy profiles during production, and invest in emission abatement to cut fugitive dust and airborne organics.
The detailed physical and chemical properties described for 2(3-(S)-(3-(2-(7-chloroquinoline-2-yl)ethanyl)phenyl)-3-hydroxypropyl)benzene-2-propanol demonstrate both the opportunity and responsibility facing chemical researchers, manufacturers, and end users. Meeting technical goals means mastering storage, safety, handling, and supply chains. My years in academic and industrial labs have shown that thoughtful material stewardship—supported by accurate hazard communication, investments in green chemistry, and transparent regulatory documentation—marks the difference between high-value innovation and potential environmental or health setbacks. Anyone who works with advanced molecular intermediates gains by pushing for robust safety tools, clear labeling, and continued exploration of sustainable raw material routes, blending scientific rigor with practical care. Facts and experience underline the lesson: every step, from raw material input to careful end-of-life waste handling, matters for product performance, worker safety, and environmental impact.
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