2,2-Diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide L-(+)-tartrate stands out with its chemical and physical features that capture the attention of anyone working in research, pharmaceuticals, or chemical supply. Recognized essentially as a salt formed between the acetamide derivative and L-(+)-tartric acid, the compound brings together both stereospecific and functional properties that shape its range of applications. Having handled similar compounds in the lab, its unique crystalline appearance and specific solubility behaviors show up quickly, marking it as a substance requiring careful attention—especially for those managing both hazard control and high-purity production. Touching this material, one notices dense, sharp-edged crystalline flakes that differ notably from the finer, dustier textures of many standard powders. This difference means you have to choose storage and dispensing tools that minimize both airborne particulates and accidental spillages, a practical consideration few outside the lab ever think about.
Products containing 2,2-diphenyl derivatives crop up across pharmaceutical intermediates and advanced research assays. Its structure—anchored by the diphenylacetamide core and the stereochemically defined pyrrolidine moiety—lends it value as a raw material for synthesizing chiral molecules and custom molecules for drug development. Handling requests from industry has shown me the importance of granting customers access to detailed certificates of analysis, especially since minor changes in crystal form or tartrate content shift both purity and reaction profiles downstream. Drug developers, especially those working on enantiomerically pure compounds, rely on this reagent for selectivity and yield in chiral pools. Safety also comes into play: personal experience reminds me that when scaling up for kilo lab batches, special gloves and dust control procedures keep both product and staff safe from exposure, since the compound—like many organics—has the potential for both acute and chronic effects if mismanaged.
2,2-Diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide L-(+)-tartrate presents as solid crystalline flakes with an often-off-white glint, sometimes forming small solid pearls in high-humidity environments or after brief heating. Density hovers near 1.30 g/cm³, which you feel in the hand when pouring from wide-mouthed jars—much denser than basic sodium or potassium salts. There’s no characteristic strong odor, but prolonged exposure in a closed workspace accentuates a faint, sweetish chemical scent, signaling the need for proper ventilation. Solubility in water and polar solvents doesn’t always follow a linear pattern; pH and tartrate excess influence crystallization during recovery runs. Melting points range above 165 °C, a handy trait for those who value thermal stability but need controlled reaction conditions. Chemically, its formula C20H22N2O2·C4H6O6 highlights distinct organic and ionic elements, reinforcing its dual nature as both reagent and salt. The dual molecular composition shapes its behavior in solution and solid-state reactions, confirming what synthetic chemists notice in reaction yield variations. Storage keeps best at room temperature, in tightly sealed containers, away from humid or acidic environments given tartrate’s hygroscopic nature.
The core structure consists of a 2,2-diphenylacetamide backbone bound to a (3S)-configured pyrrolidine ring, offered as an L-(+)-tartrate salt that stabilizes its stereochemistry and improves its water compatibility. Its crystal lattice, observed under polarized light, reveals patterned striations—a hallmark of tartrate salts—in sharp contrast to amorphous reagents. For bulk and analytical buyers, detailed specifications frequently include purity above 98%, precise enantiomeric excess, and residual solvent content under 0.5%. Analytical verification often deploys NMR, HPLC, and IR spectra for identity and purity checks. From experience, feeding these specs into production logs and regulatory submissions saves headaches later if an inspector knocks on the door with questions about trace contaminants or batch reproducibility. Consistency matters: users in both research and industry want to know their next bottle will behave like the last, especially when experiments hinge on stereoisomer behavior. Anyone tapping this compound as a starting material should request impurity profiles upfront—labs with tight timelines can’t risk batch-to-batch surprises.
Most shipments show up as dense crystalline flakes or loose, flowable powder. Rare batch variations bring pearl-like solid granules or even chunky blocks. Occasionally, above-standard humidity or container mishandling transforms fine powder into compressed clumps, which dissolve back to crystal with gentle agitation and mild heating. This diversity means packagers need to consider both end use and user skill—chemically savvy customers can adjust for variance, but unskilled handlers risk incorrect measurement. Unlike many organics that offer liquid options, this compound holds its own best in solid form, occasionally as a supplied solution for rapid reaction setup. Material safety sheets list it as non-volatile and non-combustible under standard conditions, but users always need to monitor temperature, as decomposition at higher heats releases pungent organic vapors. Anyone relying on precise dosing—especially in kilo-scale synthesis—should run a pre-mass check to break down any large clumps, since accurate representation means more reproducible results and fewer costly do-overs.
The molecular formula, C24H28N2O8, shows off two distinct moieties: one part reflecting the diphenylacetamide segment, the other embracing the tartaric acid’s contribution. Moles break down into typical laboratory equivalents: at 498.5 g/mol, bulk orders require careful weighing, and solution preparation needs advanced planning for precise standardization. Molecular geometry parked under the microscope demonstrates stereo-oriented ligands, a point not lost on those trying to predict reactivity or compatibility. This structure fosters stable association in both solvent-based and dry mixes, which means less caking and a lower risk of accidental self-catalyzing side reactions that have ended more than one synthesis run abruptly in my own research. With both hydrophobic and hydrophilic regions, the molecule adapts well to different reaction systems, making it popular in diversified chemical portfolios.
With density around 1.30 g/cm³, users feel the weight difference from lighter salts or polymer-forming reagents. All-the-more reason for updated storage racks—modest shelf strain becomes apparent after months of bulk storage. When used in solution, the compound dissolves predictably, helped by gentle agitation and moderate warmth, though overzealous heating leads to caramelized edges and product losses. Solution storage in glass or high-grade polypropylene bottles protects from leaching and product loss through evaporation or moisture uptake. Bulk users—especially in pharmaceutical environments—bundle material safety reviews into routine operations, since improper solution prep risks crystallization in line filters and glassware. It’s a hands-on process: I always recommend running a preliminary solubility check, adjusting solvent ratios as real-world environments rarely reflect textbook conditions.
Handling safety starts with gloves and eye protection—anyone skipping those seems to learn the hard way, with minor skin irritation or, rarely, mild mucosal discomfort if particulates enter the air. Material safety data confirm moderate hazard: not overtly toxic, but long-term contact and inhalation add cumulative risks typical for diphenyl and tartrate derivatives. Laboratory environments control airborne dust with fume hoods and low-velocity airflow enclosures. Hazardous waste generated by expired or unused stock gets bundled with organic waste, following strict guidelines on tartrate-containing substances. Newer regulations encourage reduced environmental contamination; tighter controls on lab effluent and mandatory reporting keep both staff and their local ecosystems protected. Communication helps: honest conversations between suppliers and labs about potential hazard mitigate risk far more effectively than even the cleverest engineering controls. The combination of diphenyl and tartrate moieties means end-of-life product must avoid open landfill routes, driving most users to adopt high-temperature incineration or validated chemical neutralization sinks.
HS Code for compounds like this one—going by international customs standards—usually falls within code 2924, which targets various acyclic amides and related derivatives. Experience shipping such chemicals across borders proves the importance of matching documentation exactly: incorrect designation brings customs delays or outright rejections, disrupting both research and manufacturing plans. Regulatory filings rely on accurate chemical identification numbers, labeling with hazard, and handling codes straight from the latest GHS protocols. Raw materials sourcing remains a major concern; quality depends heavily on the purity of both the starting diphenylacetamide and the L-(+)-tartric acid. A compromised batch—containing even 0.1% wrong isomer—throws off whole production runs, meaning routine supplier vetting and third-party audits follow every bulk order placed. Sustainable sourcing practices take shape as procurement teams focus on low-impact, well-documented syntheses, weighing both local chemical regulations and global fair-trade standards.
2,2-Diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide L-(+)-tartrate shows how chemical structure, physical behavior, safety, and regulatory awareness connect in real-world labs. Its performance, from raw material through final product, builds on sound sourcing, safe handling, and clear communication along the line. I’ve seen the headaches poor documentation and careless mixing cause, and I know the uphill work required to keep both product and people protected, batch after carefully measured batch.
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