(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol stands out in the world of fine and specialty chemicals for its precise molecular characteristics and well-defined stereochemistry. This compound, known in chemical circles for its two chiral centers, is a chiral building block with significant synthetic importance. It shows up in multiple industrial settings, especially where stereoselectivity in synthesis matters most. The structure features an amino group, a benzene ring, and two hydroxyl groups, which brings a synergy of chemical reactivity and stability. Chemists who need specific enantiomeric purity often turn to it because its structural arrangement supports controlled synthesis and predictable reaction outcomes, offering advantages in pharmaceuticals and other advanced material applications.
The chemical formula for (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol is C9H13NO2, and its molecular weight calculates as 167.21 g/mol. Structurally, a benzene ring attaches to the primary carbon skeleton, with amino and hydroxyl groups in defined positions that determine both reactivity and solubility characteristics. What catches my attention about this molecule is the way these functional groups invite targeted derivatization and allow for hydrogen bonding, influencing both its solid-state behavior and how it interacts in solution. The density hits around 1.18 g/cm³, based on most analytical measurements for solid material, meaning it works well for processes demanding reliable, predictable mass-to-volume calculations.
Most batches of (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol come as colorless to off-white crystals, sometimes as fine powders or small flakes. The crystalline form gives a hint at the high purity levels expected from quality suppliers; visible impurities stand out, and any deviation in color often means a careful re-examination of storage or synthesis conditions. Material arrives dry, and it shows moderate solubility in water—enough for practical preparation of stock solutions without falling back on harsh solvents. Melting point typically sits between 90 °C and 95 °C, and grain size varies by manufacturer, with some firms offering microcrystalline pearls for easier weighing and dispersion.
Industrially, (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol serves as a prime intermediate in the synthesis of pharmaceuticals that demand optical activity. Its chiral centers allow drug makers to build molecules that fit biological targets exactly, often boosting effectiveness and reducing unwanted side effects. The compound’s predictable reactivity—with both nucleophiles and electrophiles—has made it useful in custom synthesis of beta-blockers, anticancer agents, and other valuable small molecules. Aside from pharma, it occasionally shows up in specialty research labs where enantioselective reactions remain crucial.
From my own experience handling amino alcohols in a university lab, safety takes top priority. Amino groups and phenyl rings both deserve caution: gloves protect against skin sensitization or irritation; proper venting and fume extraction stop vapors and dust from causing respiratory harm. While this compound doesn’t carry the volatile toxicity seen in some solvents, attention to storage conditions—cool, dry, and away from oxidizers—ensures long shelf life and prevents unexpected reactions. Safety data underscore the importance of keeping containers tightly closed and minimizing exposure by working under a chemical hood during transfers or solution preparation.
For customs processing and international shipping, (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol falls under the HS Code 2922.49, marking it as an amino alcohol and derivative. This classification affects how raw materials move across borders, impacting import tariffs and mandatory reporting. Health regulations and chemical registration protocols across major markets, including REACH in Europe and TSCA in North America, call for rigorous notification and documentation—both for raw compound imports and downstream products made from it. Clear labeling and accurate Certificates of Analysis support traceability and compliance in global supply chains.
On the supply side, I have seen major chemical retailers and custom synthesis firms package this material in airtight bottles or sealed foil pouches, usually in increments from grams to multi-kilogram batches. Bulk buyers—often in the pharmaceutical space—benefit from stable pricing if they source directly from contract manufacturers with integrated production lines. Underlying raw materials derive from benzaldehyde and ammonia derivatives, which anchor the availability and cost structures. Market trends suggest buyers look for suppliers with documented sustainability and process safety standards, reflecting growing end-user focus on social responsibility and regulatory reliability.
Hazard profiles for (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol generally land in the moderate range. Acute toxicity to humans remains limited when handled correctly, but as with many amino alcohols, accidental ingestion or significant exposure to dust and vapors may trigger adverse effects. Waste streams containing this compound must be neutralized and treated according to local guidelines, since amino-functional organics can disrupt wastewater treatment microbes and, at scale, impact aquatic environments. Chemical safety data sheets recommend using appropriate containment, good labeling, and prompt spill management to protect both operators and the environment. Trained staff who understand reactivity and toxicity risks play a major role in preventing accidents and maintaining workplace safety standards.
Looking forward, demand signals from advanced medicinal chemistry hint at continued strong need for pure, well-characterized (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol. New pathways that boost yield, selectivity, or environmental performance continue to attract R&D spending. Automated handling systems in labs and pilot plants lower error rates during solution preparation and weighing, freeing up skilled operators for more complex tasks. I’ve found direct supplier engagement—the chance to question chemists about production methods or material history—builds confidence for those managing sensitive synthesis steps. With traceability and reproducibility now more critical than ever, the industries relying on this raw material push for ever-tighter batch records, secure logistics, and supplier transparency as baseline requirements.
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