The chemical (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol brings together both complexity and practicality in the world of organic chemistry. This compound stands out with its unique chirality, meaning its atoms arrange in a way that reflects a specific three-dimensional structure. The structure features an amino group, a phenyl ring, and a pair of hydroxyl groups anchored on a three-carbon backbone. These features allow it to interact in distinctive ways with other molecules, making it particularly valuable in synthesis or pharmaceutical research. People in labs recognize this molecule under molecular formula C9H13NO2, ensuring quick identification in documentation or inventory.
Looking at the bench, (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol appears as either a solid crystalline powder or, depending on processing, sometimes as small flakes or pearls. It reveals a white to off-white color, and if you grab a handful (with proper gloves), the fine, dry texture feels distinct compared to coarser bulk chemicals. Laboratory reports give a melting point ranging from 110°C to 114°C, reflecting tight molecular packing. Density usually measures around 1.15 g/cm³, so it will weigh down a sample vial more than lighter organic powders. Many folks see it taking up a fair bit of space in a jar, not densely compacted like some salts. Solubility brings some surprises — it mixes well in water, opening possibilities for aqueous reactions, but also blends into polar organic solvents, which gives formulation scientists more leeway.
C9H13NO2 stands as the identifying formula for this chemical. Each molecule lays out a scaffold: a central chain of three carbons, with an amino group (-NH2) attached to the second carbon, and hydroxyl (-OH) groups branching from the first and third carbons. Take a closer look, and you see a phenyl group hanging off the first carbon, shaping the molecule's character and reactivity. There’s a long tradition of using this setup as a core piece in drug development. Safety data demands attention: while not classified as extremely hazardous in its raw form, direct skin or eye contact brings irritation, and inhaling dust may stress the lungs after prolonged exposure. Material safety sheets provide direct advice — goggles, gloves, and proper ventilation always matter in the workspace. Flammability remains low, so regular room storage works, though labeling and tracking for regulatory compliance, such as under “HS Code 2922199090,” stays necessary for shippers and importers.
Material handled as (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol brings specific purity levels — often 98% and above for use in research or synthesis. Impurities, even at tiny fractions, can derail a reaction or introduce noise into clinical results, so quality control teams use HPLC and NMR spectrometry to guarantee composition. In my years around formulation work, I have seen this chemical move between vials and bulk containers in the form of solid, sometimes even shifting through solution formats if the job benefits from easier mixing. Its strong market demand arises from its utility as a raw material in drug synthesis, mainly acting as a building block toward active pharmaceutical ingredients. Chemists count on predictable reactivity from the amino and hydroxyl groups, which accept or donate atoms during synthesis, making structural tweaks possible without messy side-products.
Those working daily with (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol know to approach with healthy respect. The material doesn’t give off noticeable odor, but its fine particles hang in the air if handled hastily, and nobody enjoys an itchy throat from stray dust. Spills clean up quickly on hard surfaces, but residues stick on porous workbenches, so proper containment matters. Repeated skin exposure may raise the risk of dermatitis, especially in people with sensitivities to amines or phenyl derivatives. Fastidious hand-washing, goggles, and disposable sleeves minimize most risks. Chemical waste streams absorbing this compound follow hazardous waste rules, indicating its potential downstream environmental concerns if released unchecked. For those buying or selling in large volume, transport by ground or sea gets logged under the Harmonized System Code, so customs officials and logistics planners need clarity on every label and manifest.
Factories producing (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol often operate continuous reactor lines, feeding in benzaldehyde and nitroethanol intermediates, while closely regulating temperatures and solvent choice to maintain optical purity. I have watched skilled operators calibrate machinery to hit the right crystalline fraction, storing the outgoing product as flakes, powders, or fine crystalline solids, depending on downstream needs. Each batch tested for melting point and purity before release matches longstanding GMP requirements. Downstream, pharmaceutical groups rely on valid certificates of analysis and traceability, reflecting an industry-wide emphasis on accountability. An open dialogue with suppliers ensures quality and safety practices extend across borders. Every incident report or batch recall teaches practical lessons — not just for regulatory compliance, but for the broader mission of protecting people’s well-being, from the scientist in the lab coat to the patient who eventually benefits from the breakthrough therapies built off this unassuming but essential material.
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