1-Propanol, 2-chloro-, (2R)- stands as a distinct chemical compound featuring a three-carbon backbone, a chlorine atom attached to the second carbon, and an (R)-stereochemistry that gives the molecule specific spatial properties. This compound finds utility as a raw material in various chemical processes and often lands on supply lists for pharmaceutical research, specialty synthesis, and agrochemical development. The chemical formula, C3H7ClO, hints at a simple yet reactive structure, presenting both an alcohol group and a halogenated carbon in a single molecule. This molecular identity shapes its behavior, influencing solubility, reactivity with acids and bases, and compatibility with organic solvents.
The structure features a primary alcohol functional group at one end, with a chlorine atom bonded to the central (second) carbon, leading to the full name 2-chloro-1-propanol. The (2R) denotes absolute configuration, reflecting how the atoms arrange in three dimensions. The presence of both hydroxyl and chlorinated groups promotes polarity and potential for hydrogen bonding but also grants an avenue for nucleophilic substitution reactions. This property finds the compound used as an intermediate in synthesizing more complex targets, clutch where stereochemistry makes an impact.
At room temperature, 1-propanol, 2-chloro-, (2R)- generally appears as a clear to pale yellow liquid, though under certain temperature and pressure conditions it may also be prepared or stored in solid or crystalline forms. The density typically falls near 1.09 g/cm³, placing it just above water, which makes handling and mixing distinctive compared to lower-density alcohols. Solubility favors polar organic solvents such as ethanol and acetone, with moderate solubility in water and diminishing solubility in strongly nonpolar solvents. Vapor pressure remains modest, which reduces losses to evaporation and assists with safe storage, but care always remains necessary to limit inhalation exposure.
Possessing both a chlorinated carbon and an alcohol group brings twin concerns for workers and handlers. Volatile organochlorines demand vigilance since they can irritate respiratory pathways and skin, while alcohol groups can promote dehydration and defatting of skin on contact. Prolonged exposure without gloves or goggles may lead to local irritation. Vapor inhalation could induce headache, dizziness, or worse with shift-long exposure in poorly ventilated spaces. Chemical spillages risk environmental harm, as organochlorine compounds can linger and travel farther than expected. Storage containers should use airtight lids, remain out of direct sunlight, and sit within well-ventilated chemical storage zones. The HS Code, which serves worldwide customs and trade tracking, most often groups it under halogenated organic compounds, aiding in shipping regulations and documentation.
In a research setting, 1-propanol, 2-chloro-, (2R)- stays relevant for making molecules where stereochemistry matters—think chiral ligands, drug precursors, and agricultural chemicals. The reactive profile lets it serve as both a leaving group in substitution reactions and as a starting scaffold for further derivatization. This saves time for chemists needing precise products without synthesizing completely from scratch. The availability in liter-sized bottles, smaller glassware, or even as a pre-mixed solution in solvent provides options to match process scale, from educational settings to full-sized plant use. Material consistency matters greatly; batch differences in melting points, purity, or optical rotation can create significant roadblocks during pharmaceutical development, where a small slip in molecular makeup can ruin test results. Obtaining well-characterized product and confirming structure and physical properties using NMR or IR spectroscopy before use becomes a necessary step.
Quality for this compound gets measured by purity (usually by gas chromatography), specific optical rotation (to confirm the (2R) configuration), water content (Karl Fischer titration), color (APHA standard, often demanding a faintly yellow or colorless reading), and density. Many buyers ask for all details on the Certificate of Analysis, so brokers and importers must keep thorough batch records. Typical specifications call for a purity above 98%, density verified by pycnometer, and storage requirements that block moisture and light.
Safer lab handling comes from clear protocols, not just safety data sheets. All users should wear gloves and goggles, and work in fume hoods whenever possible. Chemical spill kits must be close to storage sites, and waste containing halogenated compounds needs special disposal—not just routine drains or landfill. Harmful impacts come not just from large industrial releases but sometimes from careless lab disposal routines, which add up across thousands of labs worldwide. Technicians and scientists benefit from regular training on safe handling and disposal, with clear signage and responsibility for regular checks.
Moving 1-propanol, 2-chloro-, (2R)- across borders falls under specific HS Codes, usually grouped under 2905 for alcohols or more tightly under chlorinated alcohols. This classification drives transportation paperwork, customs clearance, and regulatory reporting. Tracking by HS Code simplifies packaging and labeling, prevents delays, and guarantees that all safety and excise regulations get matched up before a drum or liter bottle leaves one facility and lands at the next. Many suppliers now include batch-specific HS Codes on documentation, which speeds up movement and reduces customs hold-ups and import/export headaches.
Chiral halogenated alcohols like 1-propanol, 2-chloro-, (2R)- give researchers leverage by providing reactive, stereodefined building blocks. To work safely and sustainably, spend time on upfront planning: review the latest safety profiles and double-check specifications so the chemical fits the project goal and meets legal standards. Use closed-system dispensing where possible to cut vapor release. Invest in secure, climate-stable storage, and build relationships with reputable suppliers who provide detailed batch records and analysis. Pressure to cut costs in chemical procurement sometimes leads to shortcuts, but the consequences—either in failed syntheses or safety incidents—rarely justify the savings.
Providing high-quality chemical products and logistics solutions for global trade partners.
