1-(Dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-2-propanol hydrochloride stands as a specialty chemical anchoring various industrial and research applications. Chemically, the compound brings together a dimethylamino group connected to a propanol backbone, linked with a phenoxy group, and fitted with a hydrochloride addition. Laboratories and manufacturers use this chemical chiefly in its solid form, which ranges from white crystalline powder to pale flakes. As a hydrochloride salt, storage and handling carry lower volatility compared to its free base counterpart, offering a more stable medium for synthesis and further formulation.
The backbone features a complex organic structure: a central propanol moiety, two aromatic rings joined by an ethyl bridge, a methoxy group positioned meta on one phenyl ring, and a dimethylamino substituent attached at the primary carbon. The hydrochloride aspect results from its encounter with hydrochloric acid, creating a salt that tends to crystallize readily. This molecule carries the chemical formula C20H27NO3·HCl, underscoring its carbon-rich, nitrogen-containing framework. The mass per mole registers near 365.9 g/mol. In hands-on settings, its density hovers around 1.09 g/cm³. Water solubility remains limited but measurable; the salt form enhances its behavior in polar solvents, allowing researchers to prepare clear solutions for analytical or preparative work.
Industrially, 1-(Dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-2-propanol hydrochloride appears as a crystalline powder, flakes, or small solid pearls. Appearance typically suggests a white to off-white solid with a clean edge under magnification. Companies deliver quantities in sealed containers to limit moisture uptake or air exposure, as the hydrochloride group can attract and absorb atmospheric water. Some researchers report that freshly unpacked material displays no pronounced odor or reactivity, though direct observation of dusting might irritate mucosal tissue on accidental exposure.
Handling this chemical with care remains critical. It is not regarded as freely hazardous on the scale of industrial toxins, although its amine group, phenolic elements, and aromatic content point to potential harmfulness if misused or accidentally ingested. Technicians routinely wear gloves and goggles when working with this substance, storing it in a cool, dry place, ideally below 30°C, in well-sealed glass or HDPE containers. Risk of skin irritation, eye discomfort, or respiratory sensitivity drives the need for bench-level vigilance. Direct contact brings risk particularly for those with sensitive skin or documented allergies, while chronic exposure studies remain scarce in public literature. Facilities keep material safety data sheets (MSDS) on hand for immediate reference in the event of accidental spills, recommending water and mild detergent for surface decontamination.
On commercial invoices and in regulatory documentation, 1-(Dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-2-propanol hydrochloride typically lists under HS Code 2922199090, reflecting its status as an organic compound with basic nitrogen functionality. Raw material roots often trace back to petrochemical-derived phenyl rings, chloroethanols, and methoxybenzene intermediates, synthesized and refined through controlled batch processes in pharma or specialty chemical facilities. It rarely arrives to the end-user in a raw or impure form; manufacturers rely on multi-stage distillation, crystallization, and filtration to arrive at a substance above 98% purity, limiting exposure to potentially active impurities or volatile byproducts.
Researchers prize this molecule in medicinal chemistry, and in some cases, early-stage drug development settings use its backbone for structure-activity relationship studies, improving selectivity or bioavailability. Its ample aromatic content and moderate solubility profile sometimes suit it for physicochemical screening, offering a touchstone for partition coefficient measurements or as an intermediate standard in analysis. For advanced chemical synthesis, the compound’s phenolic oxygen often serves as a point of attachment for further modification—polymer chemists might use such handles to build more significant molecular frameworks, or as anchor points in surfactant or specialty material development.
Despite the stability of the hydrochloride salt, this chemical’s complex organic structure means inhalation or ingestion carry risk and direct, repeated skin contact risks sensitization. Storage away from acids, oxidizers, or strong alkali prolongs shelf-life and functional integrity. Users always label containers clearly and never transfer powder, flakes, or solution into vessels marked for food, water, or unrelated laboratory work. Disposal poses less risk in dilute aqueous solution than in concentrated form, though compliance with local hazardous waste legislation always comes first. Regular training for laboratory and production staff, attention to labeling, and adherence to global Harmonized System and GHS pictograms further reinforce confident, safe handling.
Bulk shipments travel in sealed polymer drums or triple-layer foil bags inside rigid containers, cushioning against physical shock or exposure. Smaller research-grade quantities often arrive vacuum-packed to reduce oxygen and humidity interaction. Receiving departments should check seals and packaging before signing off on deliveries, logging lot numbers and expiration dates for quality traceability. Warehouses provide dark, dry storage rooms, never stacked next to foodstuffs, acids, oxidizers, or flame sources. Even in non-hazardous quantities, trace spills or leaks require swift attention: sweep up dry, ventilate space, and consult chemical hygiene protocols before resuming normal operations.
Buyers of 1-(Dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-2-propanol hydrochloride demand a purity level of not less than 98%. Analytical labs employ HPLC, NMR, or FTIR to confirm identity and purity, looking for absence of major UV-active impurities. Particle size may be specified to support solubility or blending requirements. Moisture content, measured by Karl Fischer titration, should fall under 0.5% for most end-uses, as elevated humidity can promote caking or loss of flow. End-users often request certificates of analysis with each lot, covering melting point, appearance, residual solvents, and assay percent.
Expanding safe practice means more than personal protective equipment: labs and production sites benefit from automated weighing and dispensing stations, local exhaust ventilation, and pictogram-driven reminders. Commitment to documented handling, storage, and disposal protocols prevents accidents before they surface. Companies making this chemical in-house might invest in sealed reactor systems and automated filtration, minimizing handler contact and ensuring every gram stays traceable. For researchers, digital inventory tracking, environmental monitoring, and regular safety drills form the backbone of a safer, more productive workplace. Consulting with chemical safety organizations, conducting regular audits, and updating MSDS and risk assessments as more research emerges reinforces responsible stewardship across the product’s lifecycle.
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