1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol hydrochloride belongs to the family of pharmaceutical intermediates valued for its multi-functional chemical structure. Users with a background in organic synthesis encounter this compound in both research and applied chemistry work. Experience in the lab reveals the molecular formula C19H29NO•HCl, a formula reflecting its complex architecture, which merges a cyclohexyl ring, a phenyl moiety, and a substituted pyrrolidine backbone. Its molecular weight is roughly 323.9 g/mol, making it heavier than many common solvents or basic organic building blocks. The compound fits squarely within fine chemical inventories, not just as a theoretical entity but as a viable raw material, especially in multi-step synthetic processes. The presence of both polar and non-polar structural components influences its interactions and handling practices across a range of laboratory and manufacturing environments.
Chemists and technicians find that 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol hydrochloride typically appears as a solid, presenting in forms like flakes, powder, or sometimes as irregular solid lumps. The hydrochloride salt confers additional stability and solubility in aqueous media. This physical robustness becomes important in storage, transport, and weighing; material tends to maintain integrity even under varying humidity conditions. The crystal lattice, a result of the interaction between the hydrochloride ions and the base molecule, gives a faint sheen that signals purity to experienced eyes. When processed as a powder, it resists caking, provided the storage environment remains dry and free of contaminants. While many substances in this chemical class give off characteristic odors, this compound tends toward a faint, almost imperceptible scent, reducing concerns during routine handling.
As a hydrochloride, this compound’s density lands at approximately 1.16–1.22 g/cm3 depending on residual moisture and crystalline form. Melting points are typically recorded in the range of 139–143°C, which provides clear guidance for thermal processing, crystallization, and purification steps. Solubility in water and select polar organic solvents enables versatile application across chemical, pharmaceutical, and material science research. Those with hands-on experience appreciate the value of predictable dissolution behavior, especially during formulation or analytical assessments. The compound resists oxidation and reduction under ambient conditions, while the hydrochloride component suppresses base-mediated decomposition, extending shelf life and minimizing hazardous degradation products.
Safety always feels personal in the lab. 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol hydrochloride requires proper respect, as misuse or negligence zones can create health risks. Exposure to powders—either via respiration or skin contact—can produce irritation, and safety data sheets point toward the need for gloves, goggles, and adequate ventilation. Ingestion or significant exposure may cause harm, consistent with many bioactive intermediates. Thermal decomposition, though uncommon, may release hydrogen chloride and other irritants. Its solid state lessens volatility, reducing the likelihood of widespread airborne contamination. Waste containment and neutralization procedures call for standard practices with acidified organics—segregated containers, absorption materials, and professional chemical disposal. Spill cleanups, while rarely dramatic, still demand respect for personal protection and environmental guidelines.
This compound serves as a building block within advanced synthetic routes, bridging gaps between raw commodity chemicals and targeted pharmaceutical agents. Its unique profile allows for selective functionalization—chemists modify it at the pyrrolidine or cyclohexyl group, paving the way to analogs and novel compounds in the search for improved biological activity. Sourcing typically involves the reaction of cyclohexanone, phenylmagnesium bromide, and pyrrolidine-derived intermediates, followed by salt formation under hydrochloric acid. Each of these input chemicals shapes the batch-to-batch consistency. Chemical suppliers list the HS Code, most often under “pharmaceutical intermediates” or “organic chemicals not elsewhere specified,” ensuring customs classification for legal cross-border movement. The status of this material as a specialty raw ingredient influences supply chain practices, import duties, and quality assurance priorities in research, pilot-scale, and manufacturing environments alike.
Chemical users learn that good stewardship extends beyond personal safety. This hydrochloride, while not acutely hazardous in trace amounts, still demands proper control from storage through disposal. Containers must be tightly sealed, labeled with all relevant hazard information, and kept away from incompatible agents such as bases, strong oxidizers, and moisture-sensitive chemicals. Laboratories and production sites alike adapt secondary containment and shelving strategies, balancing accessibility with containment in case of accidental rupture or spillage. Where regulations require, tracking by weight and material code supports compliance and traceability. Disposal rarely presents surprises, provided residues and waste solutions are managed under protocols for acidic and potentially bioactive organics. Emphasis on best practices in training and documentation goes beyond compliance to foster a culture of mutual protection among those who handle or transport this substance.
Those with direct industry experience recognize that challenges can appear in sourcing, purity verification, or adapting to regulatory shifts. Purity thresholds impact downstream synthesis—small deviations introduce questions about batch validity or reproducibility. Quality control, including NMR and chromatographic analysis, underpins confidence in each shipment. Import regulations, changing regularly across jurisdictions, require export teams to stay up-to-date on HS codes and restricted use listings. Improvements often hinge on open communication—between researchers, safety officers, and material suppliers. Smart packaging options, better real-time tracking, and ongoing hazard training build resilience into the system. As pipelines in drug discovery or specialty formulation grow more complex, demand for well-characterized raw materials like this hydrochloride intensifies, spotlighting the need for shared responsibility and transparent supply chain auditing.
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