1,3-Propanediol 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]- belongs among specialty organics, pairing a propane backbone with a modified purine base. The name already sketches out the pairing of a three-carbon diol with a compound derived from the purine family that includes both an amino group and a chlorine atom locked into the ring. This dual nature points to its value in high-stakes research, chemical synthesis, and raw material development where specificity matters as much as purity. Chemists who work with nucleotide analogues or specialty pharmaceuticals might know this molecule for the way it bridges simple carbon chains and bioactive nucleobases. Its profile carries significance wherever structure shapes function.
Chemically, the formula reflects its hybrid character: carbon, hydrogen, nitrogen, oxygen, and chlorine come together to form a molecule with both water-loving diol features and the complexity of a chlorinated purine. The precise formula, often written as C10H16ClN5O2, shows ten carbons, sixteen hydrogens, five nitrogens, two oxygens, and one chloride sitting on the same backbone. This structure changes the way synthetic chemists think about reaction paths and applications. Under analysis, the molecular weight hovers around 289.72 g/mol. Experience in the lab can show how the arrangement of the diol impacts melting and boiling points, and how the chloro group on the purine ring alters reactivity, both for transformations and formulation.
1,3-Propanediol 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]- usually appears as a solid at room temperature. Its crystalline nature becomes apparent during extraction, where well-formed crystal shapes often signal successful isolation. Handling might reveal a product available as powder, flakes, or tiny pearls–each form reflects a different processing stage or intended application. The density for this compound, though less published than for common reagents, closely ties to its molecular packing in the solid state, generally estimated slightly above 1 g/cm³. Solubility information holds weight, as users look to dissolve it in organic solvents or water, often observing moderate to low solubility in pure water but improved uptake with warm aqueous buffers or DMSO.
Detailed specifications list purity above 98% for research and pharmaceutical work, with moisture levels controlled below 1% to preserve stability. Trace metal content and byproduct residues usually undergo strict verification. Safety shines as a key concern, not simply due to standard chemical cautions but because of the molecule's modified purine ring: inhalation or skin contact could raise allergic reactions or mild chemical burns. Its safety profile prompts labeling as hazardous under GHS management, with safety data sheets covering risks of ingestion, inhalation, and repeated exposure. While suppliers typically deliver it in sealed multi-layer bags or bottles, users should store it in cool, dry, and well-ventilated spaces to prevent degradation. Standard HS Code for customs and international shipping often stands at 29335995, falling in line with organic chlorine derivatives.
The lure of 1,3-Propanediol 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]- shows up in its value as a raw material. Its purine core anchors it within the world of modified nucleotides, essential for developing therapeutic analogues, research assays, or even select anti-viral compounds. The diol segment brings in opportunities in polymer chemistry and as a linking group in molecular engineering. I have seen it used, albeit rarely, in diagnostic research, where slight changes to molecular structure target detection or modification of natural nucleic acids. Its reactive amine and chlorinated aromatic domains open the door to selective derivatizations, and its moderate melting point (often between 170°C and 200°C based on preparation) signals thermal resilience that chemists value for downstream syntheses.
Worker safety dominates conversation as with any synthetic intermediate featuring halogen atoms attached to aromatic rings. 1,3-Propanediol 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]- qualifies as harmful if swallowed or inhaled–not acutely toxic in the dramatic sense, but enough to warrant gloves, goggles, and fume hoods for peace of mind and regulatory compliance. Accidental spills call for proper containment and decontamination procedures, as cleanup personnel can experience irritation. Long-term disposal also matters. Chemical waste streams containing organochlorines often face stricter controls due to persistence in water and soil ecosystems. Many institutions push for closed systems and on-site neutralization where possible, ensuring no hazardous residues slip into regular waste.
Approaching the production and use of this compound means thinking beyond technical datasheets. Responsible sourcing of raw materials, preferably from ISO-certified producers, limits contamination risk and supports consistency batch after batch. Frequent independent verification of product identity through NMR, MS, and HPLC checks upholds safety, supports intellectual property, and sustains downstream applications where a single impurity could compromise biological testing or drug candidate pipelines. Safe storage involves more than following protocol; it calls for regular review of expiry dates, container integrity, and appropriate secondary labeling to warn new staff about hazards. Training new chemists in the unique risks of combining halogenated aromatics with biological targets remains important for any research group or scale-up facility.
Science thrives on the reliable production and safe management of specialized intermediates like 1,3-Propanediol 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]-. Every aspect, from chemical structure to waste management, influences not only experimental results but also the broader responsibility we share toward health, safety, and the environment.
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