Product Name: Vinorelbine Tartrate USP Standard
Chemical Name: 3',4'-Didehydro-4'-deoxy-C’-norvincaleukoblastine tartrate
Recommended Use: Pharmaceutical reference material for laboratory and research applications
CAS Number: 125317-39-7
Supplier Details: Contact information for technical and emergency queries provided by manufacturer
GHS Classification: Acute toxicity (oral, dermal, inhalation); Carcinogenicity; Toxic to reproduction; Eye and skin irritant
Hazard Statements: Harmful if swallowed, in contact with skin or inhaled; May cause cancer; Suspected of damaging fertility or the unborn child
Pictograms: Skull and crossbones; Health hazard; Exclamation mark
Signal Word: Danger
Precautionary Statements: Avoid breathing dust; Use protective equipment; Wash hands thoroughly after handling; Do not eat, drink or smoke when using this product
Chemical Name: Vinorelbine tartrate
Synonyms: Navelbine tartrate
Concentration: Typically >98% by assay
Molecular Formula: C45H54N4O8•C4H6O6 (for tartrate salt)
Impurities: Specified by pharmacopeial monograph; typically present in trace amounts below 0.1%
Inhalation: Move person to fresh air promptly; seek medical attention if symptoms persist, such as coughing or shortness of breath
Skin Contact: Remove contaminated clothing; wash exposed area with soap and water; seek medical help for persistent irritation or signs of systemic toxicity
Eye Contact: Flush eyes with clean, flowing water for at least 15 minutes, keeping eyelids open; seek immediate medical care
Ingestion: Rinse mouth thoroughly; do not induce vomiting; seek medical attention without delay
Most Important Symptoms: Typical reactions include rash, nausea, breathing difficulty, central nervous system effects; delay in effects possible for cytotoxic agents
Suitable Extinguishing Media: Water spray, CO2, dry chemical, or foam to combat surrounding fire
Specific Hazards: Product decomposition may produce toxic and corrosive fumes, including nitrogen oxides, carbon monoxide, carbon dioxide
Special Protective Equipment: Firefighters require chemical-resistant gear and self-contained breathing apparatus
Advice for Firefighters: Prevent runoff from entering water supplies; use water spray to cool exposed containers
Personal Precautions: Wear gloves, goggles, and a laboratory coat; avoid direct contact or inhalation; ensure adequate ventilation
Environmental Precautions: Prevent spills from contaminating drains and water courses; notify authorities if substance enters the environment
Methods for Cleaning Up: Collect spilled material with disposable inert absorbent (like sand or earth); avoid raising dust; place in labeled container for disposal; decontaminate affected area thoroughly
Precautions for Safe Handling: Only trained personnel should handle cytotoxic substances; use local exhaust ventilation; do not eat, drink, or smoke in work area; keep containers tightly sealed
Conditions for Safe Storage: Store in a cool, dry, well-ventilated area, away from incompatible materials; protect from sunlight and moisture; restrict access to authorized personnel
Incompatibles: Avoid contact with strong oxidizers, acids, and alkalis
Engineering Controls: Work in certified chemical fume hood or biosafety cabinet
Personal Protective Equipment: Wear appropriate gloves (nitrile or similar), laboratory coat, closed footwear, safety goggles, and face shield if splashing possible
Respiratory Protection: Use NIOSH-approved respirators if airborne exposure exceeds control limits or if local ventilation is insufficient
Hygiene Measures: Wash hands and exposed skin thoroughly after handling; never attempt to pipette by mouth
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (solid material)
Melting Point: Approximately 185-195°C
Solubility: Soluble in water and methanol; sparingly soluble in dichloromethane
Molecular Weight: 1079.13 g/mol (tartrate salt form)
Partition Coefficient (log Kow): Not determined; presumed low due to high polarity
Chemical Stability: Product remains stable under standard laboratory conditions
Reactivity: Not reactive under normal circumstances
Hazardous Decomposition Products: Toxic gases such as carbon monoxide, carbon dioxide, nitrogen oxides upon combustion
Conditions to Avoid: Excess heat, moisture, incompatible chemicals;
Polymerization: Not known to occur
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Acute Toxicity: Harmful in small amounts; oral LD50 in animals <10 mg/kg
Chronic Exposure: Known carcinogen and reproductive toxin based on animal data; long-term effects may include suppression of bone marrow, nausea, neuropathy, and organ toxicity
Symptoms of Exposure: Dizziness, nausea, anemia, immune suppression, dermal irritation, respiratory distress, GI symptoms
Target Organs: Bone marrow, nervous system, gastrointestinal tract, reproductive organs
Ecotoxicity: Highly toxic to aquatic organisms in low concentrations
Persistence and Degradability: Not readily biodegradable; risk of long-term persistence in water systems
Bioaccumulation Potential: Low, but potential for toxic effects at trace levels
Movement in Environment: Can contaminate soil and water; avoid release to the environment
Waste Disposal Method: Dispose as hazardous pharmaceutical waste through licensed chemical disposal vendor; never dispose of via household drains or municipal waste
Product/Packaging Disposal: Both contents and container require treatment as hazardous waste; decontaminate packaging before recycling if possible
Regulations: Adhere to local, regional, and national regulations regarding cytotoxic drugs and laboratory hazardous waste
UN Number: UN2811 (for toxic solids, organic, n.o.s.)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Vinorelbine tartrate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant; avoid unintentional release
Special Precautions: Carriage by authorized persons only; emergency response documents required
TSCA: Not listed; for research use only
OSHA Hazardous Chemical: Classified as hazardous; handled in compliance with laboratory safety standards
SARA Title III: Not listed as an extremely hazardous substance; requires reporting for release in certain jurisdictions
EU Regulation: Substance within REACH restrictions for laboratory use; not approved as a marketed drug substance
Other Regulatory Status: Subject to handling and use restrictions under cytotoxic agent protocols; regular safety audits and documentation required for compliance
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