Product Name: Vinorelbine tartrate
Chemical Family: Vinca alkaloid; antineoplastic agent
CAS Number: 125317-39-7
Synonyms: Navelbine tartrate; 5'-noranhydrovinblastine tartrate
Recommended Use: Chemotherapeutic drug for cancer treatment
Manufacturer: Pharmaceutical suppliers or drug manufacturers
Emergency Contact Number: Local Poison Control Center
Health Hazards: May cause severe irritation to skin, eyes, and respiratory tract. Toxic by ingestion, inhalation, and dermal exposure. Can cause bone marrow suppression and neurotoxic effects.
Signal Word: Danger
GHS Classification: Acute toxicity (oral, dermal, inhalation) - Category 2; carcinogenicity - Category 2; reproductive toxicity - Category 2; specific target organ toxicity - repeated exposure - Category 2
Label Elements: Toxic, hazardous to health, environmental toxicity
Hazard Statements: Fatal in contact with skin or if swallowed. Causes damage to organs through prolonged or repeated exposure. Suspected of causing cancer.
Chemical Name: Vinorelbine tartrate
CAS Number: 125317-39-7
Concentration: 100% (pure substance) or as supplied in pharmaceutical formulations
Molecular Formula: C45H54N4O8·C4H6O6
Impurities and Stabilizing Additives: No known significant impurities affecting classification under current regulations
Inhalation: Move to fresh air at once. Give oxygen or artificial respiration if needed. Seek medical attention without delay. Avoid direct contact with patient if possible.
Skin Contact: Remove contaminated clothing. Wash affected area with soap and plenty of water for at least 15 minutes. Seek immediate medical attention.
Eye Contact: Rinse eyes with flowing water for at least 15 minutes, lifting eyelids. Get immediate medical attention.
Ingestion: Seek medical help right away. Do not induce vomiting unless advised by a poison center or physician. Rinse mouth thoroughly with water.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam
Unsuitable Extinguishing Media: Avoid strong water jets as they may spread the substance
Specific Hazards: Produces toxic fumes including nitrogen oxides and carbon monoxide under fire conditions
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear. Avoid inhaling combustion products.
Special Precautions: Runoff from fire control may cause pollution and toxicity to aquatic life. Contain and do not let water sources become contaminated.
Personal Precautions: Use personal protective equipment including gloves, gown, and respiratory protection. Avoid breathing dust or mist.
Environmental Precautions: Do not allow release into sewers, surface water or soil. Prevent spillage from spreading.
Methods for Cleaning Up: Collect spilled material with absorbent designed for hazardous drugs. Sweep up and place in a clearly labeled hazardous waste container. Ventilate area and wash spill site with water and detergent after material pick-up.
Handling: Handle in a certified chemical fume hood or biological cabinet. Use only with trained personnel. Avoid all contact with skin, eyes, and clothing. Strictly avoid inhalation or ingestion.
Storage: Store in a cool, dry place. Keep container tightly closed and marked as cytotoxic. Protect from light and moisture. Isolate from incompatible substances including strong oxidizers and acids.
Engineering Controls: Use local exhaust ventilation and chemical safety cabinets.
Eye/Face Protection: Wear chemical safety goggles and a face shield as needed.
Skin Protection: Wear impervious gloves (nitrile or neoprene) and a protective lab coat or gown design for chemotherapy agents.
Respiratory Protection: Use NIOSH-approved particulate respirator if dust or aerosols are generated.
Hygiene Measures: Wash hands and face thoroughly after handling. Do not eat, drink, or smoke in storage or work area.
Exposure Limit Values: No occupational exposure limits established, follow safe-handling guidelines for cytotoxic drugs.
Appearance: White or pale yellow powder
Odor: Odorless or faint odor
pH: Not available
Melting Point: Not established
Boiling Point: Not established
Solubility: Slightly soluble in water, soluble in methanol and ethanol
Vapor Pressure: Not available
Density: Not available
Partition Coefficient (n-octanol/water): Not available
Flash Point: Not applicable
Explosive Properties: Not considered explosive
Other Data: Decomposes at high temperatures with toxic vapors.
Chemical Stability: Stable under recommended storage and handling conditions
Possible Hazardous Reactions: No dangerous reactions identified under normal use.
Conditions to Avoid: Exposure to light, moisture, and high temperatures
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, other toxic vapors
Acute Toxicity: Extremely toxic substance; LD50 (oral, rat) data not publicly established; reports show significant toxicity at low doses
Chronic Toxicity: Prolonged exposure leads to severe bone marrow suppression, neurotoxicity, and possible reproductive toxicity
Carcinogenicity: Suspected human carcinogen
Mutagenicity: Shown mutagenic in some in vitro studies
Routes of Exposure: Inhalation, ingestion, dermal contact, injection
Target Organs: Bone marrow, nervous system, gastrointestinal tract
Symptoms of Exposure: Nausea, vomiting, constipation, muscle weakness, numbness, immune suppression, infection risk
Ecotoxicity: Highly toxic to aquatic organisms, may cause long-term damage in aquatic environments
Persistence and Degradability: Not readily biodegradable
Bioaccumulation Potential: Not expected to accumulate, but data is lacking
Mobility in Soil: Data not available
Other Adverse Effects: One cytostatic drug molecule may negatively affect water-treatment environments and non-target species
Waste Treatment Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber.
Product Disposal: Treat as hazardous chemical waste. Place in closed, labeled containers.
Contaminated Packaging: Dispose of as hazardous waste according to local regulations.
Sewage Disposal: Do not generate waste streams containing cytotoxic drugs into drains or sewers.
Precautions: Professional waste handlers should use proper personal protective equipment and procedures.
UN Number: Not classified for transport under UN regulations, but treat as hazardous medicament.
Transport Hazard Class: Not specifically assigned; typically shipped as a regulated pharmaceutical product
Packing Group: Not assigned
Special Precautions for User: Secure container, avoid spillage or breakage. Inform carriers about hazardous properties.
Marine Pollutant: Not classified, but poses risk to aquatic life if released.
Safety, Health and Environmental Regulations: Subject to specific workplace cytotoxic drug handling guidelines. OSHA, NIOSH, and ASHP provide relevant best-practices for antineoplastic drugs.
Inventory Status: Not listed specifically by TSCA or REACH; treat as a prescription hazardous medicine.
Labeling: Follow cytotoxic hazard labeling requirements as per national or local law.
Other Regulations: Handle with care in accordance with federal, state, and local workplace safety laws. Medical surveillance of workers handling this drug is strongly advised.
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