Product Name: Vinorelbine ditartrate salt
Chemical Family: Antineoplastic agent
Molecular Formula: C45H54N4O8 · C4H6O6
CAS Number: 125317-39-7
Synonyms: 5′-Noranhydrovinblastine ditartrate
Intended Use: Research, pharmaceutical development
Supplier Information: Manufacturer details including address and emergency phone number
GHS Classification: Acute toxicity (oral, dermal, inhalation), carcinogen, germ cell mutagen, reproductive toxicity
GHS Label Elements: Skull and crossbones, health hazard symbol
Hazard Statements: Toxic if swallowed or inhaled, causes damage to organs, may cause cancer, risk of adverse reproductive effects
Precautionary Statements: Avoid breathing dust, wear protective equipment, wash thoroughly after handling
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Health Effects: Nausea, vomiting, fatigue, potential bone marrow suppression
Chronic Health Effects: Cancer risk, reproductive harm, organ toxicity (liver, nervous system)
Chemical Name: Vinorelbine ditartrate
Concentration: 100%
CAS Number: 125317-39-7
Impurities: Not applicable for pure substance
Other Ingredients: No preservatives, stabilizers, or solvents listed
Eye Contact: Rinse cautiously with water for at least 15 minutes, hold eyelids apart, seek immediate medical attention
Skin Contact: Remove contaminated clothing, wash exposed area with soap and water, seek medical advice if irritation or symptoms appear
Inhalation: Move person to fresh air, keep comfortable for breathing, obtain medical help promptly
Ingestion: Rinse mouth, do not induce vomiting, seek emergency medical attention
Key Symptoms: Severe irritation, headaches, dizziness, gastrointestinal distress, possible myelosuppression
Immediate Medical Attention Needed:** Accidental overdose or exposure
Suitable Extinguishing Media: Dry chemical, water spray, foam, or carbon dioxide
Specific Hazards: Emits toxic fumes such as carbon monoxide, nitrogen oxides on combustion
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Special Procedures: Evacuate area, stay upwind, prevent runoff from entering water supplies
Personal Precautions: Evacuate unnecessary people, wear gloves, goggles, lab coat, and NIOSH-approved respirator
Environmental Precautions: Avoid discharge into drains, waterways, and soil
Cleanup Methods: Absorb spill with inert material (sand or earth), collect in closed container, ventilate area, wash spill site after material pick up
Disposal: Dispose of as hazardous pharmaceutical waste as per regulations
Handling: Work in biosafety cabinet or fume hood, minimize dust, avoid direct contact through gloves and goggles, practice good hygiene, do not eat or drink when handling
Storage: Store in tightly closed container in a cool, dry, well-ventilated location, protected from light
Incompatible substances: Strong oxidizers, acids, alkalis
Special Storage Conditions: Locked area recommended for controlled pharmaceuticals
Occupational Exposure Limits: No established OSHA or ACGIH limit, handle as hazardous drug
Engineering Controls: Use containment devices, local exhaust, and HEPA filtration for all operations
Personal Protective Equipment: Chemically resistant gloves (nitrile recommended), lab coat, eye protection, NIOSH respirator when risk of aerosolization
Hygiene Measures: Wash hands after handling, avoid touching face, decontaminate surfaces after any procedure
Appearance: White to off-white crystalline powder
Odor: None
pH: Data not available
Melting Point/Range: 218-222°C (decomposition may occur)
Solubility: Soluble in water, practically insoluble in chloroform, ether
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not available
Partition Coefficient: LogP data not available for this salt form
Vapor Density: Not applicable
Other properties: Hygroscopic, may form dust in powder form
Chemical Stability: Stable under recommended storage and handling
Decomposition Products: Carbon oxides, nitrogen oxides on thermal decomposition
Conditions to Avoid: Exposure to moisture, excessive heat
Incompatible Materials: Strong acids, bases, and oxidizing agents
Polymerization: Not expected to occur
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Acute Toxicity: Oral LD50 in animals: 30-40 mg/kg (mouse, rat) (literature values)
Chronic Effects: Repeated exposure can cause cumulative toxic effects, bone marrow suppression, reproductive and developmental toxicity, possible genotoxicity
Carcinogenicity: Classified as a possible human carcinogen based on structure and mechanism
Signs and Symptoms: Diarrhea, vomiting, hair loss, local skin or mucosal irritation, nervous system effects, lowered blood counts
Target Organs: Bone marrow, liver, nervous system
Aquatic Toxicity: Potential toxicity to aquatic organisms, avoid direct release to waterways
Persistence and Degradability: Limited environmental degradation, moderate persistence expected
Bioaccumulative Potential: No significant bioaccumulation data available for this salt
Mobility in Soil: Expected to have low mobility, binds strongly to organic matter
Special Precautions: Dispose using licensed hazardous waste contractor to prevent contamination
Waste Treatment Methods: Incinerate at approved chemical waste facility
Disposal of Containers: Triple rinse before disposal, treat as cytotoxic hazardous waste
Contaminated Packaging: Clean thoroughly and follow hazardous disposal guidelines
Legal Regulations: Comply with local, regional, and national hazardous waste management requirements
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Vinorelbine ditartrate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labeling Requirements: Toxic, regulated for international and domestic shipment
Special Precautions for Transport: Keep isolated from food and feed, secure packaging, clearly label for hazard recognition
TSCA Status: Not listed for commercial use, research only
WHMIS Classification: Class D2A (Very toxic), D2B (Toxic)
SARA Title III: Not subject to Section 313 reporting
Regulatory Lists: Check local regulations for handling and use for hazardous drugs
Special Labeling: Pharmaceutical agent, restricted for professional and regulated use
Controlled Substance Classification: Not a scheduled drug but tightly regulated due to cytotoxicity
REACH Information: Not pre-registered in the European Union for large scale use
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