Product Name: Vinflunine Tartrate
Synonyms: 20’,20’-Difluoro-3’,4’-dihydro-vinca alkaloid tartrate
Chemical Formula: C45H54F2N4O8 – C4H6O6
CAS Number: 162635-04-3
Manufacturer: [Company Name]
Recommended Use: Pharmaceutical chemotherapy agent, cytotoxic
Contact Information: [Street Address, City, Country, Emergency Phone Number]
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) – Category 2; Carcinogenicity – Category 2; Eye Irritation – Category 2A; Skin Sensitizer – Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin or if inhaled; Suspected of causing cancer; Causes serious eye irritation; May cause an allergic skin reaction
Precautionary Statements: Avoid breathing dust or fumes; Wear protective gloves/protective clothing/eye protection/face protection; Wash hands thoroughly after handling; Use in well-ventilated area; Keep away from food and drink
Potential Acute Health Effects: Risk of systemic toxicity upon ingestion, inhalation, or skin contact; may cause nausea, vomiting, mucous membrane irritation, and central nervous system effects
Potential Chronic Health Effects: Possible carcinogen, mutagenic concerns, reproductive effects
Active Ingredient: Vinflunine Tartrate
Concentration: >95%
Impurities: Vinorelbine, other vinca alkaloids (trace); tartaric acid
Molecular Weight: 1079.2 g/mol
Other Additives: Not typically present in pure substance
Physical State: Solid, crystalline powder
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek immediate medical advice
Skin Contact: Remove contaminated clothing; wash skin thoroughly with water and soap; seek medical attention if symptoms persist
Inhalation: Move person to fresh air and keep comfortable; if breathing is difficult, provide oxygen; seek immediate medical attention
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical assistance
Most Important Symptoms: Nausea, dizziness, difficulty breathing, skin irritation, redness or rash, central nervous system effects
Medical Notes: Anticipate risk for myelosuppression and neuropathy; symptomatic and supportive care recommended
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide, or water spray for small fires; avoid strong jet of water as it can spread powder
Specific Fire Hazards: Toxic, irritating fumes and gases may form during combustion (hydrogen fluoride, nitrogen oxides, carbon oxides)
Protective Equipment: Firefighters wear self-contained breathing apparatus and full chemical-protective clothing
Special Procedures: Move containers away from fire area if safe; avoid inhalation of smoke and combustion products
Combustion Products: Decomposition may release fluorine compounds, carbon monoxide/dioxide, and nitrogen oxides
Personal Precautions: Keep unprotected personnel away; ensure adequate ventilation; avoid dust formation; wear full protective equipment including gloves and respirators
Environmental Precautions: Prevent entry into sewers, soil, or waterways; inform authorities if environmental contamination occurs
Spill Cleanup Methods: Use damp disposable towels to pick up powder, avoid dry sweeping; place in a closed container for proper disposal; ventilate area; wash spill surface with detergent and water
Disposal of Clean-up Materials: Treat wipe and wash remnants as hazardous waste
Safe Handling: Use only in biosafety cabinet or well-ventilated area; avoid skin and eye contact; avoid ingestion or inhalation; do not eat, drink, or smoke during use
Storage Conditions: Store in original, sealed container at 2–8°C (refrigerated) away from light; protect from moisture and heat sources
Incompatible Materials: Strong oxidizers, acids and bases; avoid contact with food and drink
Specific Storage Measures: Restrict access to authorized personnel only; label storage clearly with hazardous nature of contents
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing
Occupational Exposure Limits: No established OSHA/ACGIH limits; control exposure to as low as reasonably achievable
Respiratory Protection: Use NIOSH-approved respirator for potentially airborne powder or aerosols
Eye Protection: Chemical safety goggles
Hand Protection: Impermeable latex, nitrile, or neoprene gloves
Skin Protection: Lab coats, coveralls, closed-toe shoes; avoid skin exposure
Engineering Controls: Biosafety cabinet, fume hood, local exhaust ventilation
Environmental Controls: Do not permit uncontrolled release to the environment; use sealed waste containers
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (solution): Acidic, typically around pH 3–4 when dissolved
Melting Point: Around 238–240°C
Boiling Point: Not applicable (decomposes prior to boiling)
Solubility: Freely soluble in water, methanol; slight solubility in ethanol
Flash Point: Not flammable as a solid
Vapor Pressure: Not significant at room temperature
Partition Coefficient (log P): Low, hydrophilic
Relative Density: ~1.35 g/cm³
Viscosity: Not applicable
Explosive Properties: No data available; not expected to be explosive
Chemical Stability: Stable under recommended storage conditions
Polymerization: Not expected to occur
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Incompatibilities: Strong oxidizing agents, acids, alkalies
Decomposition Products: At high temperatures, releases hazardous gases such as hydrogen fluoride, carbon oxides, nitrogen oxides
Reactivity: Unstable with incompatible materials, otherwise chemically stable
Routes of Exposure: Inhalation, ingestion, skin absorption, eye exposure
Acute Toxicity: Very toxic by all routes; LD50 (oral, rat) ~10 mg/kg
Chronic Toxicity: Can cause bone marrow depression, neuropathy, liver and kidney toxicity with chronic exposure
Carcinogenicity: Animal studies suggest potential carcinogenic risk
Mutagenicity: Evidence for mutagenic effects in microbial assays
Reproductive Toxicity: Embryotoxic and fetotoxic in animal studies
Sensitization: Can cause skin and respiratory sensitization in susceptible individuals
Symptoms of Exposure: Nausea, vomiting, dizziness, skin and eye irritation, neuropathy, blood disorders
Ecotoxicity: Toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Slowly biodegradable; expected to persist in water and soil
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: Mobile in water; risk of groundwater contamination
Environmental Notes: Avoid unintentional release; hazardous to fish and other aquatic organisms, threaten local ecosystems
Waste Disposal Methods: Treat as hazardous pharmaceutical waste; incinerate at licensed facility; follow all local, regional, national, and international regulations
Contaminated Packaging: Triple rinse before disposal; treat all packaging as hazardous
Precautionary Disposal: Do not flush into drains or water sources; segregate from general waste streams
Special Disposal Methods: Coordinate collection through hazardous waste handler experienced with cytotoxic and chemotherapy agents
UN Number: UN 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Vinflunine Tartrate)
Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Yes
Transport Labels: Toxic substance label; Marine pollutant if shipped by sea
Special Precautions: Handle only by trained, authorized personnel; emergency procedures in place for spills or exposure; keep containers tightly closed and upright during transit
U.S. Regulations: Subject to OSHA hazard communication regulations; covered by TSCA for research and development use; no established permissible exposure limit
Canada WHMIS Classification: D1A (Very toxic material), D2A (Carcinogen)
EU Classification: Toxic (T), Carcinogen Category 2, Sensitizer
Symbol: Skull and Crossbones; Exclamation Mark; Health Hazard
Risk Phrases: R23/24/25 – Toxic by inhalation, in contact with skin, and if swallowed; R36/37/38 – Irritating to eyes, respiratory system, and skin
Safety Phrases: S36/37/39 – Wear suitable protective clothing, gloves, and eye/face protection
Other Local Requirements: Observe national and regional regulations for cytotoxic substances
Providing high-quality chemical products and logistics solutions for global trade partners.
