Product Name: Vinflunine Ditartrate
Chemical Name: (R)-3',4'-dihydroxy-5'-fluoro-2',2'-dimethoxy-20-oxa-4,6,15,21-tetraazadocosa-3,8,12,14,18,20-hexene-1,9,11,13,17,19,22-heptone ditartrate
Synonyms: N/A
Recommended Use: Pharmaceutical intermediate, Anti-cancer agent
Supplier Details: Pharmaceutical manufacturer, Research laboratories handling oncology drugs
Emergency Contact: Company emergency hotline, Local emergency services
GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Specific target organ toxicity, Carcinogenic hazard, Mutagenic hazard
Label Elements: Danger, Skull and Crossbones, Health Specific Hazard pictograms
Signal Word: Danger
Hazard Statements: Toxic if swallowed, May cause genetic defects, Causes damage to organs through prolonged or repeated exposure, May cause cancer
Precautionary Statements: Use only in well-ventilated area, Wear respiratory and dermal protection, Avoid release to environment, Do not inhale dust or aerosol
Chemical Name: Vinflunine Ditartrate
CAS Number: 162652-95-1
EC Number: Not available
Concentration: 100% (as supplied in research or pharmaceutical formulation)
Impurities and Additives: None reported in high-grade formulations
Inhalation: Immediately remove person to fresh air, Maintain open airway, Seek medical attention if symptoms persist
Skin Contact: Take off contaminated clothing, Wash skin thoroughly with soap and water, Seek medical assistance for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, Remove contact lenses if present and easy to do, Continue rinsing, Obtain medical attention
Ingestion: Rinse mouth, Do NOT induce vomiting, Never give anything by mouth to an unconscious person, Get immediate medical help
Medical Advice: Show safety data sheet to the medical provider, Symptoms may be delayed
Suitable Extinguishing Media: Dry chemical, Carbon dioxide, Water spray, Foam
Unsuitable Extinguishing Media: Direct water jet may spread material
Specific Hazards: Toxic fumes, Carbon oxides, Nitrogen oxides, Hydrogen fluoride may form under fire
Protective Equipment: Wear self-contained breathing apparatus, Full protective gear for skin and eyes
Special Procedures: Avoid runoff to sewers or waterways, Use firefighting measures suitable for surrounding materials
Personal Precautions: Restrict access, Wear chemical splash goggles, gloves, lab coat, respirator
Environmental Precautions: Prevent entry into drains and watercourses, Avoid ground contamination
Cleanup Methods: Ventilate area, Absorb with inert dry material, Use dedicated equipment, Collect and dispose in appropriate waste containers, Decontaminate area with approved agent
Handling: Operate in chemical fume hood or biological safety cabinet, Avoid contact with skin, eyes, and clothing, Do not breathe dust, Use tools to handle material
Storage Conditions: Store locked up, Isolate from incompatible substances (acids, bases, oxidizers), Store in tightly closed container, Controlled room temperature, Protect from light and moisture
Incompatibilities: Strong oxidizing agents, Strong acids and bases
Engineering Controls: Laboratory fume hood, Enclosed process systems, Local exhaust ventilation
Personal Protective Equipment: Nitrile or latex gloves, Non-permeable laboratory coats, Chemical splash goggles, Approved respirator for dusts/aerosols
Hygiene Measures: Prohibit eating and drinking in work area, Wash hands and face after handling, Remove contaminated clothing and wash before reuse
Exposure Limits: No occupational exposure limits established, Use lowest feasible exposure levels
Appearance: White to off-white crystalline powder
Odor: Odorless or slight odor
pH: Data not available
Melting Point: Decomposes before melting
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water and DMSO, slightly soluble in ethanol
Partition Coefficient (log P): Not available
Vapor Pressure: Negligible at room temperature
Other Data: Stable under recommended storage, Light-sensitive
Chemical Stability: Stable under normal conditions, Decomposes under heat, moisture, light exposure
Reactivity: Reacts with oxidizing agents, Strong acids and bases
Decomposition Products: May release toxic fumes under combustion, Carbon oxides, Hydrogen fluoride, Nitrogen oxides
Polymerization: Not expected to occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Harmful or fatal if swallowed, inhaled, or absorbed through skin
Chronic Effects: Risk of cancer, genetic defects, organ toxicity with prolonged exposure, Bone marrow suppression, Peripheral neuropathy
Symptoms: Nausea, vomiting, diarrhea, muscle weakness, abdominal pain, respiratory difficulties
Sensitization: Potential skin sensitizer
Carcinogenicity: Classified as potentially carcinogenic based on analogs
Mutagenicity: Evidence of mutagenic potential in in vitro assays
Reproductive Toxicity: Animal studies suggest potential for reproductive harm
Ecotoxicity: Highly toxic to aquatic organisms, Long-lasting effects in water environments
Persistence and Degradability: Expected to degrade slowly, Persistent in sediment and water
Bioaccumulative Potential: Low to moderate potential based on structure, May concentrate in aquatic species
Mobility in Soil: Limited mobility, moderate absorption to soil particles
Other Adverse Effects: Harmful to sewage treatment processes, Avoid environmental release
Waste Disposal: Dispose as hazardous pharmaceutical waste through licensed chemical disposal contractor, Do not dispose via sink or landfill
Container Disposal: Triple rinse empty containers, Treat rinsate as hazardous, Label and destroy as per hazardous waste policy
Contaminated Packaging: Handle as hazardous waste, Do not reuse containers
Regulatory Waste Codes: Assign based on local, state, and national requirements
UN Number: Not classified for transport but treat as hazardous drug
Transport Hazard Class: Toxic substance as per local regulation
Packing Group: As per country-specific guidelines
Environmental Hazards: Marine pollutant, avoid uncontained transport
Special Precautions: Ship in certified packaging, Inform carrier of hazardous status, Minimize handling during transit
Regulation Status: Controlled under international pharmaceutical laws and workplace hazard regulations
OSHA Status: Hazardous chemical as defined by OSHA Hazard Communication Standard
WHMIS Classification: D1A (Very Toxic Material), D2A (Carcinogenic), D2B (Other Toxic Effects)
SARA Title III: Not listed as specific hazard, Report under general toxic chemical inventories
Other: Subject to waste and environmental controls under national and international law, Workers must be properly trained on handling cytotoxic agents
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