Material Safety Data Sheet - Vindoline Tartrate

Identification

Product Name: Vindoline Tartrate
Chemical Formula: C25H32N2O6•C4H6O6
CAS Number: 30486-56-1
Synonyms: Vindoline Hydrogen Tartrate, Dihydroindole Tartrate Salt
Recommended Use: Laboratory chemical, research and development
Supplier/Manufacturer: Obtain exact manufacturer or supplier information from the purchase source, as traceability remains crucial in case of spill or exposure.
Emergency Contact: Refer to local country’s emergency chemical response, such as CHEMTREC or similar local services.

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal), Eye irritation, Skin irritation, Target organ toxicity
Signal Word: Warning
Hazards: May cause skin and eye irritation. Harmful if swallowed or inhaled. Prolonged contact can trigger allergic reactions in sensitive individuals. No reliable data suggest carcinogenicity, but toxic effects warrant standard precautions.
Precautionary Statements: Avoid contact with skin, eyes, and clothing. Avoid inhaling dust or powder. Use only with adequate ventilation. Wash hands thoroughly after handling. Do not eat, drink, or smoke while using this product.

Composition / Information on Ingredients

Chemical Name: Vindoline Tartrate
Concentration: 100% pure (unless mixed by supplier; check label or batch documentation for any noted impurities)
CAS Number: 30486-56-1
Impurities/Additives: No significant impurities have been documented in standard-grade product. Pharmaceutical or research-grade material generally lists minimal contaminants below thresholds that could impact safety.

First Aid Measures

Inhalation: Remove individual to fresh air, monitor for breathing distress, seek medical attention if symptoms persist. If breathing stops, perform artificial respiration.
Skin Contact: Remove any contaminated clothing, rinse affected area thoroughly with soap and plenty of water. Seek medical advice for persistent irritation.
Eye Contact: Flush eyes with gentle running water for at least 15 minutes, blink frequently, seek medical care if irritation continues.
Ingestion: Rinse mouth with water without inducing vomiting, call a physician or poison center immediately. Never administer anything by mouth to an unconscious person.
Indications of Medical Attention: Seek medical care in any case of accidental ingestion, inhalation of substantial quantities, or significant exposure to eyes or skin. Symptoms to look out for include persistent skin rashes, difficulty breathing, and swelling.

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, carbon dioxide, water spray, or appropriate foam. Avoid high pressure water streams that may disperse powder.
Specific Hazards: Combustion releases toxic fumes including nitrogen oxides, carbon oxides, and possibly other hazardous organics. Dust may create explosive mixtures with air.
Personal Protection: Firefighters should wear protective gear, including self-contained breathing apparatus, chemical-resistant gloves, and goggles.
Other Recommendations: Avoid inhaling smoke, move containers from fire area if safe to do so, control runoff to prevent environmental contamination.

Accidental Release Measures

Personal Precautions: Don chemical-resistant gloves, laboratory coat, safety goggles, and respiratory protection if dust risk is present.
Environmental Precautions: Prevent powder from entering drains, water supplies, and soils.
Methods for Clean-up: Sweep up material gently to minimize dust, place in sealed chemical waste containers for proper disposal. Ventilate the area after cleanup. Wash spill area with plenty of water to ensure all residues are removed.

Handling and Storage

Handling: Always use within properly ventilated environments, use closed handling systems if possible to limit airborne particles. Avoid sources of heat, static electricity, and open flame.
Storage: Store in tightly sealed containers, preferably amber glass or approved chemical-resistant plastic, in cool, dry, and well-ventilated areas. Separate from food and incompatible materials such as strong acids, oxidizers, or bases. Keep out of direct sunlight.
Special Instructions: Use secondary containment for bulk quantities. Rotate stock based on date received to maximize shelf life and reduce risk of degradation.

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits specific to Vindoline Tartrate. Since it is not a commercial bulk chemical, exposure is controlled by best laboratory practices.
Engineering Controls: Utilize fume hoods or local exhaust when handling powders.
Personal Protective Equipment: Wear gloves, safety goggles, and laboratory coat. Use an approved particulate respirator if dust generation cannot be avoided.
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing before leaving the work area, do not eat or drink in work zones.

Physical and Chemical Properties

Appearance: White to pale yellow crystalline powder
Odor: Odorless or slightly organic
Melting Point: Approximately 206-208°C
Solubility: Freely soluble in water (due to tartrate salt), sparingly soluble in ethanol and other polar solvents
pH (aqueous solution): Product tends acidic in aqueous media
Vapor Pressure: Not applicable, non-volatile solid
Boiling Point: Decomposes before boiling
Relative Density: Varies by hydration, typically about 1.35 g/cm³
Flash Point: Not flammable under normal laboratory conditions
Partition Coefficient: Not determined

Stability and Reactivity

Chemical Stability: Stable under typical laboratory storage and usage, avoid extensive moisture and strong light.
Reactivity: Not reactive with most common materials
Incompatible Materials: Strong oxidizing agents, reducing agents, strong acids or bases
Hazardous Decomposition Products: Thermal decomposition yields carbon oxides, nitrogen oxides, and possibly tarry organic residues.
Polymerization: No hazardous polymerization expected

Toxicological Information

Acute Toxicity: Data for Vindoline Tartrate is limited, though oral and dermal toxicity is considered moderate based on related indole alkaloids; ingestion or inhalation produces symptoms ranging from gastrointestinal upset to neurological effects.
Skin and Eye Contact: Can cause irritation on repeated or prolonged exposure; severe reactions are uncommon but possible, especially for sensitive individuals.
Inhalation: May cause respiratory tract irritation, coughing, and sneezing.
Chronic Effects: Evidence is lacking for carcinogenicity, mutagenicity, or reproductive toxicity, though prudent handling treats all alkaloids with care.
Sensitization: Individuals with allergies to plant alkaloids may develop skin reactions.

Ecological Information

Ecotoxicity: No comprehensive studies have been conducted, but as an indole alkaloid, expect moderate toxicity to aquatic and soil microorganisms at high concentrations.
Persistence and Degradability: Likely to degrade slowly via typical environmental processes; breakdown accelerates under sunlight.
Bioaccumulation: Potential low, insufficient data for definite claims.
Mobility: Water-soluble form can migrate through moist soils.
Avoid Release: Advised never to discharge into waterways, sewers, or natural surroundings.

Disposal Considerations

Waste Treatment: Dispose as hazardous laboratory waste, following institutional and national guidelines.
Methods of Disposal: Incinerate in approved facility or use a permitted chemical disposal contractor; do not pour down the drain.
Contaminated Packaging: Rinse thoroughly before discarding, or dispose of as hazardous lab waste.
Regulatory Waste Codes: Refer to local appropriate hazardous waste identification numbers.

Transport Information

UN Number: Not assigned; substance rarely transported in bulk
Shipping Name: Vindoline Tartrate, chemical for laboratory use
Hazard Class: Not classified as dangerous for transport under most national/international regulations
Packing Group: Not required
Special Precautions: Ensure secure packaging against spillage; shipments should comply with institutional policies for research chemicals.
Regulatory Compliance: Transport always by authorized couriers or within compliance of local chemical transport laws.

Regulatory Information

Safety, Health, and Environmental Regulations: No specific global regulatory listings for Vindoline Tartrate; handle according to general laboratory chemical policies, including OSHA Laboratory Standard, Canada’s WHMIS, and EU REACH.
Hazard Symbol: No established pictogram in most regulatory systems, but laboratory sheets generally use exclamation mark for irritant classification.
Inventory Status: Typically not listed on bulk chemical inventories because it is used mainly in research or pharmaceutical production.
Other Regulatory Notes: Maintain clear documentation from acquisition to disposal; labs must log usage per controlled substance protocols, even if not scheduled.