Substance Name: Tylosin Phosphate / Tylosin Tartrate
Common Names: Tylosin, Tylan
Chemical Formula: Tylosin Phosphate: C46H77NO17·H3PO4; Tylosin Tartrate: C46H77NO17·C4H6O6
CAS Number: Tylosin Phosphate: 1405-69-0; Tylosin Tartrate: 74610-55-2
Intended Use: Veterinary antibiotic, feed additive for livestock
Manufacturer Information: Provided by supplier or commercial packaging
Emergency Contact: Local poison control center or supplier emergency line
Physical State: Powder or granules
Color: Off-white to yellow
GHS Classification: Eye irritation Category 2, Skin sensitization Category 1, Specific Target Organ Toxicity (single exposure) Category 3
Signal Word: Warning
Hazard Statements: Causes serious eye irritation. May cause allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: Wear protective gloves and eye protection. Do not breathe dust. Wash hands after handling.
Potential Health Effects: Allergic reactions on skin contact, respiratory discomfort upon inhalation, eye irritation
Environmental Hazards: Harmful to aquatic life, risk of antibiotic resistance in natural environments
Main Component: Tylosin (as phosphate or tartrate salt)
Eye Contact: Rinse with running water for several minutes. Remove contact lenses if present and easy to do. Seek medical attention for persistent irritation.
Skin Contact: Remove contaminated clothing. Wash affected skin with plenty of water and soap. If rash or irritation occurs, get medical advice.
Inhalation: Move person to fresh air. Provide artificial respiration if needed. Seek medical help if symptoms persist.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Contact a physician or poison control center.
Note to Physician: Treat symptomatically. Monitor for allergic reactions, respiratory distress.
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Direct water jet can spread dust
Hazards from Combustion: Thermal decomposition may release toxic fumes, including carbon monoxide, carbon dioxide, nitrogen oxides, phosphorus oxides
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Special Procedures: Keep containers cool with water spray. Avoid inhalation of combustion products. Prevent runoff from entering waterways.
Personal Precautions: Wear gloves, safety goggles, dust mask or respirator. Restrict contact with skin and eyes. Ensure adequate ventilation.
Environmental Precautions: Prevent entry into drains, water bodies, or soil.
Methods for Cleanup: Sweep or vacuum up spill using non-sparking tools. Place in labeled containers for disposal. Dampen down dust with moistened absorbent.
Decontamination: Wash spill area with soap and water. Dispose of cleaning materials as hazardous waste.
Handling: Avoid breathing dust. Prevent contact with skin, eyes, and clothing. Use in well-ventilated areas. Handle away from food, feed, and potable water. Use appropriate PPE.
Storage Conditions: Keep in tightly closed original containers. Store in a cool, dry place away from direct sunlight and heat sources. Separate from oxidizers, acids, and food materials.
Incompatibilities: Strong acids and oxidizers can degrade or react with the product.
Hygiene: Wash hands before breaks and after handling. Do not eat, drink, or smoke during use.
Occupational Exposure Limits: No established limits; workplace exposure should be minimized through local exhaust or general ventilation.
Engineering Controls: Use local exhaust to control dust levels. Enclose processes, use clean-up systems that do not generate dust.
Personal Protection:
Appearance: Fine off-white to yellow powder or granules
Odor: Faint, characteristic
Odor Threshold: Not determined
pH (solution): 6.0–8.5
Melting Point/Freezing Point: Decomposes before melting
Boiling Point: Not applicable; decomposes
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible
Vapor Density: Not applicable
Solubility: Slightly soluble in water (tartrate more soluble than phosphate)
Partition Coefficient: n-octanol/water: Not available
Decomposition Temperature: Above 190ºC
Viscosity: Not applicable
Bulk Density: 0.3–0.6 g/cm³
Chemical Stability: Stable under recommended storage conditions
Reactive Hazards: Dust can form explosive mixtures with air
Incompatible Materials: Strong acids, strong oxidizers
Conditions to Avoid: Heat, sparks, open flames, moisture
Hazardous Decomposition Products: Oxides of carbon, nitrogen, phosphorus, and other toxic gases on combustion or decomposition
Polymerization: Not expected
Acute Toxicity: Oral LD50 (rat) > 5,000 mg/kg (low acute toxicity)
Dermal: May cause mild irritation in sensitive persons
Inhalation: Dust can irritate respiratory tract, possible allergic reactions
Eye: Irritating to eyes; redness and soreness may result
Skin: Allergic reactions have been reported among veterinary and laboratory workers
Chronic Effects: Prolonged exposure may sensitize individuals, causing skin or respiratory allergies
Mutagenicity/Carcinogenicity: No evidence in studies for mutagenic or carcinogenic potential
Target Organs: Skin, eyes, respiratory system
Medical Conditions Aggravated by Exposure: Asthma, allergies, skin conditions
Ecotoxicity: Harmful to aquatic organisms. Alters soil and water microbial balance. Long-term exposure may promote antibiotic-resistant bacteria in the environment.
Mobility in Soil: Moderately mobile; may leach to groundwater in certain conditions
Persistence and Degradability: Biodegradable over time, but may persist in low-oxygen soil or water
Bioaccumulation: Unlikely due to metabolism and excretion by organisms
Other Effects: Disruption of beneficial bacteria in ecosystems, risk of contamination along food chains
Product Disposal: Dispose as hazardous pharmaceutical waste in accordance with national and local regulations. Do not discharge into drains, watercourses, or environment.
Contaminated Packaging: Triple rinse empty containers, then puncture and dispose at approved landfill or incineration facility.
Incineration: Suitable methods include high-temperature incineration with gas scrubbing.
Recycling: Not recommended due to residue contamination.
Precautions: Ensure waste handlers wear full PPE and work in well-ventilated conditions.
UN Number: Not classified as hazardous for transport under UN, IATA, or IMDG codes
Proper Shipping Name: Not regulated
Hazard Class: Not regulated
Packing Group: Not regulated
Special Precautions: Transport in sealed, labeled containers. Protect from moisture and physical damage. Keep away from foodstuffs and feed during transport.
Emergency Response Guide Number: Not applicable
US Regulations: Tylosin included on EPA list of veterinary antibiotics; subject to FDA veterinary drug and feed additive regulations
EU Regulations: Listed under Regulation (EC) No 1831/2003 as feed additive; prescription-only status in many countries
Worker Protection: Subject to OSHA Hazard Communication Standard (29 CFR 1910.1200), REACH registered in EU
Environmental: Controlled use to prevent antibiotic resistance under WHO and FAO guidelines
Labeling Requirements: Include risk/hazard information, instructions for safe handling, storage, and disposal as per GHS
Other Regulations: Local restrictions may apply to use or disposal. Check with local authorities.
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