Product Name: Tylosin Tartrate and Sulfadimidine Soluble Powder
Chemical Name: Tylosin Tartrate: 4-O-(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)-20-O-(6-deoxy-3-C-methyl-alpha-L-mannopyranosyl)tylosin tartrate; Sulfadimidine: 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
Manufacturer: Major agrivet pharmaceutical companies, contact info found on product packaging
Application: Veterinary antibiotic powder for dilution in water
Emergency Phone: Local poison control or company-provided emergency number
Recommended Use: Treatment of susceptible bacterial infections in livestock
Product Code: Refer to packaging or supplier documentation
Synonyms: SULFAMETHAZINE, Tylosin tartrate, Water Soluble Antibiotic
Hazard Classification: Classified as hazardous according to GHS, irritant to respiratory system, eyes, and skin; Risk of allergic reactions in sensitive individuals
Label Elements: Warning symbol (exclamation), signal word: WARNING
Health Hazards: May cause skin and eye irritation, respiratory sensitization possible especially for individuals with sulfonamide or macrolide allergies
Environmental Hazards: Product is toxic to aquatic life at high concentrations, avoid release to environment
Physical Hazards: Combustible as a dust; powder may form explosive mixtures with air
Other Information: May cause long-term effects in aquatic environments
Tylosin Tartrate: 20–50% by weight; CAS No.: 1405-69-0
Sulfadimidine (Sulfamethazine): 40–80% by weight; CAS No.: 57-68-1
Excipients: Dextrose, lactose or other bulking agent: balance to 100%
Impurities: Typically less than 1%, no relevant hazardous impurities reported in finished product
Form: Free-flowing yellow to off-white powder
Inhalation: Move person to fresh air, seek medical attention if symptoms persist such as breathing difficulty, wheezing, or chest tightness
Eye Contact: Rinse eyes gently with water for several minutes, remove contact lenses, continue rinsing;
Skin Contact: Wash affected area thoroughly with soap and water, seek medical advice for irritation or allergic reaction
Ingestion: Rinse mouth with water, do not induce vomiting, get medical attention for large amounts or if feelings of unwellness occur
Most Important Symptoms: Allergic reactions, skin/eye irritation, respiratory discomfort; aggravation of existing asthma
Advice to Physician: Treat symptomatically with attention to allergies to antibiotics
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable Extinguishing Media: High pressure water streams may disperse dust
Hazardous Combustion Products: Oxides of carbon, nitrogen oxides, sulfur oxides, irritating fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Special Precautions: Powder can form explosive mixtures with air; avoid raising dust clouds; ventilate area post-fire
Additional Measures: Remove undamaged containers from area if possible
Personal Precautions: Wear PPE including gloves, goggles, and dust mask or respirator
Environmental Precautions: Prevent untreated release to drains, soil, surface water
Spill Cleanup Methods: Avoid generating dust; sweep up powder gently, place in a labeled container for disposal;
Decontamination: Wash area and equipment with water and detergent, rinse thoroughly
Disposal: Dispose in accordance with applicable local, regional and national regulations
Reporting: Inform regulatory bodies if significant environmental contamination occurs
Handling: Use in well-ventilated areas, minimize dust generation, avoid inhalation and contact with skin or eyes, wash hands after handling
Storage: Store in tightly-closed original container, in a cool (below 30°C), dry, well-ventilated area, protected from light
Segregation: Keep away from incompatible materials such as oxidizers
Other Handling Information: No eating, drinking, or smoking in working area, keep out of reach of children, always use clean and dry measuring utensils, label containers clearly
Shelf Life: Typically 2–3 years under recommended storage conditions
Engineering Controls: Local exhaust ventilation and/or enclosure recommended where dust or aerosols are generated
Exposure Limits: No national or international exposure limits set specifically for finished product; workplace exposure limits for dust should be applied (e.g., ACGIH TLV for particulates)
Personal Protective Equipment (PPE): NIOSH/MSHA approved dust respirator, safety glasses or goggles, chemical resistant gloves (nitrile, neoprene), lab coat or apron
Hygiene Measures: Wash hands before breaks and after handling; avoid hand-to-mouth or hand-to-eye contact
Environmental Controls: Use containment for bulk handling, avoid release to surface water/sewer/drains
Special Sensitivity: Individuals with known allergies to tylosin, macrolides or sulfonamides should avoid exposure
Appearance: Yellowish to off-white crystalline powder
Odor: Weak, characteristic odor possibly medicinal
Odor Threshold: Not established
pH (1% solution): 4.0–6.0
Melting Point: Decomposes prior to melting; reference literature for pure substances
Boiling Point: Not applicable for solid mixture
Solubility in Water: Freely soluble, forms clear to slightly turbid solution
Partition Coefficient (n-octanol/water): Not available for mixed product
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Bulk Density: Approximately 0.5–0.7 g/cm³
Flash Point: No data, combustible as a dust
Explosive Properties: Dust may give explosive mixture with air
Particle Size: Fine powder/granular solid
Chemical Stability: Stable under normal conditions of use and storage
Thermal Decomposition: May decompose at high temperatures producing hazardous gases
Incompatible Materials: Strong oxidizers, acids, bases; avoid mixing with additional reactive antibiotics
Conditions to Avoid: Extreme heat, strong sunlight, moisture, direct contact with oxidizing agents
Hazardous Decomposition: Combustion may yield CO, CO₂, nitrogen oxides, sulfur compounds
Polymerization: No known risk of hazardous polymerization
Routes of Exposure: Dermal, inhalation, oral, ocular
Acute Toxicity: LD50 (oral, rat) tylosin tartrate: >5000 mg/kg; LD50 (oral, rat) sulfadimidine: ~4,000 mg/kg
Chronic Toxicity: Prolonged or repeated exposure may cause allergic reactions, liver or blood disorders
Sensitization: Product has high probability to cause allergic reactions in susceptible persons
Irritation: Skin and eye irritation, particularly with prolonged contact
Mutagenicity and Carcinogenicity: No reliable evidence of carcinogenicity at recommended exposures; experimental high doses and long-term misuse carry risk
Reproductive Toxicity: Not clearly established but possible risks have been noted in animal studies at high doses
Symptoms of Overexposure: Nausea, headache, dizziness, rash, respiratory distress, hypersensitivity reactions
Medical Conditions Aggravated by Exposure: Asthma, sulfite sensitivity, pre-existing allergies
Ecotoxicity: Toxic in aquatic environments (acute and chronic exposure), risk of bioaccumulation, antibiotics can contribute to resistance development among environmental bacteria
Persistence and Degradability: Some components degrade slowly in soil or water, possible environmental persistence especially with repeated exposures
Mobility in Soil: Moderate mobility for sulfonamides, tylosin less mobile; both can leach in sandy or low-organic soils
Bioaccumulative Potential: Low for Tylosin; variable for Sulfadimidine
Other Adverse Effects: Release into waterways should be avoided to prevent impact on aquatic life and resistome
Additional Information: Monitor effluent and waste streams during bulk use or manufacturing
Waste Generation: Non-reusable product, contaminated packaging or spill cleanup material
Disposal Methods: Dispose through licensed chemical waste contractor, incineration recommended
Disposal of Containers: Triple rinse, puncture, and render unusable before disposal according to local regulations
Special Instructions: Do not discharge into drains/waterways; avoid landfill disposal if incineration is possible
Legal Obligations: Disposal must meet local, state, and national environmental regulations; consult with authorities as necessary
UN Number: Not classified as dangerous goods by ADR/RID, IMDG, or IATA
Transport Hazard Class: Not regulated as hazardous in transport
Packing Group: Not applicable
Proper Shipping Name: Tylosin Tartrate and Sulfadimidine Soluble Powder
Special Precautions: Secure containers to prevent leaks, avoid shipping with food or feed products
Environmental Hazards During Transport: Prevent dust release or spillage; notify receiving party of handling precautions
Labeling Requirements: Product label must reflect ingredient list, hazard warnings, handling precautions, and regulatory symbols
International Inventories: Ingredients listed in several national chemical inventories (e.g., TSCA, EINECS, Canada DSL)
OSHA Status: Considered hazardous per OSHA Hazard Communication Standard
SARA/Title III: Not subject to SARA Title III section 313 reporting
WHMIS Classification (Canada): D2B (Toxic materials causing other toxic effects)
Other Local/National Regulations: Subject to veterinary medicines regulations and prescription requirements in most countries; follow import, use, and disposal regulations strictly
Specific Prohibitions: Prohibited for extralabel use in food-producing animals in some jurisdictions; prohibited in certain species as outlined by veterinary authorities
Providing high-quality chemical products and logistics solutions for global trade partners.
