Product Name: Tylosin Tartarate
Chemical Family: Macrolide antibiotic
Synonyms: Tylosin tartrate, Tylovet tartrate, Tylan tartrate
CAS Number: 1405-54-5
Recommended Use: Veterinary antimicrobial for animals
Manufacturer: Veterinary pharmaceutical supplier
Contact Information: Emergency telephone number and address of producer
GHS Classification: Eye irritation (Category 2A), Skin sensitizer (Category 1), Respiratory sensitization (Category 1)
Label Elements: Warning symbol, Exclamation mark, Health hazard pictogram
Hazard Statements: Causes eye irritation, May cause allergic reactions if inhaled or in contact with skin, Not intended for human consumption
Precautionary Statements: Avoid breathing dust, Wear protective gloves, If exposed seek medical advice, Wash hands thoroughly after handling
Chemical Name: Tylosin Tartarate
Common Name: Tylosin tartrate
Concentration: 100% (active ingredient), may be supplied as powder
Impurities: Trace microbial or manufacturing-related substances possible
Molecular Formula: C46H77NO17·C4H6O6
Molecular Weight: Approx. 1060.2 g/mol
Inhalation: Move exposed individual to fresh air, maintain breathing, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, refer to physician if irritation persists
Eye Contact: Rinse eyes with water for several minutes, remove contact lenses if present and easy to do, get medical help in case of persistent irritation
Ingestion: Rinse mouth, do not induce vomiting, drink water if able, medical assistance required
Most Important Symptoms: Allergic reactions, eye or skin irritation, respiratory distress in sensitized persons
Notes for Physician: Treat symptoms, show the safety data sheet, symptomatic treatment; allergic reactions may require specific intervention
Suitable Extinguishing Media: Water spray, carbon dioxide, foam, dry chemical
Unsuitable Extinguishing Media: High-pressure water jet may spread contamination
Specific Hazards: Decomposition releases toxic fumes (carbon oxides, nitrogen oxides, sulfur oxides)
Protective Equipment: Firefighters require self-contained breathing apparatus, full protective clothing
Advice for Firefighters: Prevent runoff from contaminating water sources, use water spray to cool containers
Personal Precautions: Wear protective gloves, gown, and mask, prevent dust formation
Environmental Precautions: Avoid discharge into drains, soil, watercourses; collect for disposal
Methods for Cleanup: Sweep spilled material into containers, avoid creating dust, ventilate area, dispose of solid safely in approved manner
References: Avoid using vacuum that could disperse dust; use damp disposable towels if possible; wash spill site after pickup
Safe Handling: Use personal protective equipment, work in a well-ventilated space, avoid splashing, minimize dust
Hygiene Practices: Wash hands before eating, drinking, or using bathroom, remove and wash contaminated clothing
Storage Conditions: Store in tightly closed original container, keep in a cool, dry, well-ventilated place away from incompatible substances (like strong oxidizers)
Incompatibilities: Do not store with acids, peroxides, or oxidizers
Exposure Limits: No specific OSHA or ACGIH limits; recommend minimizing exposure
Engineering Controls: Use fume hoods, local exhaust, or general ventilation
Personal Protective Equipment (PPE): Chemical-resistant gloves, lab coat or coveralls, closed-toe shoes, safety goggles, face mask or respirator in dusty conditions
Environmental Controls: Prevent material from entering sewers or water systems; handle waste as hazardous
Appearance: White to slightly yellowish hygroscopic powder
Odor: Faint, characteristic antibiotic odor
Melting Point: Approximately 160°C (decomposes)
Solubility: Soluble in water and polar organic solvents
pH: Solution pH usually near neutral (6.0–7.0)
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not measurable (solid)
Flash Point: Data not available
Partition Coefficient: Not determined due to high molecular weight
Density: Approx. 1.2–1.4 g/cm³
Chemical Stability: Stable under recommended storage conditions
Possible Hazardous Reactions: No significant hazardous polymerization
Conditions to Avoid: Excess heat, high humidity, incompatibilities
Incompatible Materials: Strong oxidizing agents, acids, peroxides
Decomposition Products: Decomposition at high temperatures produces toxic fumes including carbon monoxide, nitrogen oxides, sulfur oxides
Acute Toxicity: LD50 (oral, rat) > 5,000 mg/kg, very low acute toxicity in animal models
Chronic Exposure: Repeated exposure can lead to allergic sensitization, particularly respiratory or skin; some reports of liver enzyme changes
Symptoms of Overexposure: Eye and skin irritation, headache, cough, difficulty breathing for sensitive individuals
Carcinogenicity: Not listed by IARC, NTP, or OSHA as carcinogenic
Mutagenicity: No evidence for mutagenic effects in available studies
Reproductive Toxicity: No observed reproductive effects at standard use levels
Ecotoxicity: Toxic to aquatic organisms in high concentrations; not readily biodegradable
Persistence and Degradability: Moderate persistence in animal waste and runoff soils; slow degradation in water
Bioaccumulation: Potentially bioaccumulative in aquatic species
Mobility in Soil: Moderate mobility, leaching possible in loose soils; risk for contamination of surface water
Other Adverse Effects: Risk of antimicrobial resistance if residues reach environment; oversight in veterinary applications crucial to prevent ecosystem impact
Disposal Methods: Dispose of as hazardous pharmaceutical waste, incineration preferable; avoid landfilling untreated bulk material
Contaminated Packaging: Destroy packaging according to national and local hazardous waste regulations
Precautions: Prevent material release to environment, follow veterinary and environmental laws
Regulatory Compliance: Confirm local waste management policies for pharmaceuticals; avoid mixing with municipal trash
UN Number: Not regulated for transport in most jurisdictions
Proper Shipping Name: Not classified as dangerous goods
Hazard Class: N/A
Packing Group: N/A
Transport Labels: Not required
Special Precautions: Pack to prevent dust release, avoid direct contact during handling and transit
U.S. Regulations: Not subject to specific TSCA, CERCLA, or SARA Title III reporting, considered a prescription veterinary drug
Europe: Subject to regulation under veterinary pharmaceuticals directives, not considered hazardous under CLP for transport
Canada: Prescription drug per Drug Schedule, follow Veterinary Drugs Directorate guidance
Global: Handle as an environmentally persistent substance, observe maximum residue limits in food animals; national veterinary and environmental compliance essential
Workplace Regulation: Use recommended PPE under OSHA Laboratory Standard or similar mandates
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