Product Name: Tylosin Hydrogen Tartrate
Chemical Formula: C46H77NO17 · C4H6O6
CAS Number: 1405-69-0
Synonyms: Tylosin tartrate, Tylan tartrate
Recommended Use: Veterinary antibiotic, primarily for livestock
Supplier: Contact manufacturer or distributor for details
Emergency Contact: Refer to local guidelines and supplier information
Relevant Identified Uses: For animal use, not intended for human consumption
Classification: Irritant; Sensitizer (sensitization can occur via skin or respiratory tract exposure)
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms or breathing difficulties, eye irritation, and skin sensitization; Prolonged or repeated exposure may cause adverse effects
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust or aerosols; wash hands thoroughly after handling; use personal protective equipment
Routes of Exposure: Inhalation, eye contact, skin contact, ingestion
Acute Effects: Irritation to eyes, skin, and respiratory tract
Chronic Effects: Risk for occupational asthma and respiratory sensitization
Main Ingredient: Tylosin hydrogen tartrate (Active pharmaceutical ingredient)
Concentration: ≥80% w/w (typical ranges may apply based on manufacturing process)
Impurities: Minor constituents may include fermentation byproducts and residual tartrate carriers (de minimis quantities)
Chemical Nature: Macrolide antibiotic, fermentation product of Streptomyces fradiae
Other Constituents: Moisture, possible trace minerals from fermentation process
CAS Number: 1405-69-0 (Tylosin); Tartrates (77-92-9, depending on variant)
Eye Contact: Flush eyes cautiously with plenty of water for several minutes; remove contact lenses if present and easy to do; seek medical attention if irritation develops or persists
Skin Contact: Wash area with soap and water; remove contaminated clothing; seek medical advice if rash or irritation occurs
Inhalation: Move to fresh air immediately; seek medical advice if symptoms such as coughing or shortness of breath develop; provide artificial respiration if difficulties in breathing
Ingestion: Rinse mouth with water; seek immediate medical attention; do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Allergic reactions, mild respiratory distress, skin or mucous membrane irritation
Notes for Medical Personnel: Treat symptoms; monitor allergic reactions closely, especially for asthmatic responses
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide foam
Hazards from Combustion: Burning may produce irritating or toxic fumes including carbon oxides, nitrogen oxides, and sulfur oxides
Special Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing to prevent contact with skin, mucous membranes, and eyes
Firefighting Procedures: Avoid entry to confined spaces without proper protective gear; use water spray to cool containers; prevent runoff from entering drains or waterways
Personal Precautions: Use personal protective equipment including gloves, goggles, and NIOSH-approved respirator
Environmental Precautions: Prevent leakage into environment or water course; contain dust and spillage to minimize spread
Clean-Up Methods: Absorb powder or granules using damp, disposable material; sweep up gently to avoid dust generation; place in appropriate waste container for disposal
Decontamination: Wash spill area thoroughly with water; ventilate the area
Reporting Requirements: Notify appropriate local authorities if contamination of watercourses or sewer occurs
Handling: Avoid generating dust; handle in well-ventilated area; wear suitable protective equipment; avoid contact with skin, eyes, or clothing
Storage Conditions: Store in tightly closed original container, away from sunlight, heat sources, and incompatible materials ( acids, oxidizers )
Storage Temperature: Keep in a cool, dry place (preferably below 25°C/77°F)
Incompatibilities: Strong acids, strong oxidizing agents
Hygiene Practices: Wash hands and exposed skin after use; do not eat, drink, or smoke while handling material
Engineering Controls: Use local exhaust ventilation or process enclosure to minimize exposure and dust generation
Personal Protective Equipment: Protective gloves (nitrile or latex), safety goggles, lab coat, and dust respirator (NIOSH N95 or higher)
Respiratory Protection: Use approved particulate respirator if exposure limits may be exceeded or symptoms occur
Skin Protection: Impermeable gloves and protective clothing to prevent skin exposure
Eye/Face Protection: Safety goggles or face shield
Exposure Limits: No specific occupational exposure limits established; minimize exposure as much as possible due to sensitization potential
Environmental Controls: Prevent release into the environment, especially water and soil
Appearance: Pale yellow to off-white powder or crystalline solid
Odor: Slight, characteristic odor, similar to mold or earth
pH (1% solution in water): Approx. 5.0–7.5
Solubility: Freely soluble in water; slightly soluble in alcohol
Melting Point/Freezing Point: Not well defined, decomposes before melting
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible at room temperature
Flash Point: Not flammable under normal conditions
Bulk Density: 0.4–0.7 g/cm³ (varies with product form)
Partition Coefficient (log Kow): Data not available
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to extreme heat, direct sunlight, and humidity
Incompatible Materials: Strong acids, bases, and oxidizers
Hazardous Decomposition Products: CO2, CO, nitrogen oxides, sulfur oxides, organic vapors
Hazardous Reactions: No hazardous polymerization expected
Reactivity: May react with strong acid or oxidizing conditions; stable in dry form
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity (oral/dermal/inhalation): Oral LD50 (rat) >5000 mg/kg (low acute toxicity in animal studies)
Skin Corrosion/Irritation: Mildly irritating to skin with prolonged exposure
Eye Damage/Irritation: Mildly irritating
Respiratory Sensitization: May cause allergic reactions or asthma in sensitized individuals
Dermal Sensitization: Prolonged or repeated exposure may cause allergic dermatitis
Chronic Toxicity: No definitive carcinogenic, mutagenic, or reproductive hazards identified in studies; long-term exposure to antibiotics may contribute to bacterial resistance
Symptoms of Overexposure: Skin rash, respiratory distress, eye redness, allergic reactions
Medical Conditions Aggravated by Exposure: Asthma, hypersensitivity, existing allergies
Ecotoxicity: Harmful to aquatic organisms, may cause long-term effects in the aquatic environment
Persistence and Degradability: Partly biodegradable under environmental conditions, but breakdown may be slow in soil or water
Bioaccumulative Potential: No significant bioaccumulation expected; macrolide antibiotics may impact environmental bacteria
Mobility in Soil: Moderately mobile; possible leaching to groundwater from concentrated spills
Other Adverse Effects: Risk of antimicrobial resistance development in exposed animal or aquatic populations
Water Hazard Class: WGK 2 (water pollutant, German regulation)
Disposal Methods: Dispose of material and contaminated packaging through a licensed waste disposal contractor; incineration recommended for pharmaceutical waste
Waste Codes: Refer to local/state/federal regulations; typically categorized as pharmaceutical waste
Container Disposal: Rinse and dispose of containers per local guidance; do not reuse container
Precautions: Do not dispose of in household garbage, sewage or regular landfill; avoid environmental contamination
UN Number: Not classified as dangerous goods for transport by ADR/RID, IMDG, or IATA
Proper Shipping Name: Tylosin hydrogen tartrate
Transport Hazard Class: Not a dangerous good
Packing Group: Not regulated
Environmental Hazards: Not regulated for bulk transport; use caution to avoid spills and release to watercourse
Special Precautions: Protect from excessive heat, moisture, and physical damage; transport in original, securely closed packaging
Federal Regulations: Not listed as a hazardous substance under US OSHA Hazard Communication Standard; not regulated as a carcinogen under IARC, NTP, or OSHA
EU Classification: Classified as hazardous under EC 1272/2008 (CLP Regulation): Sensitizing; irritant
Inventory Status: Listed or exempt under relevant national chemical substance inventories
Labeling Requirements: Product label must include hazard statements, precautionary statements, supplier contact information, and emergency number
Restrictions: Veterinary use only; not for use in humans; sale and distribution may require appropriate veterinary prescription or permit depending on jurisdiction
Other Regulations: Comply with local, national, and international regulations for handling and disposal of antibiotics and veterinary drugs
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