Product Name: Trivalent Sodium Antimonyl Gluconate
Chemical Formula: C12H22Na3O16Sb
Synonyms: Sodium stibogluconate, Pentostam
CAS Number: 1229-96-1
Intended Use: Pharmaceutical applications, especially antiprotozoal treatment
Manufacturer: [Company Name and Address]
Emergency Phone: [Emergency contact number, local poison control]
GHS Classification: Acute toxicity (oral, dermal, inhalation); Eye irritation; Specific target organ toxicity
GHS Label Elements: Signal word: Warning; Hazard pictograms: exclamation mark, health hazard
Potential Health Effects: Symptoms of toxicity include headache, abdominal pain, dizziness, nausea, vomiting, rash, cardiac abnormalities, and hepatotoxicity
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Environmental Hazards: Harmful to aquatic life; avoid release to environment
Chemical Name: Sodium antimonyl gluconate
Concentration: ≥95% (active ingredient)
Other Components: Water (for injectable solutions); residual gluconic acid derivatives
Impurities: Antimony (III) content controlled; heavy metals below pharmacopoeial limits
Inhalation: Move person to fresh air; monitor respiratory status; seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing; rinse skin with copious water; seek medical care if irritation develops or persists
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if possible; obtain medical evaluation
Ingestion: Rinse mouth; do not induce vomiting; provide water to dilute; seek immediate medical attention
Acute Exposure Symptoms: Immediate symptoms include gastrointestinal upset, respiratory difficulty, arrhythmias in severe cases
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: No specific restrictions, avoid high-pressure water streams
Specific Hazards: Material itself is not highly flammable; thermal decomposition can yield toxic antimony oxides and carbon oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), chemical protective clothing
Special Precautions: Avoid inhaling combustion products; evacuate area if large quantities are involved
Personal Precautions: Evacuate unnecessary personnel; wear gloves, goggles, respiratory protection
Environmental Precautions: Do not allow spillage to reach drains or waterways; inform appropriate authorities if environmental contamination occurs
Methods for Cleanup: For small spills, absorb with inert material (vermiculite, sand); scoop into suitable, labeled disposal containers
Decontamination: Ventilate area well; wash spill site with water after material pickup is complete
Handling: Use only in well-ventilated areas; avoid contact with skin and eyes; wear protective equipment; do not eat, drink, or smoke when handling
Storage Conditions: Store in original container, tightly closed, away from incompatible substances (strong oxidizers, acids/bases)
Temperature Requirements: Store at controlled room temperature (15–25°C / 59–77°F), protect from light and moisture
Storage Protection: Secure from unauthorized access; label storage area with chemical name and hazard information
Occupational Exposure Limits: Antimony (TWA): 0.5 mg/m³ (ACGIH), consult local regulations
Engineering Controls: Exhaust ventilation, local fume hoods at point of use, closed system transfer where possible
Personal Protective Equipment: Chemical-resistant gloves (nitrile or PVC), safety glasses or goggles, lab coat, NIOSH-approved respirator for dusts/mists
Hygiene Measures: Wash hands thoroughly after handling; remove contaminated clothing before breaks or leaving the work area
Appearance: White to off-white crystalline powder, sometimes supplied in solution
Odor: Odorless
pH: Neutral to slightly acidic (for solutions, ~5.0–7.0)
Melting Point: Decomposes before melting (specific data not available)
Solubility in Water: Freely soluble
Density: Approx. 1.8 g/cm³ (solid)
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not applicable
Partition Coefficient (log Kow): Data not available
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: May react with strong oxidizers, reducing agents, acids, or bases
Hazardous Decomposition Products: Toxic antimony oxides, carbon dioxide, carbon monoxide
Conditions to Avoid: Excessive heat, contact with incompatible materials, exposure to light
Polymerization: Will not occur
Acute Toxicity: LD50 (oral, rat): 100–300 mg/kg (antimony compounds); toxicity varies by route of exposure
Short-term Effects: Irritation of skin, eyes, gastrointestinal tract; dizziness, vomiting, muscle pain, cardiac effects
Chronic Exposure: Prolonged or excessive exposure can cause damage to liver, kidneys, heart, and nervous system
Carcinogenicity: Antimony compounds classified by IARC as Group 2B (possibly carcinogenic to humans); more data needed for this specific salt
Mutagenicity/Teratogenicity: Limited data; handle using established hazard controls for reproductive toxicants
Sensitization: May cause skin sensitization in some individuals
Aquatic Toxicity: Harmful to aquatic organisms, possible long-term adverse effects
Persistence/Degradability: Not readily biodegradable; antimony species may persist in the environment
Bioaccumulative Potential: Antimony can bioaccumulate in aquatic organisms; risk of food chain enrichment
Mobility in Soil: Moderately mobile, can leach to groundwater under some conditions
Other Adverse Effects: Avoid uncontrolled release to the environment
Waste Disposal Methods: Place in tightly sealed, labeled container; dispose of at licensed hazardous waste treatment facility
Container Handling: Rinse thoroughly before disposal; prevent contamination of surface and ground waters
Regulatory Requirements: Dispose in accordance with local, regional, national, and international regulations
UN Number: UN 3288 (Toxic solid, inorganic, n.o.s.)
Proper Shipping Name: Toxic solid, inorganic, n.o.s. (Contains antimony compound)
Hazard Class: 6.1 (Toxic Substance)
Packing Group: III
Transport Labels: Toxic (skull and crossbones)
Transport Precautions: Protect from physical damage, moisture, and temperature extremes during transit; emergency procedures as per MSDS in case of accident or spill
Transport regulations: Subject to IATA/ICAO, IMDG, ADR international codes for transport of dangerous goods
Safety Assessment: Regulated by pharmaceutical and workplace safety agencies
OSHA: Listed hazardous substance; exposure limited under OSHA antimony rules
EU Regulations: Classified according to Regulation (EC) No 1272/2008 (CLP/GHS); REACH status may apply
WHMIS (Canada): Classified as toxic
Other Regulations: Included on inventories (TSCA, EINECS); subject to additional state/province-specific limits and reporting requirements
Labeling Requirements: Follow all workplace labeling with correct pictograms and statements as regulated
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