Product Name: threo-2-amino-1-phenyl-1,3-propanediol
Synonyms: racemic 2-amino-1-phenyl-1,3-propanediol, threo-APD
Chemical Formula: C9H13NO2
Molecular Weight: 167.21 g/mol
CAS Number: 5794-45-6
Recommended Use: Organic synthesis, research laboratory
Manufacturer/Supplier: Chemical sourcing department or laboratory supply chain
Contact Information: See supplier records or laboratory inventory
Emergency Contact: Local poison control, fire department, or hospital toxicology unit
GHS Classification: Acute Toxic (Oral, Category 4), Eye Irritant (Category 2), Skin Sensitizer (Category 1)
Signal Word: Warning
GHS Pictograms: Exclamation mark
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause allergic skin reaction
Precautionary Statements: Avoid breathing dust or vapor, wash hands thoroughly after handling, wear gloves, eye protection, wash contaminated clothing
Routes of Exposure: Consumption, inhalation, skin and eye contact
Potential Health Effects: May cause drowsiness, nausea, headache if swallowed; can trigger skin redness or itching; eye contact can result in tearing or burning
Environmental Dangers: Not fully investigated, but may present hazard to aquatic organisms if released in large quantities
Chemical Name: threo-2-amino-1-phenyl-1,3-propanediol
CAS Number: 5794-45-6
Concentration: 98-100%
Impurities: Trace related compounds sometimes present as side-products from synthesis, typically below 1%
Stabilizers or Additives: None reported
Mixture Status: Pure substance, not a blend with other chemicals
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms like coughing, dizziness, or breathing difficulty persist
Skin Contact: Remove affected clothing, wash skin thoroughly with plenty of soap and water, avoid scrubbing or using harsh agents, seek medical review if irritation or rash develops
Eye Contact: Rinse eyes with lukewarm water for 15 minutes, use gentle but thorough flush, remove contact lenses if safe, seek ophthalmologist assessment for persistent symptoms
Ingestion: Rinse mouth gently, avoid inducing vomiting, give small quantity of water to drink if conscious, seek medical advice right away
General Advice: Always bring product label or packaging when contacting medical services
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, or foam
Unsuitable Media: Direct water stream at high pressure, which can cause spattering
Hazardous Combustion Products: Carbon monoxide, nitrogen oxides, possible other toxic fumes
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing, chemical-resistant gloves
Special Precautions: Chemical can cause hazardous fumes, use ventilation, remove containers from fire area if safe
Explosion Hazards: No data suggesting explosive properties for this substance
Personal Precautions: Wear chemical-resistant gloves, safety goggles, lab coat, avoid breathing in dust
Environmental Measures: Prevent chemical from entering drains, watercourses, or soil
Containment Methods: Use inert material, such as dry sand or vermiculite, to contain spill
Clean-up Methods: Scoop or sweep up solid, place in labeled disposal container, clean affected area with mild detergent and water
Notification Procedures: Report significant spills to local environmental agency if required
Safe Handling: Always use chemical with proper ventilation, avoid contact with eyes and skin, do not inhale dust, keep containers tightly closed, follow laboratory standard practice
Storage Conditions: Store in a cool, dry location, away from sources of ignition, segregate from strong acids and bases
Special Requirements: Use only non-sparking tools, avoid static discharge
Incompatibilities: Avoid oxidizing agents, reactive metals, strong acids
Occupational Exposure Limits: No established occupational exposure limits recorded; use good chemical hygiene
Engineering Controls: Laboratory fume hood, local exhaust venting, closed systems preferred for bulk processing
Personal Protective Equipment (PPE): Chemical splash goggles, nitrile or neoprene gloves, flame-resistant laboratory coat, closed-toe shoes
Respiratory Protection: NIOSH-approved dust mask or respirator in absence of proper ventilation
Hygiene Measures: Wash hands after handling, avoid eating, drinking, or smoking near work area
Appearance: White to off-white crystalline powder
Odor: Faint, often described as mild or unremarkable
Density: Approximately 1.17 g/cm³
Melting Point: 117-124°C
Boiling Point: Decomposes before boiling
Solubility: Readily soluble in water, soluble in ethanol, slightly soluble in chloroform
pH (1% solution): 6.5 to 8.0
Vapor Pressure: Negligible at room temperature
Flash Point: Not flammable under normal laboratory conditions
Partition Coefficient (Log Kow): Not well-established for this compound
Evaporation Rate: Not volatile at room temperature
Chemical Stability: Stable under recommended storage and handling practices
Possible Hazardous Reactions: Can react with acids and oxidizers, producing heat and possibly toxic gases
Conditions to Avoid: High humidity, exposure to high temperatures, contact with incompatible chemicals
Incompatible Materials: Strong acids, oxidizers, reducing agents
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides under fire or thermal decomposition
Likely Routes of Exposure: Eye, skin, oral, inhalation
Acute Toxicity: LD50 (oral, rat) is estimated near 600 mg/kg
Skin Irritation: May cause redness, itching in susceptible individuals
Eye Irritation: Expected to cause eye discomfort, redness, tearing
Respiratory Sensitization: Unlikely except in dust-generating situations
Carcinogenicity: No data from IARC, OSHA, or NTP regarding carcinogenic potential
Mutagenicity: No clear data indicating mutagenic risk
Reproductive Toxicity: Insufficient study, handle in line with chemical hygiene for unknowns
Other Effects: May cause central nervous system symptoms if swallowed in larger doses
Environmental Fate: Readily biodegradable in water and soil under favorable microbial conditions
Bioaccumulation Potential: Low due to moderate solubility and lack of lipophilicity
Aquatic Toxicity: Not systematically determined, but likely low at typical lab concentrations
Persistence and Degradability: Expected to degrade through microbial metabolism
Other Adverse Effects: Avoid large releases into waterways, may disrupt aquaria or sensitive aquatic systems
Disposal Method: Treat as chemical waste, incinerate in licensed facility, use hazardous waste bins
Contaminated Packaging: Rinse containers thoroughly before disposal, follow local and national regulations for hazardous waste
Special Instructions: Avoid disposal to landfill or sewer, label waste according to lab protocols
Regulatory References: Check local, state, and federal rules for chemical disposal
UN Number: Not assigned by UN GHS, check local transport rules
Shipping Name: Chemicals, N.O.S. (if shipped in large laboratory containers)
Transport Hazard Class: Not regulated under ADR, IMDG, IATA for laboratory quantities
Packing Group: Not classified
Special Transport Precautions: Keep container tightly closed, transport under secure seal, avoid major temperature variation
Environmental Hazards: Not specifically regulated as a marine pollutant
US TSCA: Included or presumed listed
Europe REACH: May require registration for use above 1 tonne/year, check with supplier
OSHA Hazard Communication: Classified as hazardous
SARA Title III (Sections 311/312): Acute health hazard
California Proposition 65: Not listed
Canadian DSL/NDSL: Check with chemical supplier for registration status
Other International Regulations: May be subject to additional requirements depending on country and application
Lab Use Limits: Follow institutional safety policy, risk assessment, and chemical hygiene plans
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