Product Name: Tartaric Acid Dihydrazide
Synonyms: Dihydrazide of Tartaric Acid
Chemical Formula: C4H8N4O4
CAS Number: 6445-23-4
Recommended Use: Laboratory reagent, industrial additive, intermediate in organic synthesis
Supplier: Refer to packaging for source or manufacturer
Emergency Contact: Local poison control center, emergency medical services, and company emergency line included on labeling
GHS Classification: Acute Toxicity – Oral (Category 4), Eye Irritation (Category 2A), Skin Sensitization (Category 1)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause allergic skin reaction, causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use personal protective equipment, remove contaminated clothing and wash before reuse
Symptoms of Exposure: Headache, nausea, skin reddening, eye tearing, abdominal discomfort
Chemical Name: Tartaric Acid Dihydrazide
Purity: ≥ 98% w/w (typical range 98-100%)
Impurities: May include trace amounts of hydrazine derivatives and residual solvents left from synthesis
Ingredient Contribution: Main functional chemical, no significant diluents noted in standard commercial product
Inhalation: Move the person to fresh air, keep at rest, seek medical attention if symptoms persist. Remove source of exposure.
Skin Contact: Remove contaminated clothing, rinse skin immediately with plenty of water and soap for at least 15 minutes, call medical help if irritation develops.
Eye Contact: Rinse cautiously with water for 15 minutes, remove contact lenses if present, seek immediate medical evaluation.
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, call poison control center or physician at once.
Notes for Physicians: Treat symptomatically and provide supportive therapy as indicated by patient’s response to exposure.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: High-pressure water jets
Special Hazards: Emits nitrogen oxides and carbon oxides on combustion, may produce toxic fumes under fire conditions
Protective Equipment for Firefighters: Wear full protective clothing and approved self-contained breathing apparatus
Fire-Fighting Procedures: Approach from upwind, use water spray to cool containers, avoid runoff into water sources, evacuate area in case of large fires
Personal Precautions: Evacuate unnecessary personnel, wear chemical resistant gloves, goggles, and clothing
Environmental Precautions: Contain spillage, avoid runoff into sewers and waterways, inform authorities if large spill occurs
Cleanup Methods: Collect solid spill using a shovel, avoid generating dust, store material in sealed containers for disposal, wash spill site with water after material pickup if appropriate
Decontamination: Use mild detergent and water, ensure ventilation during and after cleanup
Handling: Avoid inhaling dust and direct contact with eyes, skin, or clothing. Work in a well-ventilated area. Keep container tightly closed and use personal protective equipment.
Hygiene Measures: Thoroughly wash hands and any exposed skin after handling and before eating or drinking.
Storage: Store in a dry, cool, well-ventilated area protected from direct sunlight. Keep away from heat, sources of ignition, and incompatible materials such as strong oxidizers.
Special Storage Requirements: Keep in original or labeled chemical-resistant containers. Ensure secondary containment for bulk quantities.
Occupational Exposure Limits: No established limits for tartaric acid dihydrazide, but minimize exposure.
Engineering Controls: Use local exhaust ventilation or fume hood in laboratory settings.
Personal Protective Equipment: Chemical splash goggles, lab coat or impervious clothing, chemical-resistant gloves (nitrile, neoprene), suitable respiratory protection for dust if exposure risk presents.
General Protection: Avoid eating, drinking, or smoking in work area. Provide eyewash stations and safety showers near handling site.
Appearance: White to off-white crystalline powder
Odor: Characteristic but faint
Odor Threshold: Not established
pH (1% solution in water): 2.5-3.5
Melting Point/Freezing Point: 220–224°C (with decomposition)
Boiling Point/Range: Not available
Flash Point: Not flammable
Evaporation Rate: Not determined (solid at room temperature)
Flammability (solid, gas): May support combustion at high temperatures
Vapor Pressure: Negligible at ambient conditions
Vapor Density: Not applicable
Relative Density: 1.7–1.9 g/cm³
Solubility: Soluble in water, slightly soluble in alcohol
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not self-igniting
Decomposition Temperature: ≥220°C
Viscosity: Not applicable for granular solid
Molecular Weight: 164.13 g/mol
Chemical Stability: Stable under recommended conditions, but sensitive to light, heat, and moisture
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Conditions to Avoid: Excessive heat, humidity, exposure to light, sources of ignition
Hazardous Decomposition Products: May yield carbon monoxide, carbon dioxide, nitrogen oxides, and hydrazine derivatives on thermal breakdown
Polymerization: Not known to occur under normal handling and storage
Acute Toxicity: LD50 (oral, rat) estimated between 300-2000 mg/kg
Chronic Toxicity: No long-term animal studies publicly available, but related hydrazides may show reproductive or neurological effects after high doses in animals
Skin Contact: May cause irritation and allergic response in sensitive individuals
Eye Contact: Produces irritation, redness, tearing
Inhalation: Dust can lead to respiratory irritation, coughing
Ingestion: Nausea, vomiting, abdominal cramps possible
Sensitization: Positive results in some skin sensitization tests
Carcinogenicity: No indication of cancer risk from current animal studies
Mutagenicity: Limited mutagenic data, though similar compounds show weak or inconclusive mutagenic effects
Other Effects: Prolonged exposure may aggravate conditions like asthma, dermatitis
Ecotoxicity: No comprehensive data, but structurally similar compounds show low to moderate toxicity to aquatic organisms
Persistence and Degradability: Slowly biodegradable, breaks down in soil and water under aerobic conditions over time
Bioaccumulative Potential: Low, molecules do not persist in biological systems or accumulate in food chains
Mobility in Soil: Expected moderate to high, water solubility aids leaching into groundwater run-off
Other Adverse Effects: Large quantities may contribute to nutrient loading if released to waterbodies
Disposal Methods: Consult national and local regulations. Preferred method is controlled incineration at licensed waste facility, ensuring complete combustion and emission controls.
Container Handling: Triple rinse containers, perforate to prevent reuse, send to chemical waste facility.
Precautions: Do not dispose with household garbage or local landfill. Avoid discharge to sewage or natural waterways.
UN Number: Not classified as hazardous under current ADR/RID, IMDG, or IATA codes
Transport Hazard Class: Not regulated for land, sea, or air
Packing Group: Not applicable
Proper Shipping Name: Tartaric Acid Dihydrazide, non-hazardous for transport
Special Precautions for Users: Seal containers securely, protect from physical damage during movement, follow spill-response in transit if needed
Marine Pollutant: Not designated as a marine pollutant
OSHA: Not specifically regulated, standard precautions apply
TSCA (USA): Listed
REACH (EU): Substance registered or pre-registered
DSL/NDSL (Canada): Listed
Labeling Requirements: GHS compliant pictograms and signal words
Other National Inventories: Compliant where commercially distributed, check region-specific standards
Additional Regulation: Usage may fall under industrial or laboratory chemical safety rules
Restrictions: May have workplace exposure controls depending on jurisdiction; refer to relevant local and state chemical usage regulations
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