Product Name: Stibogluconate sodique
Chemical Name: Sodium stibogluconate
Synonyms: Pentostam, Antimony sodium gluconate
CAS Number: 16037-91-5
Molecular Formula: C12H21NaO16Sb
Intended Use: Pharmaceutical applications, treatment of leishmaniasis
Supplier: Pharmaceutical manufacturers and laboratory chemicals suppliers
Contact Information: Usually found on the product label or safety datasheet supplied by the manufacturer
Classification: Harmful if swallowed, irritant to skin and eyes, may cause respiratory irritation
Hazard Statements: May cause liver and kidney injury after repeated exposure, can cause systemic toxicity
Signal Word: Warning
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Avoid skin and eye contact, do not eat, drink, or smoke when using the product, use only outdoors or in a well-ventilated area
Other hazards: Chronic exposure may increase risk of cardiac, hepatic, and renal complications
Chemical Identity: Sodium stibogluconate
Components: Antimony in pentavalent form, sodium gluconate
Concentration: Usually supplied in sterile solution, 100 mg/mL antimony as sodium stibogluconate
Impurities and Stabilizers: Pharmaceutical products are typically free from significant impurities, but excipients or preservatives may be present
EC Number: Not Assigned
Inhalation: Move person to fresh air, monitor for signs of respiratory distress, seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek medical care for persistent irritation or burns
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, keep eyelids apart, seek medical attention if irritation persists
Ingestion: Rinse mouth with water, seek immediate medical attention, do not induce vomiting unless directed by a medical professional
Notes for Physicians: Monitor for cardiac, hepatic, and renal complications; symptomatic treatment advised
Suitable Extinguishing Media: Water spray, CO2, dry chemical, foam
Unsuitable Extinguishing Media: Do not use direct water jets on spills
Fire Hazards: May emit toxic fumes of antimony and sodium oxides under high temperatures
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Specific Hazards: Burning may release carbon monoxide, antimony oxides, sodium oxides, and other toxic gases
Special Procedures: Move containers from fire area if safe, prevent runoff from entering drains or waterways
Personal Precautions: Wear appropriate personal protective equipment including gloves, lab coat, and eye protection
Environmental Precautions: Avoid release into the environment, contain spill, prevent substances from entering watercourses, sewers, or soil
Spill Cleanup Methods: Absorb liquid with inert material, collect in appropriate containers for disposal, decontaminate area with soap and plenty of water
Disposal: Refer to waste disposal guidelines for hazardous chemicals, do not discharge into drains
Other Precautions: Provide adequate ventilation during clean-up
Precautions for Safe Handling: Wear appropriate PPE, avoid inhaling dust or vapors, avoid contact with eyes, skin, and clothing
Advice on Preventing Exposure: Use in chemical fume hood, handle in well-ventilated area
Safe Storage Requirements: Store in original container, tightly closed, protected from light and moisture, temperature-controlled facility (usually below 25°C)
Incompatibilities: Store away from strong oxidizing agents, acids, and sources of ignition
Other Storage Requirements: Clearly label containers, keep away from food and drink
Occupational Exposure Limits: No established limits for stibogluconate sodique, control exposure as for antimony compounds (OSHA PEL for antimony: 0.5 mg/m³ TWA)
Engineering Controls: Use local exhaust ventilation, safety enclosures
Personal Protective Equipment: Chemical-resistant gloves, protective eyewear, lab coat
Respiratory Protection: Use NIOSH-approved respirators if exposure risk exists outside of normal laboratory usage
Hygiene Measures: Wash hands after handling, do not eat, drink, or smoke in work areas, remove contaminated clothing promptly
Appearance: Clear, colorless to slightly yellow aqueous solution
Odor: Odorless
pH: Typically between 6.5 and 7.5
Boiling Point: Above 100°C (solution form)
Melting Point: Not determined for solution
Solubility: Completely soluble in water
Vapor Pressure: Not applicable (aqueous solution)
Relative Density: Approx. 1.0 g/cm³ (solution form)
Flash Point: Not flammable
Partition Coefficient (n-octanol/water): Not determined
Additional Properties: Stable under recommended storage and handling conditions
Chemical Stability: Stable under recommended storage, may degrade or precipitate out of solution in presence of excessive heat, light, or incompatible substances
Reactivity: Little reactivity under standard conditions, but reacts with strong acids and oxidizers
Hazardous Decomposition Products: May produce antimony oxides, sodium oxides, and carbon oxides during thermal decomposition
Conditions to Avoid: Excessive heat, strong sunlight, contaminant exposure, incompatibles
Incompatible Materials: Strong oxidizing agents, acids
Polymerization: Does not occur
Acute Toxicity: Harmful if ingested or absorbed through skin; typical LD50 values for sodium stibogluconate above 200 mg/kg (rat, intravenous)
Inhalation: May cause respiratory tract irritation, coughing, shortness of breath
Skin Corrosion/Irritation: Can cause moderate skin irritation upon contact
Eye Damage/Irritation: May cause eye irritation or conjunctivitis
Chronic Toxicity: Prolonged exposure may affect liver, kidney, and heart; notable risk of ECG changes with therapeutic doses
Carcinogenicity: No data suggesting carcinogenic risk in humans, classified as non-carcinogenic
Mutagenicity: Not found mutagenic in microbial assays
Reproductive Toxicity: High doses in animals associated with reproductive toxicity
Target Organs: Liver, kidney, heart
Clinical Symptoms: Nausea, vomiting, muscle pain, dizziness, abnormal liver function
Environmental Toxicity: Antimony compounds are toxic to aquatic organisms
Persistence and Degradability: Not readily biodegradable, may persist in environment
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms
Mobility in Soil: Expected to have moderate mobility due to solubility
Aquatic Fate: Can contribute antimony ions to water, posing risk to fish and aquatic invertebrates
Other Adverse Effects: Spillage into environment must be prevented, hazardous material for aquatic life
Waste Treatment Methods: Treat as hazardous chemical waste, incinerate or landfill in accordance with local, regional, and national regulations
Contaminated Packaging: Dispose of in the same way as unused product
Precautions: Do not release into drains or waterways, prevent contamination of soil and water table
EPA Waste Code: U-listed waste, specific for antimony and related compounds
Special Instructions: Consult disposal contractor for licensed facilities
UN Number: Not classified for transport under UN recommendations
Proper Shipping Name: Not regulated as a hazardous material in small quantities
Hazard Class: Not classified
Packing Group: Not assigned
Transport Labels: None required for standard pharmaceutical solutions
Other Transport Information: Secure packaging, avoid temperature extremes in transit
International Transport: Check regulations for air, sea, and road regarding pharmaceuticals containing antimonial compounds
U.S. Regulations (TSCA, SARA): Sodium stibogluconate not listed on TSCA, SARA Title III not specific for this compound but may apply to antimony compounds
European Regulations (REACH, CLP): Considered a medicinal product, largely exempt but general chemical safety rules apply
Canada (WHMIS): Controlled product, subject to occupational health and safety regulations
Australia (AICS): Not specifically listed, subject to state-level safety regulations
Other Regulatory Info: Pharmaceutical laws apply for finished dosages, workplace safety and environmental protection guidance always recommended
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