Product Name: Sodium Stibogluconate
Chemical Formula: C12H21NaO16Sb
Synonyms: Pentostam, Sodium antimoniogluconate
Manufacturer/Supplier: Local health authority or pharmaceutical supplier details
Recommended Use: Treatment for leishmaniasis
Contact Details for Emergency: Emergency response phone number, poison control center information, manufacturer contact information
CAS Number: 15451-10-2
UN Number: Consult latest transport regulations
Relevant Identified Uses: Medication for tropical disease management; not intended for general consumer applications
Classification: Toxic if swallowed, Hazardous for aquatic environment, Irritant to eyes and skin, Target organ toxicity
Physical Hazards: Not flammable or explosive, but forms toxic and corrosive smoke when burning
Primary Hazards: Harmful by ingestion, may cause skin and serious eye irritation, may cause organ damage from repeated exposure
Warning Symbols: Skull and crossbones (Toxic), Exclamation mark (Irritant), Aquatic hazard symbol
Signal Word: Danger
Potential Health Effects: Nausea, vomiting, muscle pain, heart rhythm disturbances, contact dermatitis, eye damage
Environmental Effects: Dangerous to aquatic life at high concentrations; long-term effects possible on aquatic environments
Main Ingredient: Sodium Stibogluconate
Concentration: Typically supplied as a 100 mg/mL solution
Purity: Pharmaceutical grade
Impurities: Minimal, related to the manufacturing process
Other Components: Water for injection, buffering agents such as sodium bicarbonate or sodium hydroxide; excipients vary by manufacturer
Hazardous Components: Antimony in pentavalent form, not present as an independent element
Formula Weight: 692.03 g/mol
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical help if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with soap and water, if irritation occurs get medical advice
Eye Contact: Rinse eyes with plenty of water for at least 10 minutes, remove contact lenses, seek medical attention if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, immediately contact poison control center or medical professionals
Most Important Symptoms: Gastrointestinal upset, chemical burns, dizziness, irregular heartbeat
Immediate Medical Attention: Required for significant exposure, especially by ingestion or if severe symptoms develop
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: None known under normal storage conditions
Specific Hazards: Emits toxic and corrosive gases under fire conditions (antimony oxides, sodium oxides, carbon oxides)
Special Protective Equipment: Full protective gear, self-contained breathing apparatus
Advice for Firefighters: Avoid inhaling vapors or combustion products, contain contaminated water used for extinguishing
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, antimony oxides, irritating fumes
Explosion Hazards: Not explosive, but heating may cause pressurized containers to burst
Personal Precautions: Wear protective gloves, clothing, and eye/face protection; avoid breathing dust, vapors, or mist
Environmental Precautions: Prevent entry into waterways, drains, or soil; contain to avoid contamination
Methods for Cleaning Up: Absorb spills with inert material (sand, vermiculite), collect in suitable closed containers for disposal
Decontamination: Clean spill area with plenty of water after removal of product
Disposal: Dispose of contaminated material using licensed hazardous waste services
Notification: Notify relevant authorities in case of significant environmental release
Handling: Use only in well-ventilated areas, avoid skin and eye contact, avoid ingestion, practice good industrial hygiene
Precautions: Do not eat, drink, or smoke near the product, use proper techniques to avoid splashes
Special Handling Instructions: Keep container tightly closed and properly labeled; use secondary containment for large quantities
Storage Conditions: Store at 15-25°C, protect from light, heat, and moisture
Segregation: Keep away from incompatible substances like acids, oxidizing agents
Container Materials: Store in original or chemically compatible, well-sealed containers
Duration: Follow expiry date and guidelines from manufacturer for storage period
Engineering Controls: Work in fume hood or with local exhaust ventilation for large-scale use
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), splash goggles, protective lab coats, respiratory protection if atmospheric concentrations rise
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing immediately, do not take contaminated garments home
Exposure Limits: Occupational Exposure Limit for antimony compounds: 0.5 mg/m³ TWA (as antimony, ACGIH guideline)
Monitoring: Environmental and biological monitoring recommended for regular handlers
Environmental Protection: Use safeguards to prevent product entering drains or the environment
Appearance: Clear, colorless to pale yellow solution
Odor: Odorless
Boiling Point: Approximately 100°C (aqueous solution)
Melting Point: Not applicable (liquid)
pH: 6.0-7.5 (solution)
Solubility: Freely soluble in water, slight solubility in ethanol
Vapor Pressure: Similar to water, negligible at room temperature
Density: 1.05-1.15 g/cm³ (depending on concentration)
Viscosity: Comparable to water
Flash Point: Not combustible
Partition Coefficient (Log Kow): Not available
Decomposition Temperature: Not specified
Other Data: Forms poorly defined crystals in dry form; stable in aqueous solution
Chemical Stability: Stable under normal recommended storage and handling conditions
Stability: Decomposes under extreme temperatures, exposure to strong acids, or oxidizers
Reactivity: Reactive with acids, oxidizing agents; releases toxic gases if heated or mixed improperly
Hazardous Reactions: Contact with incompatible materials can produce potentially hazardous conditions
Polymerization: Not expected
Conditions to Avoid: Heat, direct sunlight, humidity, extremes of pH
Incompatible Materials: Strong acids, strong oxidizers, reducing agents
Acute Toxicity: Oral LD50 data (animal): 200-500 mg/kg (mouse, as antimony compound); can cause nausea, vomiting, cardiac issues
Chronic Toxicity: Prolonged exposure may result in liver and kidney dysfunction, cardiotoxicity
Routes of Exposure: Inhalation, dermal, ocular, ingestion
Symptoms: Abdominal pain, diarrhea, skin rashes, electrocardiogram changes, headache, dizziness
Carcinogenicity: Antimony compounds classified as possible human carcinogens by IARC (Group 2B)
Mutagenicity: Data limited; not expected to be strongly mutagenic
Developmental/Reproductive Toxicity: High doses in animal studies linked to potential teratogenic effects, data in humans limited
Medical Conditions Aggravated: Pre-existing cardiac, hepatic, or renal disorders may worsen with exposure
Target Organs: Heart, liver, kidneys
Ecotoxicity: Toxic to fish, aquatic invertebrates; antimony and its salts are persistent and bioaccumulative
Aquatic Effects: LC50 (96h, fish): 34 mg/L (antimony-based), sub-lethal toxic effects evident at lower levels
Persistence: Does not degrade quickly; antimony ions remain mobile in water
Bioaccumulation: Potential for slow bioaccumulation, especially in aquatic organisms
Soil Mobility: Antimony salts move readily in moist soils, may leach into groundwater
Degradability: Not readily biodegradable, does not undergo significant photodegradation
Special Precautions: Minimize environmental release; avoid flushing into sewer or waterways
Waste Disposal: Treat as hazardous pharmaceutical waste; collect and remove through certified hazardous waste contractor
Special Handling: Keep in original, sealed containers until disposal; do not mix with general waste or allow product to dry out in open air
Disposal of Containers: Decontaminate empty containers via autoclaving or incineration, follow local regulations
Regulatory Compliance: Must comply with country and local hazardous waste rules (RCRA, EU Directive 2008/98/EC, etc.)
Environmental Precautions: Never dispose into watercourses, sewers, or open land
UN Number: 2811 (Toxic solid, organic, n.o.s., including sodium stibogluconate)
Proper Shipping Name: Toxic solid, organic, n.o.s.
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labeling Requirements: Toxic, environmentally hazardous labels
Special Precautions: Protect from physical damage and moisture during transport; avoid releasing to environment
Other Requirements: Keep packaging intact, use durable containers as advised by local or international transport authorities
Additional Information: Check applicable air, rail, road, and sea freight rules for updates
Labeling: Classified as hazardous under global harmonized system (GHS), subject to strict labeling
International Inventories: Registered on pharmaceutical or chemical substance inventories (including ECHA REACH, US TSCA where applicable)
OSHA Status: Hazardous chemical under OSHA Hazard Communication Standard
SARA Title III Information: May trigger reporting based on antimony content
RCRA Status: Hazardous waste (antimony compounds)
Directive Compliance: Meets European Dangerous Substance Directive and CLP standards; follows strict pharmacovigilance guidelines for medicines
Other Requirements: Subject to restrictions of use, handling, and disposal as a prescription drug; medical professionals and authorized handlers only
Worker Safety: Safety training, personal protective equipment, record-keeping for workplace exposure, health surveillance recommended
Providing high-quality chemical products and logistics solutions for global trade partners.
