Product Name: Sodium Antimonylgluconate
Chemical Formula: C6H11NaO7Sb
Synonyms: Stibogluconate Sodium, Sodium Stibogluconate
CAS Number: 18421-51-1
Recommended Use: Antimonial compound, commonly used for the treatment of leishmaniasis.
Supplier: Pharmaceutical laboratories, research suppliers.
Contact Details: Reference manufacturer-specific contact and emergency numbers provided on packaging or invoice documents for incident response and consultation.
Classification: Harmful if swallowed, suspected of causing cancer, toxic to aquatic life with long lasting effects.
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed. H351: Suspected of causing cancer. H410: Very toxic to aquatic life with long lasting effects.
Pictograms: Exclamation mark, Health hazard, Dead fish/tree symbol.
Precautionary Statements: Wash hands thoroughly after handling. Do not eat, drink or smoke during use. Avoid release to the environment.
Routes of Exposure: Inhalation, ingestion, skin and eyes.
Symptoms: Nausea, vomiting, diarrhea, headache, muscle pain, skin irritation. Chronic effects include potential kidney or liver issues.
Component: Sodium Antimonylgluconate
Concentration: 98-100%
Chemical Formula: C6H11NaO7Sb
CAS Number: 18421-51-1
Impurities: Trace antimony salts, possible sodium salts.
Inhalation: Move person to fresh air. Seek immediate medical help. Provide artificial respiration if breathing stops.
Skin Contact: Remove contaminated clothing and shoes. Wash affected skin with plenty of soap and running water. Seek medical attention for persistent irritation.
Eye Contact: Rinse carefully with water for at least 15 minutes. Remove contact lenses if present and easy to do. Continue rinsing and get medical advice.
Ingestion: Do not induce vomiting. Rinse mouth with water. Drink water if conscious but avoid giving anything by mouth to an unconscious person. Get urgent medical care.
Most Important Symptoms: Nausea, vomiting, headache, muscle cramping, possible kidney/liver effects with repeated exposure.
Immediate Medical Attention: Strongly advised for significant exposure or if symptoms develop. Monitor for respiratory distress, arrhythmias, and electrolyte imbalance.
Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical powder, or carbon dioxide. Water spray may help cool containers and disperse vapors but avoid water jet.
Specific Hazards: Emits antimony oxides and sodium oxides on decomposition. May produce toxic fumes in a fire.
Protective Equipment and Precautions: Wear full firefighting gear including self-contained breathing apparatus. Approach fire from upwind to avoid hazardous fumes.
Firefighting Instructions: Remove containers from fire area if possible without risk. Cool containers exposed to flames with water spray. Contain runoff to prevent environmental contamination.
Personal Precautions: Wear appropriate protective gear, including gloves, goggles, and lab coat. Evacuate non-essential personnel from the area.
Environmental Precautions: Avoid direct release into drains, surface, or groundwater. Use barriers to prevent material from entering sewers or confined spaces.
Clean-Up Methods: Collect spillage without generating dust using non-sparking tools. Absorb with inert material (sand, vermiculite) and transfer to a labeled waste container.
Decontamination: Wash spill area with large amounts of water after removal of bulk material. Dispose of cleaning materials in accordance with local regulations.
Handling: Use in well-ventilated areas. Avoid contact with skin, eyes, and clothing. Do not breathe dust or vapors. Practice good hygiene.
Storage: Store in tightly closed containers, out of direct sunlight, in a cool, dry, well-ventilated area. Separate from incompatible materials such as strong acids or bases.
Safe Transfer: Use secondary containment to prevent spills. Keep containers upright and secure during transport.
Special Requirements: Clearly label storage areas. Limit access to authorized personnel only.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat. Use a NIOSH-approved respirator if exposure limits may be exceeded.
Engineering Controls: Local exhaust ventilation or fume hood recommended for all handling operations. Maintain eyewash stations and safety showers near work areas.
Exposure Limits: Antimony compounds (OSHA PEL: 0.5 mg/m³, ACGIH TLV: 0.5 mg/m³ as Sb).
Environmental Controls: Prevent release into the environment using containment and proper waste management.
Hygiene Measures: Wash hands thoroughly after any handling. Remove and wash contaminated clothing before reuse.
Appearance: White to off-white crystalline powder.
Odor: Odorless.
Odor Threshold: Not applicable.
pH: 7.5 - 8.5 (in 1% aqueous solution).
Melting Point/Freezing Point: Decomposes before melting.
Boiling Point: Not available.
Flash Point: Not flammable.
Evaporation Rate: Not applicable.
Flammability: Not considered flammable.
Vapor Pressure: Negligible at room temperature.
Vapor Density: Not available.
Relative Density: 1.8 – 2.0 g/cm³
Solubility: Soluble in water.
Partition Coefficient (n-octanol/water): Not determined.
Auto-ignition Temperature: Not applicable.
Decomposition Temperature: May decompose on heating above 200°C.
Viscosity: Not applicable.
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Not highly reactive with most substances under normal storage and handling conditions.
Possibility of Hazardous Reactions: Reacts with strong acids and bases, producing toxic gases.
Conditions to Avoid: Excessive heat, moisture, direct sunlight.
Incompatible Materials: Strong oxidizers, acids, bases.
Hazardous Decomposition Products: Antimony oxides, sodium oxides, carbon oxides.
Acute Toxicity: Harmful if swallowed. Oral LD50 (rat): Data not widely available but estimated to be in the low hundreds mg/kg. Can cause gastrointestinal upset and organ toxicity.
Chronic Toxicity: Long-term or repeated exposure may result in damage to liver and kidneys. Reports of bone marrow suppression and antimony-related cardiovascular effects exist in animal studies.
Likely Routes of Exposure: Ingestion, inhalation, skin, and eye contact.
Symptoms: Abdominal cramps, diarrhea, vomiting, headache, dizziness, skin rash, tremors. Serious exposure can lead to systemic antimony poisoning.
Carcinogenicity: IARC classifies antimony trioxide as possibly carcinogenic (Group 2B). No classification by NTP or OSHA for this specific compound but caution warranted.
Mutagenicity: Data limited, but antimony compounds may have potential genotoxic effects.
Other Effects: Potential for allergic skin or respiratory reaction. Prolonged exposure may damage the myocardium and nervous system.
Ecotoxicity: Highly toxic to aquatic life. Can accumulate in water and sediments, potentially impacting fish and invertebrates.
Persistence and Degradability: Not rapidly biodegradable. Remains in environment for extended periods.
Bioaccumulative Potential: Antimony compounds may accumulate in aquatic organisms.
Mobility in Soil: Moderate mobility; soluble in water, can migrate through soil into groundwater.
Other Adverse Effects: Toxic to microorganisms. Avoid discharge into environment to limit spread and bioaccumulation.
Waste Treatment Methods: Collect and contain waste in sealed, labeled containers suitable for hazardous waste disposal.
Disposal Methods: Follow all local, regional, national, and international guidelines for chemical waste. Incineration or treatment in a permitted hazardous waste facility preferred. Do not pour chemicals down the drain or release into the environment.
Contaminated Packaging: Decontaminate containers before disposal, or dispose as hazardous waste.
Special Precautions: Handle waste only with appropriate PPE. Store away from incompatible materials prior to disposal pick-up.
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (Sodium antimonylgluconate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels Required: Poison (skull and crossbones symbol), environmental hazard symbol as appropriate.
Special Precautions for Transport: Prevent packaging damage, keep container tightly closed. Clearly label for emergency responders. Ensure driver trained for hazardous materials as specified by DOT, ADR, IATA/ICAO, IMDG regulations.
Environmental Hazards: Marine pollutant. Avoid release to the environment during transport.
OSHA Status: Regulated as a hazardous chemical under OSHA Hazard Communication Standard.
TSCA Status: Listed.
SARA Title III: Reportable as an Extremely Hazardous Substance under Section 313 due to antimony content.
RCRA Status: Waste may be classified as hazardous under U.S. regulations.
Clean Water Act / Clean Air Act: Antimony compounds are regulated as priority pollutants.
International Inventories: Listed on most chemical inventories including EINECS, DSL, AICS, ENCS.
Other Regulations: Subject to workplace right-to-know regulations. Consult local authorities for additional or special requirements.
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