Product Name: Sodium antimonylgluconate
Synonyms: Sodium stibogluconate, Stibogluconate sodium
Chemical Formula: C12H21Na2O16Sb
CAS Number: 154-64-5
Recommended Use: Treatment of leishmaniasis, research, pharmaceutical manufacturing
Supplier Details: Manufacturer and supplier names, business addresses, emergency contact numbers. Prioritize clear contact info for emergencies and procurement verification.
GHS Classification: Acute toxicity (oral, dermal, inhalation) Category 3; Skin and eye irritation Category 2; Carcinogenicity Category 2.
Pictograms: Skull and crossbones, exclamation mark, health hazard symbols.
Signal Word: Danger
Hazard Statements: Harmful if swallowed, toxic in contact with skin or if inhaled; causes skin and eye irritation; suspected of causing cancer.
Precautionary Statements: Avoid contact with skin, eyes, and clothing; use personal protective equipment; do not eat, drink, or smoke during handling.
Chemical Name: Sodium antimonylgluconate
Concentration: Typically supplied as a pure or high-purity compound (>98%)
CAS Number: 154-64-5
REACH Registration Number: Not widely registered under REACH
Other Ingredients: None identified in pharmaceutical grade samples; impurities traceable by supplier’s certificate of analysis.
Inhalation: Move individual to fresh air. Keep at rest. Seek medical attention for symptoms like trouble breathing, coughing, or weakness.
Skin Contact: Immediately remove contaminated clothing, rinse skin with plenty of water. Use soap if available. Get medical help if irritation develops or persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes, removing contact lenses if present and easy to do. Continue rinsing if discomfort continues. Contact an ophthalmologist.
Ingestion: Rinse mouth, do not induce vomiting unless instructed by medical personnel. Seek emergency care immediately, as antimony compounds can be acutely toxic.
Most Important Symptoms: Nausea, vomiting, cramps, chest pain, shortness of breath, burning sensation, allergic reactions.
Notes for Doctors: Symptomatic treatment and supportive measures recommended. Monitor electrolytes, cardiovascular, and renal function.
Suitable Extinguishing Media: Use water spray, foam, dry powder, carbon dioxide.
Unsuitable Extinguishing Media: Do not use high-powered water jet, since splatter or spread of contamination may occur.
Specific Hazards: Toxic fumes of antimony oxides, sodium oxides, and carbon oxides may develop.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing.
Fire and Explosion Precautions: Remove containers from fire area if safe to do so. Prevent extinguishing water runoff from contaminating sewers or waterways.
Personal Precautions: Don personal protective equipment including gloves, goggles, and appropriate respirators; avoid creating dust.
Environmental Precautions: Do not allow material to enter drains, sewers, or watercourses. Notify environmental authorities if a significant spill occurs.
Containment and Clean-up: Spills should be absorbed with inert material such as dry sand or earth followed by disposal in chemical waste containers. Ventilate area and wash spill site thoroughly after removal.
Decontamination Recommendations: Use water and detergent solutions for hard surfaces. Collect waste generated from spill clean-up in sealed containers.
Precautions for Handling: Wear protective equipment to reduce exposure to skin, eyes, and respiratory tract. Handle in a well-ventilated area; avoid dust generation.
Conditions for Safe Storage: Store in tightly closed original container in a cool, dry place protected from light and moisture. Keep away from incompatible materials such as acids, strong oxidizers, and reducing agents.
Storage Temperature: Typically store at 2–8°C; consult specific manufacturer’s guidelines for stability.
Special Instructions: Ensure secure storage to protect against theft or misuse given the compound’s toxic properties. Isolate from food and beverages.
Occupational Exposure Limits: No specific limit set for sodium antimonylgluconate; reference ACGIH TLV for antimony: 0.5 mg/m³ TWA.
Engineering Controls: Employ local exhaust or general ventilation to maintain airborne concentrations below threshold limits.
Personal Protective Equipment: Use chemical-resistant gloves, splash goggles, lab coat, and approved respirator for dust.
Hygiene Measures: Wash hands thoroughly after handling and before eating, drinking, or smoking. Do not reuse contaminated clothing until professionally cleaned.
Appearance: White to off-white crystalline solid or powder.
Odor: Odorless
Molecular Weight: 626.87 g/mol
Melting Point: Decomposition occurs before melting
Solubility: Readily soluble in water, slightly soluble in ethanol
pH (1% solution): Approximately 6–8
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not established
Flash Point: Not flammable
Partition Coefficient (n-octanol/water): Not available
Chemical Stability: Stable under recommended storage and handling conditions.
Reactivity: Avoid exposure to heat, acids, strong oxidizers, and reducing agents.
Hazardous Decomposition Products: May release antimony oxides, sodium oxides, carbon oxides when heated to decomposition.
Possibility of Hazardous Reactions: Not known under normal processing.
Incompatible Materials: Strong acids, reducing agents, and oxidizing agents.
Acute Toxicity: Oral LD50 for rats is estimated at < 40 mg/kg (antimony compounds); human data limited but acute toxicity is significant.
Routes of Exposure: Inhalation, oral, dermal, ocular
Symptoms: Nausea, vomiting, metallic taste, cardiac disturbances, renal effects, headaches.
Chronic Effects: Prolonged exposure may result in liver and kidney damage, antimony pneumoconiosis, gastrointestinal disturbances.
Sensitization: May cause allergic skin reaction.
Carcinogenicity: Classified by IARC as possibly carcinogenic to humans (Group 2B, antimony compounds).
Mutagenicity/Teratogenicity: Data insufficient, caution recommended in pregnant or breastfeeding individuals.
Ecotoxicity: Antimony compounds can be toxic to aquatic organisms at low concentrations.
Persistence and Degradability: Not readily biodegradable; antimony persists in the environment and may bioaccumulate.
Mobility in Soil: Moderate mobility; may contaminate groundwater.
Other Adverse Effects: No ozone depletion or endocrine disruption data available. Monitoring environmental release helps reduce risks to wildlife.
Waste Treatment Methods: Dispose of as hazardous chemical waste according to federal, state, and local environmental regulations.
Disposal Containers: Use tightly sealed containers labeled with chemical contents and hazards.
Contaminated Packaging: Treat as chemical waste and follow the same disposal protocol.
Additional Notes: Do not mix with household refuse. Coordination with licensed hazardous waste disposal contractors is required.
UN Number: Not classified with a specific UN number for road, sea, or air transport but treat as toxic solid, organic.
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains sodium antimonylgluconate)
Hazard Class: 6.1 (toxic substances)
Packing Group: III
Transport Labels: Toxic, consult with courier about further marking requirements.
Special Transport Precautions: Ship sealed, provide clear documentation, alert carriers to toxic properties.
TSCA Status: Listed for research and clinical use in the United States.
EPA Status: Subject to antimony and its compounds reporting under EPCRA and CERCLA.
OSHA: Regulated under Hazard Communication Standard; SDS must be available.
EU Directive Compliance: Subject to REACH restrictions on antimony compounds.
Other International Regulation: Check with local and national regulations regarding import, use, and disposal. Always reference agency guidance to minimize risks, ensure compliance, and guarantee safe handling.
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