Product Name: (S)-(E)-2-[3-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]-Phenyl]-2-Propanol
Chemical Formula: C28H24ClNO2
Chemical Family: Quinoline derivatives
Recommended Use: Research, pharmaceutical intermediate
Supplier: [Specify company or laboratory with address and contact information]
Emergency Contact: [Specify emergency phone number and contact email]
Synonyms: [List any known synonyms, research names, or project codes]
Classification: Acute toxicity (oral, dermal), Skin sensitization, Hazardous to aquatic environment
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Harmful if in contact with skin. May cause skin irritation. Suspected of causing genetic defects. May damage fertility. Toxic to aquatic life with long lasting effects.
Precautionary Statements: Avoid breathing dust or vapors. Wash hands thoroughly after handling. Wear protective gloves/eye protection/face protection. Do not eat, drink, or smoke when using product. Avoid release to environment.
GHS Label Elements: Exclamation mark, Health hazard, Environment symbol
Other Hazards: Possible irritant to eyes and respiratory tract. Chronic effects have not been fully studied.
Chemical Identity: (S)-(E)-2-[3-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-3-Hydroxypropyl]-Phenyl]-2-Propanol
CAS Number: [Provide if available]
Concentration (%): ≥98% pure
Impurities: Minor proprietary synthetic by-products may be present at <1% levels, none classified as hazardous under GHS.
Additives: No additives used.
Inhalation: Remove affected person to fresh air. If breathing is difficult, provide oxygen. Seek immediate medical attention for persistent symptoms like coughing, chest tightness, or shortness of breath.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Seek medical attention if irritation or reaction develops.
Eye Contact: Flush eyes with plenty of water for a minimum of 15 minutes, occasionally lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Get medical attention if redness, pain, or vision changes occur.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Seek immediate medical assistance, bringing MSDS if possible.
Most Important Symptoms and Effects: Local irritation, nausea, headache, possible allergic reaction.
Notes for Medical Personnel: Treat symptomatically. Monitor respiratory and allergic responses.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, or foam. Avoid high pressure water streams which may spread material.
Unsuitable Extinguishing Media: High-pressure water jet.
Specific Hazards Arising from Chemical: May emit toxic fumes of chlorine, nitrogen oxides, carbon monoxide, and carbon dioxide under fire conditions.
Protective Equipment: Self-contained breathing apparatus (SCBA) and full protective gear for firefighters.
Special Procedures: Cool exposed containers with water. Dike fire-control water to prevent contamination of environment.
Personal Precautions: Wear protective equipment including gloves, goggles, lab coat, and, for large spills, a suitable respirator. Ventilate area. Avoid generating dust.
Environmental Precautions: Prevent further leakage or spillage if safe. Do not discharge to drains or natural water bodies. Report spills to environmental authorities as required.
Methods for Cleanup: Collect spilled material with inert absorbent (vermiculite, sand). Pick up and place in suitable, labeled containers for disposal. Clean affected surface thoroughly with water and detergent. Dispose according to local and national regulations.
Precautions for Safe Handling: Minimize contact with skin, eyes, and clothing. Use in a well-ventilated area or fume hood. Do not eat, drink, or smoke in areas of chemical use. Wash hands after handling.
Storage Conditions: Store in tightly closed original container in a cool, dry, well-ventilated place. Protect from light, moisture, and incompatible materials. Keep away from foodstuffs and beverages.
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases. Avoid alkali metals and reducing agents.
Safe Packaging Materials: Amber glass or high-density polyethylene (HDPE) containers with secure cap. Secondary containment recommended for bulk quantities.
Occupational Exposure Limits: No established limits for compound; minimize exposure by engineering and administrative controls.
Engineering Controls: Work in chemical fume hood. Use local exhaust to control airborne concentrations. Provide eyewash stations and safety showers in work area.
Personal Protective Equipment:
Appearance: Off-white crystalline powder or solid
Odor: Very faint, slightly aromatic
Odor Threshold: Not established
pH: Not applicable (insoluble in water)
Melting Point: 158–162°C (literature/empirical)
Boiling Point: Decomposes before boiling
Flash Point: Not determined, presumed above 150°C
Evaporation Rate: Not measured
Flammability: Non-flammable solid, not easily ignited
Vapor Pressure: Not measurable at room temperature
Vapor Density: Not determined
Relative Density: 1.33–1.38 (calculated)
Solubility: Slightly soluble in ethanol, methanol, DMSO; insoluble in water
Partition Coefficient (log Kow): Expected moderate hydrophobicity
Auto-Ignition Temperature: Not established
Decomposition Temperature: 280°C (approximate from decomposition data)
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage conditions. Degradation may occur with light, heat, or exposure to air.
Reactivity: Low, avoids strong acids and oxidizers.
Hazardous Reactions: No known hazardous polymerization
Conditions to Avoid: Direct sunlight, moisture, excessive heat, and open flames
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Hydrogen chloride, quinoline-related breakdown products, carbon monoxide, and carbon dioxide
Likely Routes of Exposure: Inhalation, dermal, oral
Acute Toxicity: May cause irritation of mouth, throat, and stomach if ingested in large amounts. Inhalation of dust can lead to nose and respiratory tract irritation.
Skin Corrosion/Irritation: May cause redness or discomfort on prolonged contact.
Serious Eye Damage/Irritation: Dust or fragments may cause mechanical and chemical irritation if exposed to eyes.
Respiratory or Skin Sensitization: Rarely causes sensitization, but allergic reactions cannot be excluded.
Germ Cell Mutagenicity: Structure suggests potential genetic toxicity; adequate empirical data not available.
Carcinogenicity: No data available for long-term animal studies. Not listed as carcinogen by NTP, IARC, or OSHA.
Reproductive Toxicity: Components may pose risk for adverse reproductive effects due to quinoline core.
STOT-Single Exposure: Data insufficient for assessment
STOT-Repeated Exposure: Chronic exposure studies not completed
Aspiration Hazard: Not predicted for this solid compound
Other Symptoms: Possible allergic skin reaction, headache, or mild nausea following exposure.
Ecotoxicity: Hazardous to aquatic organisms even at low concentrations. Do not allow to reach ground water, water bodies, or sewage system.
Persistence and Degradability: Expected to degrade slowly in the environment due to aromatic and quinoline structures.
Bioaccumulative Potential: Moderate, based on chemical structure and log Kow
Mobility in Soil: Low mobility, not expected to leach rapidly
Other Adverse Effects: No data on disruption of soil or water microorganisms; precaution advised due to toxicity.
Waste Treatment Methods: Dispose through licensed hazardous waste contractor in compliance with local and national regulations.
Product Disposal: Do not mix with household or general waste. Dispose as chemical waste, incineration preferred if compliant with local policies.
Contaminated Packaging: Rinse with suitable solvent, treat rinsate as hazardous. Ensure all labeling is removed or defaced before recycling or disposal.
Environmental Precautions: Prevent release to environment by sealing containers and managing residues.
UN Number: Not assigned for this substance
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (contains quinoline, chloro compound derivative)
Transport Hazard Class: 9 (if regulated in certain countries); not regulated under US DOT for research quantities, but check local law
Packing Group: III (for hazardous substances)
Environmental Hazards: Yes, marine pollutant
Special Precautions: Avoid environmental release during shipping. Ensure containers are well sealed and labeled.
US TSCA (Toxic Substances Control Act): Not listed for commercial manufacture; research use only permitted.
OSHA Hazards: Irritant, reproductive toxin, environmental hazard
EU REACH: Not registered under REACH; use limited to approved research facilities
WHMIS (Canada): Classified as toxic, environmental hazard
SARA Title III: Not listed under Extremely Hazardous Substances; reportable quantity set by local jurisdiction
California Proposition 65: Not specifically listed, but similar quinoline derivatives have been flagged for potential toxicity
Other National/International Regulation: User must ensure compliance with relevant regulations in country of use, including handling, transport, and disposal
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