Product Name: (S)-Chloro-1,2-Propanediol
Synonyms: (S)-Epichlorohydrin diol, (S)-2-Chloro-1,2-propanediol, (S)-CPD
CAS Number: 3964-18-9
Molecular Formula: C3H7ClO2
Molecular Weight: 110.54 g/mol
Recommended Use: Laboratory chemicals, chemical synthesis, specialty chemistry
Manufacturer/Supplier: Information available on request
Emergency Contact: Local emergency number or poison control center
Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin irritation, Specific target organ toxicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, contact causes skin and eye irritation, exposure may damage organs
Pictogram: Skull and crossbones, exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust or vapor, wash thoroughly after handling, do not eat, drink or smoke when using, wear protective clothing, gloves, and eye or face protection
Other Hazards: May produce hazardous decomposition products on burning, vapors may cause respiratory tract irritation
Chemical Name: (S)-Chloro-1,2-Propanediol
CAS Number: 3964-18-9
Concentration: ≥98%
Impurities: Trace related compounds or byproducts possible in low percentages, non-significant to main hazards
Inhalation: Move person to fresh air, keep at rest, seek medical advice if symptoms persist—cough, headache, dizziness
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, consult a doctor for irritation or burns
Eye Contact: Rinse with clean water for at least 15 minutes holding eyelids apart, seek immediate medical attention without delay
Ingestion: Rinse mouth, do not induce vomiting, get medical advice immediately, give water if conscious
Most Important Symptoms: Burning sensation, cough, headache, redness, nausea, drowsiness
Immediate Medical Attention: Needed for eye contact, prolonged exposure, suspected ingestion
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Media: High pressure water jets may spread product
Specific Hazards: Combustion releases hazardous gases including hydrogen chloride, carbon monoxide, phosgene, carbon dioxide
Special Firefighting Procedures: Wear self-contained breathing apparatus and full protective gear, prevent run-off to sewers or waterways
Hazardous Combustion Products: Hydrogen chloride gas, carbon oxides, phosgene, toxic fumes
Personal Precautions: Evacuate unnecessary personnel, wear suitable protective clothing, gloves, eye and face protection
Environmental Precautions: Avoid product release to soil, sewers, drains, or water sources
Methods for Cleaning Up: Absorb with inert materials like vermiculite or sand, gather into containers for disposal, ventilate affected area, wash site with water after material removal
Other Information: Prevent further leakage if safe to do so, remove all ignition sources
Handling: Use only with adequate ventilation, handle in closed systems if possible, avoid contact with skin, eyes, and clothing, prevent formation of vapors or aerosols, wash hands thoroughly after handling, keep containers tightly closed
Storage: Store in cool, well-ventilated area, keep container tightly sealed and upright, store away from incompatible materials such as strong bases, oxidizing agents, and acids, protect from moisture and direct sunlight, maintain temperature between 2°C and 8°C
Specific End Uses: Restricted to chemical synthesis and research applications by trained personnel
Control Parameters: No established limits for this compound, use good industrial hygiene practices
Engineering Controls: Work with a chemical fume hood or local exhaust, eyewash stations and safety showers should be accessible
Personal Protection: Chemical resistant gloves (nitrile rubber, neoprene), safety goggles or face shield, lab coat or apron, respiratory protection for inadequate ventilation
Hygiene Measures: Keep work areas clean, remove contaminated clothing and wash before reuse, do not eat or drink where chemical is used
Appearance: Colorless to pale yellow liquid
Odor: Faint, slightly sweet or pungent odor
Boiling Point: 132–134°C at 750 mmHg
Melting Point: Not well defined (liquid at room temperature)
Flash Point: Around 110°C (closed cup)
Evaporation Rate: Not available
Flammability: Not classified as highly flammable, but combustible under high heat
Vapor Pressure: Low at 20°C
Relative Density: About 1.29 g/cm³
Solubility: Miscible with water and many organic solvents
Partition Coefficient (log Kow): Not specified
Viscosity: Moderately viscous
Chemical Stability: Stable under standard conditions of storage and handling
Possibility of Hazardous Reactions: Reacts with strong acids, bases, oxidizing agents—may release toxic gases
Conditions to Avoid: Excessive heat, sparks, flames, sources of ignition, moisture, direct sunlight
Incompatible Materials: Strong oxidizers, strong acids, strong bases—danger of violent reaction or formation of toxic products
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, phosgene, chloroacetaldehyde
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity (Oral, LD50): Estimated rat oral LD50 150-300 mg/kg—shows significant toxicity on ingestion
Skin Corrosion/Irritation: Causes skin irritation, prolonged contact increases severity
Serious Eye Damage/Irritation: Causes serious eye irritation or burns
Respiratory Irritation: Vapors and aerosols can irritate mucous membranes and upper respiratory tract
Long-term Effects: Can cause damage to kidneys, liver, and possibly the nervous system with repeated exposure
Carcinogenicity: No data specific to (S)-chloro-1,2-propanediol found, but related compounds such as 1,3-dichloro-2-propanol are possible carcinogens
Other Information: Sensitization unlikely but not excluded
Toxicity to Aquatic Life: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Some biodegradability expected, but persistence depends on environmental conditions
Bioaccumulative Potential: Low to moderate, depends on specific hydrolysis rates and environmental parameters
Mobility in Soil: Highly mobile due to water solubility, risk of groundwater contamination
Other Adverse Effects: No data on ozone depletion, greenhouse gas potential, or endocrine disruption, but prudent to avoid uncontrolled release
Waste Treatment Methods: Dispose of contents and container by licensed chemical waste disposal contractor,
Product Disposal: Do not release into environment, do not pour down drain,
Contaminated Packaging: Empty containers retain product residue, handle as hazardous waste,
Legal Compliance: Disposal should meet all local, regional, national, and international regulations,
Other Disposal Recommendations: Incineration in suitable facility preferred
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. ((S)-Chloro-1,2-propanediol)
UN Number: UN2810
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labeling Requirements: Toxic
Environmental Hazards: Not classified as marine pollutant by default, but take precautions to avoid release
Special Precautions for User: Avoid transporting with food, feed, or clothing, secure packaging, observe hazardous material regulations
Other Transport Information: Follow ICAO/IATA (air), IMDG (sea), ADR/RID (rail/road) guidelines
Safety, Health and Environmental Regulations: Listed or regulated under chemical inventories such as EINECS/ELINCS (EU), TSCA (USA), DSL (Canada), compliant with REACH criteria in the EU
SARA Title III (Sections 302/304, 311/312, 313): Not listed under extremely hazardous or reportable quantities, but general hazard and reporting rules apply
OSHA Classification: Hazardous chemical as defined by the Occupational Safety and Health Administration regulations
Other Regulations: Workers must be trained according to chemical safety and hazardous materials regulation, chemical spills and exposures must be reported according to local laws, applies to laboratory and manufacturing settings
Additional Information: Consult applicable national, state, provincial, and local laws and regulations regarding safe use and disposal
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