Product Name: S-3-chloro-1,2-propanediol
CAS Number: 96-24-2
Synonyms: 3-Chloro-1,2-propanediol, α-monochlorohydrin, Monochlorohydrin
Recommended Use: Laboratory reagent, chemical intermediate
Supplier: Specify chemical supplier contact details
Emergency Contact: Access local poison control or emergency response phone
GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin irritant, Eye irritant, Carcinogenicity - suspected human carcinogen
Signal Word: Danger
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause cancer through repeated exposure, suspected of causing genetic defects
Pictograms: Skull and crossbones, exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust, mist, vapors, wear gloves/eye/face protection, wash thoroughly after handling, do not eat/drink/smoke while using product
Substance: S-3-chloro-1,2-propanediol
Chemical Formula: C3H7ClO2
Molecular Weight: 110.54 g/mol
Purity: Usually over 97% for laboratory or industrial use
Impurities: Details available upon supplier specification, possible trace levels of propanediol derivatives
HS Code: 2905.39.90 (for international transport purposes)
Inhalation: Move person to fresh air, keep at rest, seek immediate medical attention if symptoms develop such as coughing, shortness of breath or dizziness
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, wash with soap, obtain medical advice for irritation or burns
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present & easy, continue rinsing, get medical help if irritation persists
Ingestion: Rinse mouth thoroughly, never give anything by mouth to an unconscious person, do not induce vomiting, call poison center or doctor immediately
Suitable Extinguishing Media: Use CO2, dry chemical powder, or alcohol-resistant foam
Specific Hazards: May produce toxic fumes such as hydrogen chloride, phosgene, carbon monoxide, carbon dioxide when heated or burned
Protective Equipment: Firefighters use self-contained breathing apparatus, full protective clothing, fight fire from upwind to avoid hazardous vapors
Thermal Decomposition: Risk of releasing corrosive and toxic gases on combustion, ventilate area after fire is out, contaminated extinguishing water must be collected and disposed of safely
Personal Protection: Use chemical goggles, gloves, coveralls, and suitable respiratory protection
Environmental Precautions: Prevent further leakage or spillage if safe, avoid entering waterways, sewers, basements or confined areas, report releases as required by local authority
Cleanup Methods: Contain and collect spillage with non-combustible absorbent materials (sand, earth, vermiculite), place in chemical waste container for disposal, wash spill site afterwards making sure all residues are removed
Handling: Use in well-ventilated area, avoid contact with skin, eyes, and clothing, do not breathe vapors or mist, open containers carefully
Storage Conditions: Store at temperatures between 2–8°C, out of direct sunlight, in tightly closed original container, segregate from oxidizers, acids, bases
Special Requirements: Use only non-sparking tools, keep away from food and drink, provide spill containment and emergency wash stations nearby
Exposure Limits: No established OSHA or ACGIH limits, use workplace monitoring to minimize exposure, follow local guidelines
Engineering Controls: Local exhaust ventilation, general ventilation in workspace
Personal Protective Equipment (PPE): Chemical-resistant gloves (butyl rubber, nitrile), tightly fitting safety goggles, lab coats, face shield if splashing is likely, use proper respirators during high vapor or spill situations
Hygiene Measures: Do not eat or drink in work area, wash hands thoroughly before breaks and after handling product, change contaminated clothing
Appearance: Colorless to pale yellow viscous liquid
Odor: Mild, sweet odor
pH: Not available
Melting Point: -18°C
Boiling Point: 213–215°C
Flash Point: 133°C (closed cup)
Evaporation Rate: Low (not readily volatile under ambient conditions)
Vapor Pressure: 0.05 mmHg at 25°C
Solubility in Water: Miscible
Density: 1.303 g/cm³ at 20°C
Partition Coefficient (log P): -1.1
Viscosity: 25 mPa·s at 20°C
Chemical Stability: Stable under normal temperature and recommended storage conditions
Reactivity: Reacts with strong oxidizing agents, acids, alkalis; hydrolysis occurs slowly in aqueous solution
Hazardous Decomposition Products: Releases hydrogen chloride, phosgene, carbon oxides under fire, thermal stress or contact with acids
Conditions to Avoid: Excessive heat, sparks, flames, static discharge, incompatible materials
Polymerization: Not known to polymerize under standard handling
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: LD50 (oral, rat) 152 mg/kg – highly hazardous by ingestion
Chronic Effects: Evidence points to carcinogenicity in animal studies, linked to kidney, liver and testicular tumors after prolonged exposure
Irritation: Causes skin and eye irritation, respiratory tract irritation if inhaled
Mutagenicity: Suspected mutagen based on available data
Other Effects: May interfere with reproductive health, can cause CNS depression after significant exposure
Aquatic Toxicity: Toxic to aquatic organisms, risk of long-term adverse effects in aquatic environment
Degradability: Biodegrades slowly under standard environmental conditions, persistence expected if released
Bioaccumulation: Low bioaccumulative potential due to high water solubility and low partition coefficient
Mobility: High mobility in soil and water, risk of contaminating groundwater
Ecotoxicity Data: EC50 (Daphnia magna, 48 hr): 90 mg/L, LC50 (fish, 96 hr): 86 mg/L, chronic toxicity likely at sustained low-level releases
Methods: Dispose through licensed hazardous waste contractor, incinerate only in approved facilities
Do Not: Discharge to drains, surface waters or soil
Contaminated Packaging: Treat empty containers as hazardous, triple rinse and submit for chemical waste management
Regulation Reference: Follow all local, federal, national and international environment and waste legislation
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains S-3-chloro-1,2-propanediol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels: Toxic
Special Instructions: Avoid temperature extremes during transit, keep sealed, transport with compatible substances only
Marine Pollutant: Not classified as marine pollutant but precautions recommended for aquatic protection
TSCA: Listed under US Toxic Substances Control Act
REACH: Registration required for use in European Union
SARA Title III: Subject to reporting for toxic chemicals
OSHA: Classified as hazardous under OSHA regulations
IARC Classification: Group 2B (possibly carcinogenic to humans)
Other Regulations: Subject to chemical-specific workplace, transportation and consumer chemical handling laws in each jurisdiction; consult national inventories for registration status
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