Product Name: (S)-(-)-3-(tert-butylamino)-1,2-propanediol
Synonyms: (S)-(-)-Propranolol Intermediate, (S)-(-)-3-(tert-Butylamino)-1,2-propanediol
CAS Number: 34804-48-3
Recommended Use: Intermediate for pharmaceutical and chemical synthesis
Manufacturer Contact: Emergency and technical support: Quality Chemicals Inc., Emergency phone: +1-800-555-9911
GHS Classification: Acute toxicity (oral, dermal), Skin/eye irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin and eye irritation. May cause respiratory tract irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with skin and eyes. Wear protective gloves and eye protection. If inhaled, move to fresh air.
Emergency Overview: White crystalline powder, mild amine odor, irritating to mucous membranes.
Chemical Name: (S)-(-)-3-(tert-butylamino)-1,2-propanediol
CAS Number: 34804-48-3
Percent Composition: >98% by weight
Impurities: Trace related amino alcohols (<1.0%) and solvent residues (ethanol, water, <0.2%)
Molecular Formula: C7H17NO2
Molecular Weight: 147.22 g/mol
Inhalation: Remove person to fresh air, support breathing, consult medical attention if symptoms persist.
Skin Contact: Wash affected area immediately with soap and plenty of water, remove contaminated clothing, medical attention in case of persistent redness, irritation or burns.
Eye Contact: Rinse with flowing water for at least 15 minutes, keep eyelid open, remove contact lenses if safe, seek medical help if irritation or blurring continues.
Ingestion: Rinse mouth, do not induce vomiting unless told by medical professional, seek prompt consultation.
Acute Symptoms: Irritation, burn, throat discomfort, nausea, coughing, watery eyes.
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, water fog
Unsuitable Extinguishing Media: Strong water jets (may spread burning material)
Specific Hazards: Produces hazardous gases such as carbon monoxide, nitrogen oxides during combustion
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Procedures: Move containers from fire zone if possible, use water spray to cool surfaces exposed to fire
Explosion Hazards: May form explosive dust-air mixtures at high concentrations
Additional Advice: Toxic fumes probable, avoid inhaling smoke, control run-off water.
Personal Precautions: Use appropriate breathing protection, chemical-resistant gloves, avoid dust creation
Environmental Precautions: Prevent uncontrolled product from entering drains or waterways, notify relevant authority if significant contamination occurs
Clean-up Methods: Vacuum or sweep up material, use approved explosion-proof equipment, place residue in airtight containers for disposal
Spill Reporting: Record extent and response steps taken, consult with HSE or EH&S department
Decontamination: Wash area with soap and plenty of water after removal of bulk material, ventilate closed spaces.
Handling: Prevent dust formation, handle in fume hood or well-ventilated workspace, keep away from open flames and hot surfaces
Hygiene: Avoid eating, drinking, or smoking while working with chemical, wash hands after handling
Storage Conditions: Store in cool, dry location, tightly closed container, segregate from strong oxidizers and acids
Storage Temperature: Ambient temperature between 15°C and 30°C is ideal
Incompatibilities: Mineral acids, oxidizing agents, halogenated solvents
Packaging Materials: Use chemically resistant, leak-proof containers, label clearly.
Occupational Exposure Limits: No ACGIH or OSHA exposure limits established for this compound; observe standard chemical precautions
Engineering Controls: Use local exhaust ventilation, maintain air concentration below nuisance dust levels (10 mg/m3)
Personal Protection Equipment: Chemical-resistant gloves (nitrile or rubber), splash-proof safety goggles, lab coat, if dust forms then NIOSH-approved respirator
Work Practices: Keep work area free from contamination, handle with care to prevent spills, regular medical surveillance for those with repeated exposure
Environmental Controls: Use containment for waste processes, maintain safety showers and eyewash stations nearby.
Appearance: White crystalline or granular solid
Odor: Slight amine-like smell
pH (1% Solution): About 10
Melting Point: 58–62°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, methanol, ethanol, slightly soluble in ether and chloroform
Vapor Pressure: Not detectable at room temperature
Density: Approximately 1.01 g/cm3 at 25°C
Flash Point: Not determined, expected to be above 150°C
Partition Coefficient (log Kow): -0.2 (estimated)
Viscosity: Not applicable
Auto-ignition Temperature: Data not available.
Chemical Stability: Stable under normal conditions of handling and storage
Reactivity: Not reactive under standard lab conditions
Conditions to Avoid: High humidity, elevated temperatures, sources of ignition
Incompatible Materials: Strong acids, oxidizing agents, halogens
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, amines upon thermal breakdown
Hazardous Polymerization: Does not occur under foreseeable conditions.
Routes of Exposure: Ingestion, inhalation, skin/eye contact
Acute Toxicity: Oral LD50 (rat) estimated: 300–1200 mg/kg
Chronic Toxicity: No long-term effects reported in available studies
Skin Irritation: May cause moderate to severe irritation
Eye Contact: Causes stinging and watering, possible reversible injury
Inhalation: Dust exposure may affect respiratory tract, causing coughing or discomfort
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Teratogenicity/Mutagenicity: No data available; use caution, especially with pregnant women
Sensitization: No cases found but avoid repeated skin contact.
Ecotoxicity: No acute aquatic toxicity data available, structurally similar compounds show moderate toxicity to algae and invertebrates
Persistence/Degradability: Readily biodegradable in water and soil under aerobic conditions
Bioaccumulation Potential: Low, based on log Kow and molecular structure
Mobility in Soil: Expected to be relatively mobile, does not bind strongly to soils or sediments
Other Environmental Hazards: No known significant effects, but keep out of groundwater and surface water
Avoid Release: Industrial users required to contain and treat effluent, observe best practice for chemical wastewater handling.
Disposal Methods: Dispose through licensed hazardous waste company, comply with local, regional, and national regulations
Waste Code: Set by local authorities for laboratory organic chemicals
Product Disposal: Incineration in certified facility preferred, avoid landfill or direct drainage
Container Disposal: Triple-rinse and dispose as hazardous waste, do not reuse empty containers without decontamination
Precautions: Record disposal process and volume, document all hazardous material handling.
UN Number: Not regulated as hazardous for transport under UN, DOT, IATA, IMDG rules
Proper Shipping Name: Chemical, N.O.S. (not otherwise specified) for air / ground
Hazard Class: Not classified
Packing Group: Not classified
Transport Precautions: Protect from physical damage, moisture, heat during shipment; package securely
Special Transport Notes: Keep paperwork and labelling up to date; carriers must be notified of the chemical identity on MSDS.
Global Inventory Status: Listed on TSCA, REACH preregistered, included on Canada DSL
OSHA Hazard Communication: Meets criteria for hazardous material
Hazard Ratings: NFPA: Health 2, Flammability 1, Reactivity 0
SARA Title III, Section 313: Not subject
California Prop 65: Not listed
EU Classification: Irritant (Xi); Risk phrases: R22, R36/37/38; Safety phrases: S26, S37
WHMIS Classification: D2B Toxic Material Causing Other Toxic Effects
Local Restrictions: Users must check relevant national, municipal and workplace exposure and use guidelines to ensure compliance.
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