Product Name: (S)-(-)-1-Phenyl-3-chloro-1-propanol
Synonyms: (S)-3-Chloro-1-phenyl-1-propanol
Recommended Use: Laboratory chemicals, synthesis and research applications.
Manufacturer: Chemical supplier or laboratory distributor
Contact Information: Emergency phone number, business phone, address available from supplier
CAS Number: 123238-80-4
EC Number: 619-777-2
Classification: Irritant to eyes and skin; potential for respiratory irritation.
GHS Label Elements: Exclamation mark symbol, Signal Word: Warning.
Hazard Statements: Causes skin and eye irritation, may cause respiratory tract irritation, could lead to allergic reactions after repeated exposure.
Precautionary Statements: Avoid all contact with eyes, skin, or clothing. Do not breathe dust, vapor, or spray. Take care handling material near ignition sources.
Emergency Overview: White to off-white crystalline solid, faint aromatic odor, low volatility.
Potential Health Effects: Direct exposure may cause redness or swelling. If inhaled or ingested, could cause nausea, headache, dizziness. Chemical is not classified as carcinogenic or mutagenic under standard guidelines.
Chemical Name: (S)-(-)-1-Phenyl-3-chloro-1-propanol
Synonyms: (S)-3-Chloro-1-phenyl-1-propanol
CAS Number: 123238-80-4
Content/Concentration: 98% or greater, typical for research grade.
Impurities: Not routinely present above 2%, no expected hazardous side-products when handled under standard lab practices.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical attention if irritation persists.
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing and wash before reuse, see medical aid for persistent irritation.
Inhalation: Remove individual to fresh air, keep at rest, seek medical support if symptoms appear.
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, seek medical help if discomfort or symptoms develop.
Advice for First Responders: Avoid direct contact, use protective gloves and eyewear, provide treatment based on symptoms.
Extinguishing Media: Alcohol-resistant foam, dry chemical powder, or carbon dioxide are suitable; water spray only for cooling.
Specific Hazards: Combustion may produce toxic fumes of hydrogen chloride and phenyl derivatives. Possibility of hazardous decomposition at high temperature.
Protective Equipment for Firefighters: Full protective clothing including self-contained breathing apparatus recommended.
Advice: Remove containers from fire area if safe, cool nearby containers with water spray to prevent pressure buildup.
Personal Precautions: Use standard laboratory protective gear—chemical-resistant gloves, apron, goggles, avoid dust formation.
Environmental Precautions: Prevent further leakage if safe, do not allow chemical to enter drains or watercourses.
Cleanup Methods: Sweep up material and place in a clearly labelled, suitable container for disposal, ventilate area and wash spill site after cleanup completed.
Emergency Procedures: Restrict entry to spill area, evacuate unnecessary personnel.
Safe Handling Advice: Handle in a chemical fume hood, wear protective lab clothing, keep container tightly closed, avoid breathing dust or vapor.
Hygiene Measures: Do not eat, drink or smoke in work area, wash hands thoroughly after handling.
Storage Conditions: Store in a cool, dry, well-ventilated place away from strong acids, bases, and oxidizers. Keep away from open flame or heat sources.
Packaging Materials: Use glass or compatible plastic containers with secure lids, label clearly with hazard statements and date received.
Engineering Controls: Use laboratory fume hood, local exhaust ventilation, ideally with HEPA filtration.
Personal Protection for Eye/Face: Chemical splash goggles required, face shield for splash risk.
Skin Protection: Chemical-resistant gloves (Nitrile preferred), lab coat, long sleeves.
Respiratory Protection: Dust respirator or air-purifying respirator for high exposure or spill conditions.
Exposure Guidelines: No specific occupational exposure limits established, best to minimize any direct exposure.
Monitoring: Regular inspection of PPE and local ventilation systems.
Physical State: Solid, crystalline
Color: White to faintly off-white
Odor: Weak aromatic
Melting Point: 59–61 °C
Boiling Point: Decomposes before boiling
Density: ~1.25 g/cm3
Solubility in Water: Slightly soluble
Solubility (other solvents): Soluble in ethanol, DMSO, chloroform
pH Value: Not available
Vapor Pressure: Negligible at room temperature
Flash Point: Data not specifically available; handle as a combustible solid
Partition Coefficient (log Kow): Not determined
Chemical Stability: Stable under recommended storage conditions.
Reactivity: May react with strong oxidizers. Avoid acids and bases which can trigger rapid hydrolysis.
Conditions to Avoid: Prolonged exposure to heat, moisture, and direct sunlight.
Hazardous Decomposition Products: Chlorinated compounds, phenyl derivatives, carbon oxides, and hydrogen chloride under fire conditions.
Incompatible Materials: Strong oxidizing agents, strong acids, or alkali.
Polymerization: Does not readily polymerize.
Acute Toxicity: Limited animal data; low acute oral and dermal toxicity presumed based on similar structures.
Skin Contact: Irritation may result from prolonged or repeated exposure.
Eye Contact: Direct contact may cause redness, tearing, or discomfort.
Inhalation: Irritation to the respiratory tract possible, symptoms include coughing or sneezing.
Ingestion: Nausea, abdominal discomfort may occur; high doses not established for lethality in humans.
Chronic Effects: No long-term studies available; handle as potentially hazardous.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified by IARC, NTP, or OSHA based on available data.
Sensitization: Sensitization not reported, though repeated exposure can lead to dermatitis.
Ecotoxicity: No direct measurements, but predicted to be low to moderate based on structure.
Persistence and Degradability: Not expected to be rapidly biodegradable, potential concern in aquatic systems.
Bioaccumulative Potential: Bioaccumulation considered unlikely; aromatic ring may linger in sediment.
Mobility in Soil: Likely to remain at surface or slightly migrate due to low water solubility.
Other Adverse Effects: Avoid release to the environment, especially waterways and soils.
Waste Treatment Methods: Dispose through a licensed chemical waste contractor.
Product Disposal: Incineration recommended for complete destruction in accordance with local, regional, and national regulations.
Container Disposal: Rinse thoroughly, remove labels and send to chemical waste stream.
Precautions: Do not mix with solid or oxidizing waste, avoid landfill if possible.
UN Number: Not assigned due to low hazard classification.
Transport Hazard Class: Not classified as dangerous under transport regulations (ADR/RID, IMDG, IATA).
Packaging Group: Not regulated.
Environmental Hazards: Not classified as a marine pollutant.
Special Precautions: Maintain original container with legible labels, prevent breakage during transit, transport with compatible goods only.
Shipping Name: Reference chemical name, packaged as limited quantity for research transport.
United States: Not listed on TSCA inventory, laboratory use only.
Europe: Not listed in REACH Annex XVII or SVHC.
Canada: Not regulated under WHMIS, not on DSL/NDSL.
Labeling Requirements: Standard hazardous chemical labeling, hazard pictogram (exclamation mark), risk phrases for skin and respiratory irritation.
GHS Classification: Irritant category for skin/eyes.
Other National Regulations: Adhere to local, state, or country-specific safety and environmental legislation regarding laboratory chemicals.
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