Product Name: (S)-1-Chloro-2-propanol
Chemical Formula: C3H7ClO
Other Names: (S)-2-Chloro-1-propanol, Propylene chlorohydrin (S-form)
CAS Number: 127-00-4
Recommended Uses: Laboratory chemical, pharmaceutical synthesis, chemical intermediate
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GHS Classification: Acute toxicity (oral), Category 4; Eye irritation, Category 2A; Skin irritation, Category 2; Specific target organ toxicity following single exposure, Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin and serious eye irritation. May cause respiratory irritation.
Precautionary Statements: Do not eat, drink or smoke during use. Wash hands thoroughly after handling. Use only outdoors or in well-ventilated areas. Wear eye protection, protective gloves, and suitable protective clothing.
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Hazards: Vapors or mists may irritate respiratory tract. Contact may cause dermatitis. Ingestion can lead to gastrointestinal disturbance and systemic effects.
Target Organs: Eyes, skin, respiratory system, central nervous system
Chemical Identity: (S)-1-Chloro-2-propanol
Percentage by Weight: ≥ 98%
CAS Number: 127-00-4
Impurities/ Stabilizing Additives: May include water (<1%), related halogenated propanols (<1%)
EC Number: 204-816-0
Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes. Remove contact lenses if present and easy to do. Seek medical attention.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Get medical help if irritation develops or persists.
Inhalation: Move person to fresh air. Monitor breathing. If breathing is difficult, give oxygen and seek immediate medical care.
Ingestion: Rinse mouth with water. Do not induce vomiting. If person is conscious, give small amounts of water. Seek immediate medical help.
Important Symptoms/Effects: Burning sensation, cough, dizziness, headache, gastrointestinal upset possible. Delayed effects may occur.
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide or water spray for large fires.
Specific Hazards Arising from Chemical: Releases toxic gases including hydrogen chloride and carbon monoxide under fire conditions. Vapors can form explosive mixtures with air.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective equipment. Avoid inhalation of combustion products.
Special Firefighting Procedures: Use water spray to cool exposed containers. Evacuate personnel to a safe area. Prevent run-off from entering drains.
Flash Point: Approximately 75°C (closed cup, estimated)
Personal Precautions: Evacuate personnel from the area if necessary. Ventilate affected area. Avoid contact with skin, eyes, and clothing. Do not breathe vapors or mists.
Protective Equipment: Wear chemical-resistant gloves, safety goggles, protective clothing, and a suitable respirator if required.
Environmental Precautions: Prevent product from entering drains, surface water, or soil. Notify relevant authorities if release occurs.
Methods for Clean-up: Absorb spillage with inert, non-combustible material (sand, earth, vermiculite). Collect and arrange for disposal in tight, labeled containers. Wash contaminated surface with water and detergent. Ventilate area after clean-up.
Decontamination: Dispose of cleaning materials and residues in compliance with local regulations.
Safe Handling Practices: Only trained personnel should handle. Keep away from incompatible materials including strong oxidizers and bases. Avoid inhaling mists or vapors. Avoid prolonged or repeated exposure. Use proper industrial hygiene practices.
Storage Conditions: Store in tightly closed original container in a cool, dry, well-ventilated area away from heat and direct sunlight. Store away from foodstuffs and incompatible materials.
Incompatible Materials: Strong bases, strong oxidizing agents, metals, acids.
Special Handling Instructions: Open containers under local exhaust ventilation. Ensure all equipment is grounded and bonded during filling or transfer to control static discharge. Keep containers tightly sealed when not in use.
Recommended Packaging Materials: Use glass or compatible plastic containers.
Occupational Exposure Limits: Not established for this specific compound. Use workplace exposure guidelines covering similar chlorinated alcohols where available.
Engineering Controls: Work in fume hood or with adequate local exhaust ventilation. Provide emergency eyewash stations and safety showers in the immediate area.
Personal Protective Equipment: Wear nitrile or neoprene gloves, chemical safety goggles, face shield, laboratory coat or full body suit. Use a NIOSH-approved respirator if airborne concentrations exceed threshold limits or in poorly ventilated environments.
Hygiene Measures: Remove contaminated clothing and wash thoroughly before reuse. Wash hands before breaks and after handling.
Monitoring Procedures: Regular assessment of vapour concentrations and potential splashes.
Appearance: Clear, colorless to pale yellow liquid
Odor: Mild, sweet, pungent
Odor Threshold: Not available
pH: Not applicable (neutral compound)
Melting Point: -50°C to -44°C (estimated)
Boiling Point: 120-123°C
Flash Point: 75°C (closed cup, estimated)
Evaporation Rate: Not available
Flammability: Combustible
Upper/Lower Explosive Limits: Not available
Vapor Pressure: 1.1 mmHg at 25°C
Vapor Density: 2.0 (air = 1)
Relative Density: 1.16 at 20°C
Solubility in Water: Miscible
Partition Coefficient (n-octanol/water): Log Kow 0.85 (estimated)
Auto-ignition Temperature: 380°C (estimated)
Decomposition Temperature: Not available
Viscosity: Not determined
Chemical Stability: Stable under recommended storage and handling conditions.
Hazardous Reactions: May react vigorously with strong oxidizing agents and bases.
Conditions to Avoid: Excessive heat, open flame, incompatible chemical contact, poor ventilation.
Incompatible Materials: Strong bases, oxidizing agents, strong acids, metals such as zinc, aluminum.
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide under fire conditions.
Polymerization: No hazardous polymerization reported.
Likely Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity Data: Oral LD50 (rat): 1400 mg/kg (estimate based on structurally similar materials)
Skin Corrosion/Irritation: Causes irritation and potential dermatitis after prolonged exposure
Serious Eye Damage/Irritation: Causes eye irritation; potential for corneal injury
Respiratory or Skin Sensitization: Not expected to be a skin sensitizer
STOT – Single Exposure: May cause drowsiness, headache, nausea, central nervous system depression
STOT – Repeated Exposure: No chronic toxicity data available; repeated exposure can result in liver and kidney effects from metabolite accumulation in similar chlorinated propanols
Germ Cell Mutagenicity: No data
Carcinogenicity: Not listed as a carcinogen by IARC, ACGIH, NTP, OSHA
Reproductive Toxicity: No data available
Aspiration Hazard: Not classified for aspiration toxicity
Eco-toxicity: Harmful to aquatic organisms with potential for acute toxicity to fish and invertebrates
Aquatic Toxicity: LC50 (fish, 96h): 90 mg/L (estimated)
Persistence and Degradability: Expected to be biodegradable. Moderate to fast biodegradation in aerobic environments indicated in related substances.
Bioaccumulative Potential: Low bioaccumulation (estimated log Kow <1)
Mobility in Soil: High water solubility indicates likely mobility through soil to groundwater
Other Adverse Effects: Not readily identified, but careful containment helps limit exposure to the environment
Waste Disposal Methods: Dispose of material through a licensed hazardous waste disposal contractor. Comply with local, regional, or national regulations. Use chemical incineration with afterburner and scrubber for organic halides.
Container Disposal: Triple rinse containers with suitable solvent. Destroy by controlled incineration.
Sewage Disposal: Do not discharge to sewer systems or natural waters.
Precautions: Do not mix with other types of chemicals during disposal.
UN Number: 2735 (for related chlorinated alcohols, confirm regulatory listing)
Proper Shipping Name: Chlorinated alcohol, n.o.s. (consult relevant authority for specifics)
Transport Hazard Class: 8 (corrosive liquids)
Packing Group: III
Labels: Corrosive
Special Precautions for User: Do not transport with foodstuffs. Ensure containers are secure and leak-proof.
Environmental Hazards: Not a marine pollutant under standard tests, but avoid release to waterways
Transport in Bulk: Follow recommendations of International Maritime Dangerous Goods (IMDG) and UN Model Regulations.
OSHA Hazard Communication: This material classified as hazardous according to OSHA’s Hazard Communication Standard (29 CFR 1910.1200).
TSCA Status: Listed or exempt
SARA Title III: Not subject to notification requirements under SARA Sections 302, 304, and 313.
REACH Regulation: Annex II exempt only for research use; supply chain registration may be required.
California Proposition 65: Not listed
Other Regulations: Subject to workplace exposure and environmental management rules. Laboratory chemical hygiene plan must address risk for employees.
Chemical Inventory Listing: Appears on major international inventory lists including TSCA, EINECS, DSL/NDSL.
Labeling Requirements: Must bear GHS, transport, and environmental labels suited to hazard category and packing group.
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