Chemical Name: (R)-(-)-Propylene Glycol
Synonyms: (R)-(-)-1,2-Propanediol, (R)-(-)-1,2-dihydroxypropane
CAS Number: 4254-15-3
Recommended Use: Laboratory reagents, pharmaceutical intermediates, cosmetic formulations, food additive
Supplier: Manufacturer’s contact details provided on label
Emergency Phone: Emergency response number listed on product package
Molecular Formula: C3H8O2
Molecular Weight: 76.09 g/mol
GHS Classification: Not classified as hazardous
Signal Word: None required under GHS
Hazard Statements: May cause mild skin and eye irritation, ingestion may create mild gastrointestinal discomfort
Precautionary Statements: Wash hands after handling, avoid excessive contact with eyes, do not ingest in large amounts
Pictogram: None
Routes of Exposure: Skin, eyes, ingestion, inhalation of mist
General Hazards: Spills may produce slippery surfaces, vapors at elevated temperatures could irritate mucosa
NFPA Ratings: Health 1, Flammability 1, Reactivity 0
Chemical: (R)-(-)-Propylene Glycol
Concentration: ≥99%
Impurities: Trace amounts of water, related glycol isomers (<0.5%)
Additives: None
General Advice: Show this data sheet to the physician
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical attention if irritation persists
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, seek medical attention if rash or irritation develops
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical attention if symptoms continue
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, seek medical advice if large volume consumed or if symptoms appear
Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide
Unsuitable Extinguishing Media: Do not use direct water jet on burning material
Hazards from Combustion: May release carbon monoxide, carbon dioxide, and other irritating fumes
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective clothing
Special Procedures: Cool exposed containers with water spray, remove containers from hazard zone if safe to do so
Personal Precautions: Avoid eye and prolonged skin contact, ensure adequate ventilation, eliminate ignition sources, wear suitable protective gear
Environmental Precautions: Prevent entry into drains, watercourses, or soil
Spill Response: Contain spilled liquid, use inert absorbent material, collect in containers for disposal
Cleaning Methods: Wash spill area thoroughly with water and detergent after material pick-up
Handling: Use in well-ventilated areas, avoid prolonged or repeated contact with skin and eyes, wash hands thoroughly after handling, keep away from sources of ignition
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated place, protect from heat, light, and moisture, segregate from strong acids and oxidizers
Incompatibilities: Avoid storing near strong oxidizing agents, acids, and alkalis
Special Considerations: Use clean, labeled containers, prevent accidental leaks and spills by regular container inspections
Control Parameters: No established exposure limit by OSHA, ACGIH, or NIOSH
Engineering Controls: Good general ventilation adequate for normal handling, local exhaust during large-scale operations
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety glasses or goggles, lab coat or protective clothing
Respiratory Protection: Not required under normal conditions, use approved respirator if mist or aerosol is likely
Hygiene Measures: Practice routine handwashing, change contaminated clothing promptly, prevent eating or drinking near work area
Appearance: Clear, colorless, viscous liquid
Odor: Odorless or slight sweet odor
Melting Point: -59 °C
Boiling Point: 187 °C
Flash Point: 104 °C (closed cup)
Evaporation Rate: Negligible at room temperature
Flammability: Low flammability, vapors may form explosive mixture with air above flash point
Vapor Pressure: 0.017 mmHg at 20 °C
Vapor Density: 2.62 (air = 1)
Relative Density: 1.04 g/cm³ at 20 °C
Solubility: Miscible with water
Partition Coefficient: log Kow -0.92
Auto-ignition Temperature: 371 °C
Decomposition Temperature: Not established
Viscosity: 58.1 mPa·s at 25 °C
pH: Neutral (6-7 for 10% solution)
Chemical Stability: Stable under recommended storage conditions
Thermal Decomposition: Decomposes when heated to high temperatures, generating acrid smoke and irritating fumes
Conditions to Avoid: Heat, flames, spark-producing equipment, direct sunlight
Incompatible Materials: Strong acids, oxidizing agents, alkali metals, isocyanates
Hazardous Reactions: No dangerous reactions known during correct use and storage
Polymerization: Will not occur under normal processing conditions
Acute Toxicity: Oral LD50 (rat): >20,000 mg/kg, relatively low toxicity
Skin Irritation: Mildly irritating on prolonged exposure
Eye Irritation: Mild eye irritant
Respiratory Effects: Inhalation of excessive mist may irritate respiratory tract
Sensitization: Not expected to cause sensitization
Chronic Effects: No known adverse chronic health effects, not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Not mutagenic in standard laboratory tests
Reproductive Toxicity: Not known to cause reproductive effects
Ecotoxicity: Low acute toxicity to aquatic organisms, LC50 (fish) > 100 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation Potential: Low, log Kow less than zero
Mobility in Soil: High mobility, considerable water solubility
Other Adverse Effects: Not expected to pose significant risk to environment in small spills, excessive large-scale release can deplete oxygen in water bodies due to rapid microbial degradation
Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations
Preferred Disposal: Send to licensed chemical disposal facility, incineration or distillation recovery preferred wherever possible
Packaging: Rinse empty containers thoroughly, dispose of in compliance with regulatory guidelines, prevent accidental spillage during transport to disposal sites
Recycle/Reuse: Reuse or recycle content if suitable equipment and process available
UN Number: Not regulated
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Prevent leaks and spills during handling, transport in secure, upright containers
Transport in Bulk: Follow requirements under Annex II of MARPOL 73/78 and IBC Code for bulk transport
US TSCA Inventory: Listed
EC Inventory (EINECS/ELINCS): Listed
REACH Regulation: Registered
SARA Title III: Not listed
California Proposition 65: Not listed
WHMIS Classification: Not controlled
Other International Regulations: Meets requirements for use in foods (subject to purity), cosmetics, pharmaceutical intermediates according to country-specific legislation
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