Product Name: (R)-(-)-Norepinephrine L-Bitartrate Monohydrate
CAS Number: 108341-18-0
Synonyms: (-)-Norepinephrinum, Levonor, Arterenol, Levarterenol bitartrate monohydrate
Use: Pharmaceutical active ingredient, research chemical
Supplier: Information typically provided on label or accompanying documentation
Contact Number: Provided by distributing company
Emergency Phone: Refer to supplier documentation
GHS Classification: Not classified as hazardous by GHS criteria for pure substance but may present risks upon contact
Main Hazards: May cause irritation to skin, eyes, respiratory tract. Overexposure through inhalation, ingestion, or injection can trigger serious cardiovascular and neuropsychological effects.
Hazard Symbols: None mandated under GHS; recommend caution
Precautionary Statements: Avoid exposure through inhalation, ingestion, or skin/eye contact. Wear appropriate protection when handling.
Labeling: Pharmaceutical use labeling requirements apply, as per local regulations.
Chemical Name: (R)-(-)-Norepinephrine L-Bitartrate Monohydrate
Molecular Formula: C8H11NO3·C4H6O6·H2O
Percentage: ≥99% pure
Impurities: Not more than 1%, primarily minor organic or inorganic residues from synthesis
Active Components: (R)-(-)-Norepinephrine (base)
Inert Materials: None known at this purity grade
Other Chemicals: Bitartrate and water of crystallization, providing molecular stability
Inhalation: Move to fresh air. Seek medical attention if symptoms like shortness of breath, dizziness, or chest pain present.
Skin Contact: Remove contaminated clothing. Rinse affected area with soap and water. Seek medical advice if irritation develops.
Eye Contact: Rinse gently with water for 15 minutes. Hold eyelids open and seek immediate medical care if irritation or pain persists.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical attention due to possible cardiovascular effects.
Advice for Rescuers: Avoid contact with substance during aid. Use gloves and mask.
Suitable Extinguishing Media: Use water spray, dry chemical, CO2, or foam. Avoid direct water jet.
Unusual Fire Hazards: Combustion releases toxic fumes, including nitrogen oxides and carbon oxides.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full gear.
Special Precautions: Prevent runoff from entering drains. Evacuate if smoke is produced.
Thermal Hazards: Container rupture possible under heat.
Personal Precautions: Wear gloves, goggles, lab coat, N95 mask if dust is airborne.
Environmental Measures: Prevent further leakage or spillage if safe; avoid discharge into drains, surface/groundwater.
Containment & Cleanup: Sweep or scoop spillage in a manner that minimizes dust generation. Place in a suitable, closed container for disposal. Decontaminate area fully.
Disposal: Treat collected material as hazardous chemical waste.
Handling: Use in well-ventilated area inside a chemical fume hood. Avoid inhalation, ingestion, and contact with skin or eyes. Practice good lab hygiene.
Storage: Keep container tightly closed at 2-8° C. Store in original packaging, shielded from moisture and light. Avoid incompatible materials like strong oxidizers and acids.
Storage Class: According to local chemical safety storage class for pharmaceuticals or hazardous chemicals.
Incompatibles: Strong acids, oxidizing agents; can cause decomposition or hazardous reactions.
Recommended Shelf Life: Check expiration on label, monitor for changes in color, texture, or smell.
Engineering Controls: Use chemical hood with efficient ventilation and filtration.
Exposure Limits: No occupational exposure limits established for this compound.
Personal Protective Equipment: Nitrile or latex gloves, protective laboratory coat, safety goggles, fitted N95 or higher mask if powder dust present.
Hygiene Measures: Wash hands after handling, avoid eating/drinking/smoking near laboratory work.
Respiratory Protection: Use protection if airborne dust or vapors may be encountered.
Appearance: White or slightly off-white crystalline powder
Odor: Odorless or very faint
pH: 3.0-4.5 (10% solution in water)
Melting Point: >200 °C (decomposition observed)
Solubility: Freely soluble in water, slightly soluble in ethanol
Molecular Weight: Approx. 337.3 g/mol (hydrate)
Vapor Pressure: Not applicable for solid
Partition Coefficient: Not available; expected to be low due to high water solubility
Boiling Point: Not defined
Other Properties: Stable solid, hygroscopic, non-volatile
Chemical Stability: Stable under recommended storage and handling conditions.
Hazardous Decomposition: May release carbon oxides, nitrogen oxides upon decomposition or burning.
Reactive With: Strong acids, bases, and oxidizing agents.
Conditions to Avoid: Excessive heat, sunlight, moisture, incompatible materials.
Polymerization: Not expected to occur.
Acute Toxicity: Low acute toxicity by oral, dermal, or inhalation exposure based on available data for bitartrate salts. Large exposures can cause severe cardiovascular and CNS effects—tachycardia, hypertension, anxiety, convulsions.
Chronic Effects: Not studied in long-term settings; repeated exposure could stress cardiovascular system.
Skin/Eye Irritation: May cause mild, reversible irritation.
Sensitization: Not known to cause allergic reactions in laboratory studies but hypersensitivity possible.
Carcinogenicity: No data suggesting carcinogenic effects.
Mutagenicity: No published data.
Reproductive Toxicity: Data limited; administer to pregnant individuals only if clearly needed.
Target Organs: Central nervous system, cardiovascular system.
Ecotoxicity: No comprehensive ecotoxicological data; expected to be of low environmental hazard due to dilution and degradation in wastewater systems.
Mobility: Expected to be highly mobile in water.
Persistence and Degradability: Predicted to degrade steadily in environment.
Bioaccumulation: Low potential for accumulation in organisms due to high solubility in water.
Other Adverse Effects: No known long-term or cumulative environmental impacts.
Aquatic Toxicity: No specific data, prudent to avoid release.
Waste Disposal Methods: Dispose of as hazardous pharmaceutical waste in accordance with local, regional, national, and federal regulations.
Container Disposal: Triple rinse empty containers before disposal, destroy to prevent reuse.
Sewage Disposal: Do not release into sewers or natural waterways.
Recommended Disposal Site: Incineration under controlled conditions by licensed chemical waste handler.
UN Number: Not regulated for transport under UN Recommendations
Transport Hazard Class: Not classified as hazardous for transport
Packing Group: None assigned
Proper Shipping Name: Not regulated/
Special Precautions: Ship in original sealed container. Minimize breakage risk, guard from spills.
Labeling: Clearly label as research chemical or pharmaceutical, as required by the receiving country.
Additional Information: Protect from physical damage and extreme temperatures in transit.
US Regulations: Not listed as a controlled substance. Occupational use subject to OSHA, EPA standards for laboratory chemicals; FDA regulated for pharmaceutical use.
EU Regulations: Not covered as hazardous under CLP Regulation; subject to REACH compliance for chemical samples/imports.
Other Local Regulations: May be covered by country-specific pharmaceutical or precursor controls, especially as a sympathomimetic amine.
Inventory Listings: May appear in registries (e.g., TSCA, EINECS, DSL) as permitted substance.
Labeling Requirements: Follow local labeling for research chemicals, pharmaceuticals, or hazardous materials depending on use case.
Workplace Controls: Follow safety data and local risk assessment for handling procedures and incident reporting.
Providing high-quality chemical products and logistics solutions for global trade partners.
